Q6P2Q9
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
NCBI Official Synonym Full Names
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
NCBI Protein Information
pre-mRNA-processing-splicing factor 8; p220; PRP8 homolog; OTTHUMP00000115657; splicing factor Prp8; apoptosis-regulated protein 1; apoptosis-regulated protein 2; 220 kDa U5 snRNP-specific protein; precursor mRNA processing protein; U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p
UniProt Protein Name
Pre-mRNA-processing-splicing factor 8
UniProt Synonym Protein Names
220 kDa U5 snRNP-specific protein; PRP8 homolog; Splicing factor Prp8; p220
UniProt Synonym Gene Names
UniProt Entry Name
PRP8_HUMAN
NCBI Summary for PRPF8
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq]
UniProt Comments for PRPF8
PRPF8: Central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. Interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes. Defects in PRPF8 are the cause of retinitis pigmentosa type 13 (RP13). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP13 inheritance is autosomal dominant.
Protein type: Spliceosome; RNA-binding; RNA splicing
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: nucleoplasm; membrane; snRNP U5; nuclear speck; nucleus
Molecular Function: U5 snRNA binding; protein binding; U6 snRNA binding
Biological Process: RNA splicing, via transesterification reactions; nuclear mRNA splicing, via spliceosome; assembly of spliceosomal tri-snRNP; RNA splicing; gene expression; mRNA processing
Disease: Retinitis Pigmentosa 13
Research Articles on PRPF8
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-PRPF8 antibody
Pathways associated with anti-PRPF8 antibody
Diseases associated with anti-PRPF8 antibody
Organs/Tissues associated with anti-PRPF8 antibody
|