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anti-PSAP antibody :: Mouse anti-Human PSAP Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS370103
Unit / Price
5 Control Slides  /  $130 +1 FREE 8GB USB
0.1 mL (Concentrate)  /  $160 +1 FREE 8GB USB
3 ml (Prediluted)  /  $165 +1 FREE 8GB USB
7 ml (Prediluted)  /  $205 +1 FREE 8GB USB
0.5 mL (Concentrate)  /  $230 +1 FREE 8GB USB
15 ml (Prediluted)  /  $310 +1 FREE 8GB USB
1 mL (Concentrate)  /  $345 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PSAP, Monoclonal Antibody

 Also Known As   


 Product Gene Name   

anti-PSAP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (73576055..73611082, complement). Location: 10q21-q22
 OMIM    176801
 3D Structure    ModBase 3D Structure for P07602
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    PASE/4LJ
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    PSAP is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
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 Control    Prostate
 Localization    Cytoplasmic
 Reactivity Note    Paraffin, Frozen
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 Preparation and Storage    Store at 2 to 8 degree C in the dark.
 Other Notes    Small volumes of anti-PSAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PSAP antibody

   Prostatic specific acid phosphatase (PSAP) is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases. The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, (such as Sickle-Cell Disease), Multiple Myeloma or Lysosomal Storage Diseases, (such as Gaucher's disease), will show moderately increased levels. Certain medications can cause temporary increases or decreases in acid phosphatase levels. Manipulation of the prostate gland through massage, biopsy or rectal exam before a test may increase the levels of PSAP. This antibody reacts with prostatic specific acid phosphatase in the glandular epithelium of the normal and Hyperplastic Prostate, Carcinoma of the prostate and metastatic cells of Prostatic Carcinoma. This marker may be helpful in pinpointing the site of origin in cases of Metastatic Carcinoma of the prostate, and is considered a more sensitive marker than PSA. However, it also offers less specificity.
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 Dilution Information of anti-PSAP antibody    anti-PSAP antibody Dilution Information image
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 Immunohistochemistry (IHC) of anti-PSAP antibody    anti-PSAP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PSAP. It may not necessarily be applicable to this product.
 NCBI GI #    48145609
 NCBI GeneID    5660
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 UniProt Primary Accession #    P07602 [Other Products]
 UniProt Secondary Accession #    P07292; P15793; P78538; P78541; P78546; P78547; P78558; Q6IBQ6; Q92739; Q92740; Q92741 [Other Products]
 UniProt Related Accession #    O75905; P07602; Q53FJ5; Q59EN5; Q5BJH1 [Other Products]
 Molecular Weight    58,113 Da
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 NCBI Official Full Name    PSAP
 NCBI Official Synonym Full Names    prosaposin
 NCBI Official Symbol    PSAP [Similar Products]
 NCBI Official Synonym Symbols   
GLBA; SAP1; FLJ00245; MGC110993
[Similar Products]
 NCBI Protein Information    proactivator polypeptide; OTTHUMP00000019776; OTTHUMP00000019777; sphingolipid activator protein-1
 UniProt Protein Name    Proactivator polypeptide
 UniProt Synonym Protein Names   
Protein ASaposin-B-ValSaposin-B; Alternative name(s):; Cerebroside sulfate activator; CSAct; Dispersin; Sphingolipid activator protein 1; SAP-1; Sulfatide/GM1 activatorSaposin-C; Alternative name(s):; A1 activator; Co-beta-glucosidase; Glucosylceramidase activator; Sphingolipid activator protein 2; SAP-2Saposin-D; Alternative name(s):; Component C; Protein C
 Protein Family    Prosaposin
 UniProt Gene Name    PSAP [Similar Products]
 UniProt Synonym Gene Names    GLBA; SAP1 [Similar Products]
 UniProt Entry Name    SAP_HUMAN
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 NCBI Summary for PSAP    This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
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 UniProt Comments for PSAP    Function: The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymic proteins: the sphingolipids activator proteins (coproteins).Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC and galactosylceramide by beta-galactosylceramidase (EC Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC, GM1 gangliosides by beta-galactosidase (EC and globotriaosylceramide by alpha-galactosidase A (EC Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC

Subunit structure: Saposin-B is a homodimer.

Subcellular location: Lysosome.

Post-translational modification: This precursor is proteolytically processed to 4 small peptides, which are similar to each other and are sphingolipid hydrolase activator proteins.N-linked glycans show a high degree of microheterogeneity.The one residue extended Saposin-B-Val is only found in 5% of the chains.

Involvement in disease: Defects in PSAP are the cause of combined saposin deficiency (CSAPD) [

MIM:611721]; also known as prosaposin deficiency. CSAPD is due to absence of all saposins, leading to a fatal storage disorder with hepatosplenomegaly and severe neurological involvement. Ref.31 Ref.35Defects in PSAP saposin-B region are the cause of leukodystrophy metachromatic due to saposin-B deficiency (MLD-SAPB) [

MIM:249900]. MLD-SAPB is an atypical form of metachromatic leukodystrophy. It is characterized by tissue accumulation of cerebroside-3-sulfate, demyelination, periventricular white matter abnormalities, peripheral neuropathy. Additional neurological features include dysarthria, ataxic gait, psychomotr regression, seizures, cognitive decline and spastic quadriparesis.Defects in PSAP saposin-C region are the cause of atypical Gaucher disease (AGD) [

MIM:610539]. Affected individuals have marked glucosylceramide accumulation in the spleen without having a deficiency of glucosylceramide-beta glucosidase characteristic of classic Gaucher disease, a lysosomal storage disorder. Ref.32 Ref.37Defects in PSAP saposin-A region are the cause of atypical Krabbe disease (AKRD) [

MIM:611722]. AKRD is a disorder of galactosylceramide metabolism. AKRD features include progressive encephalopathy and abnormal myelination in the cerebral white matter resembling Krabbe disease. Ref.36Note=Defects in PSAP saposin-D region are found in a variant of Tay-Sachs disease (GM2-gangliosidosis).

Miscellaneous: Saposin-B co-purifies with 1 molecule of phosphatidylethanolamine.

Sequence similarities: Contains 2 saposin A-type domains.Contains 4 saposin B-type domains.
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 Research Articles on PSAP    1. saposin C caused stimulation of androgen receptor expression and activity by associations with Src kinases
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PSAP antibodyPathways associated with anti-PSAP antibody
 Reference Product  PubMed Publications
 GBA antibody  >2 publications with PSAP and GBA
 CTSD antibody  >2 publications with PSAP and CTSD
 CD1B antibody  >1 publications with PSAP and CD1B
 Products by Pathway  Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Platelet Activation Pathway antibodies  Platelet Activation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
Diseases associated with anti-PSAP antibodyOrgans/Tissues associated with anti-PSAP antibody
 Disease Name  Pubmed Publications
 Lipidoses Antibodies  >84 publications with PSAP and Lipidoses
 Neoplasms Antibodies  >78 publications with PSAP and Neoplasms
 Prostatic Neoplasms Antibodies  >57 publications with PSAP and Prostatic Neoplasms
 Carcinoma Antibodies  >55 publications with PSAP and Carcinoma
 Adenocarcinoma Antibodies  >40 publications with PSAP and Adenocarcinoma
 Demyelinating Diseases Antibodies  >27 publications with PSAP and Demyelinating Diseases
 Death Antibodies  >27 publications with PSAP and Death
 Skin Diseases Antibodies  >19 publications with PSAP and Skin Diseases
 Liver Diseases Antibodies  >18 publications with PSAP and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >89 publications with PSAP and Brain
 Prostate Antibodies  >73 publications with PSAP and Prostate
 Blood Antibodies  >54 publications with PSAP and Blood
 Liver Antibodies  >46 publications with PSAP and Liver
 Nerve Antibodies  >43 publications with PSAP and Nerve
 Testis Antibodies  >41 publications with PSAP and Testis
 Kidney Antibodies  >36 publications with PSAP and Kidney
 Skin Antibodies  >31 publications with PSAP and Skin
 Spleen Antibodies  >24 publications with PSAP and Spleen
 Muscle Antibodies  >17 publications with PSAP and Muscle
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