NP_001639.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,116 Da
NCBI Official Full Name
prostate-specific antigen isoform 1 preproprotein
NCBI Official Synonym Full Names
kallikrein-related peptidase 3
NCBI Protein Information
prostate-specific antigen
UniProt Protein Name
Prostate-specific antigen
UniProt Synonym Protein Names
Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase
UniProt Synonym Gene Names
UniProt Entry Name
KLK3_HUMAN
NCBI Summary for PSA
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for PSA
PSA: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Forms heterodimer with SERPINA5. Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Belongs to the peptidase S1 family. Kallikrein subfamily.
Protein type: EC 3.4.21.77; Protease; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 19q13.41
Cellular Component: extracellular region; nucleus
Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity
Biological Process: negative regulation of angiogenesis; cellular protein metabolic process; proteolysis
Product References and Citations for anti-PSA antibody
Novel electrical detection of label-free disease marker proteins using piezoresistive self-sensing micro-cantilevers; Kyung Wook Weea, Ghi Yuun Kanga, Jaebum Parka, Ji Yoon Kanga, Dae Sung Yoona, Jung Ho Parkb, Tae Song Kim (Biosensors and Bioelectronics: Volume: 20 Issue: 10 Page: 1932-1938 DOI: 10.1016/j.bios.2004.09.023)
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Products associated with anti-PSA antibody
Pathways associated with anti-PSA antibody
Diseases associated with anti-PSA antibody
Organs/Tissues associated with anti-PSA antibody
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