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anti-PTH1R antibody :: Mouse anti-Human PTH1R Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850104
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PTH1R, Monoclonal Antibody

 Also Known As   

PTH1R Antibody

 Product Synonym Names    PFE; PTHR; PTHR1; MGC138426; MGC138452; PTH1R
 Product Gene Name   

anti-PTH1R antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600002
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 Clonality    Monoclonal
 Clone Number    4D2
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Purified recombinant fragment of human PTH1R expressed in E. Coli.
 Species    Mouse IgG1
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at -20 degree C.
 Other Notes    Small volumes of anti-PTH1R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PTH1R antibody

   Background: The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene.
 Product Categories/Family for anti-PTH1R antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-PTH1R antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-PTH1R antibody    WB: 1/500 - 1/2000, IHC: 1/200-1/1000, IF: 1/200-1/1000, ELISA: Propose dilution 1/10000
Not yet tested in other applications.
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 Testing Data of anti-PTH1R antibody    Figure 1: Western blot analysis using PTH1R mAb against PTH1R-hIgGFc transfected HEK293 cell lysate.
anti-PTH1R antibody Testing Data image
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 Testing Data #2 of anti-PTH1R antibody    Figure 2: Immunohistochemical analysis of paraffin-embedded human kidney tissues using PTH1R mouse mAb with DAB staining.
anti-PTH1R antibody Testing Data #2 image
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 Testing Data #3 of anti-PTH1R antibody    Figure 3: Immunofluorescence analysis of SK-BR-3 cells using PTH1R mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
anti-PTH1R antibody Testing Data #3 image
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NCBI/Uniprot data below describe general gene information for PTH1R. It may not necessarily be applicable to this product.
 NCBI GI #    4506271
 NCBI GeneID    5745
 NCBI Accession #    NP_000307.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000316.2 [Other Products]
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 UniProt Secondary Accession #    Q2M1U3 [Other Products]
 UniProt Related Accession #    Q03431 [Other Products]
 Molecular Weight    66kDa
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 NCBI Official Full Name    parathyroid hormone/parathyroid hormone-related peptide receptor
 NCBI Official Synonym Full Names    parathyroid hormone 1 receptor
 NCBI Official Symbol    PTH1R [Similar Products]
 NCBI Official Synonym Symbols   
PFE; PTHR; PTHR1
[Similar Products]
 NCBI Protein Information    parathyroid hormone/parathyroid hormone-related peptide receptor; PTH1 receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor; parathyroid hormone receptor 1; seven transmembrane helix receptor; parathyroid hormone/parathyroid hormone-related protein receptor
 UniProt Protein Name    Parathyroid hormone/parathyroid hormone-related peptide receptor
 UniProt Synonym Protein Names   
PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor
 Protein Family    Parathyroid hormone/parathyroid hormone-related peptide receptor
 UniProt Gene Name    PTH1R [Similar Products]
 UniProt Synonym Gene Names    PTHR; PTHR1; PTH/PTHr receptor; PTH1 receptor [Similar Products]
 UniProt Entry Name    PTH1R_HUMAN
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 NCBI Summary for PTH1R    The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
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 UniProt Comments for PTH1R    PTHR: This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC). JMC is a rare autosomal dominant disorder characterized by a short-limbed dwarfism associated with hypercalcemia and normal or low serum concentrations of the two parathyroid hormones. Defects in PTH1R are the cause of chondrodysplasia Blomstrand type (BOCD). BOCD is a severe skeletal dysplasia. Defects in PTH1R may be a cause of enchondromatosis multiple (ENCHOM). Enchondromas are common benign cartilage tumors of bone. They can occur as solitary lesions or as multiple lesions in enchondromatosis (Ollier and Maffucci diseases). Clinical problems caused by enchondromas include skeletal deformity and the potential for malignant change to osteosarcoma. Defects in PTH1R are the cause of Eiken skeletal dysplasia (EISD); also known as bone modeling defect of hands and feet. It is a rare familial autosomal recessive skeletal dysplasia. It is characterized by multiple epiphyseal dysplasia, with extremely retarded ossification, principally of the epiphyses, pelvis, hands and feet, as well as by abnormal modeling of the bones in hands and feet, abnormal persistence of cartilage in the pelvis and mild growth retardation. Defects in PTH1R are a cause of primary failure of tooth eruption (PFE). PFE is a rare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption. Belongs to the G-protein coupled receptor 2 family.

Protein type: Membrane protein, integral; GPCR, family 2; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p22-p21.1

Cellular Component: integral to plasma membrane; brush border membrane; basolateral plasma membrane; cytoplasm; apical plasma membrane; plasma membrane; nucleus; receptor complex

Molecular Function: protein binding; protein self-association; peptide hormone binding; parathyroid hormone receptor activity

Biological Process: cell maturation; G-protein signaling, adenylate cyclase activating pathway; bone mineralization; osteoblast development; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cell proliferation; elevation of cytosolic calcium ion concentration; positive regulation of cell proliferation; chondrocyte differentiation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); skeletal development; bone resorption; aging

Disease: Eiken Syndrome; Chondrodysplasia, Blomstrand Type; Failure Of Tooth Eruption, Primary; Metaphyseal Chondrodysplasia, Jansen Type
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 Research Articles on PTH1R    1. It is a critical physiological regulator of various biological processes, including bone and cartilage metabolism. (review)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PTH1R antibodyOrgans/Tissues associated with anti-PTH1R antibody
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >165 publications with PTH1R and Bone
 Kidney Antibodies  >50 publications with PTH1R and Kidney
 Connective Tissue Antibodies  >37 publications with PTH1R and Connective Tissue
 Muscle Antibodies  >21 publications with PTH1R and Muscle
 Embryonic Tissue Antibodies  >9 publications with PTH1R and Embryonic Tissue
 Heart Antibodies  >8 publications with PTH1R and Heart
 Brain Antibodies  >8 publications with PTH1R and Brain
 Nerve Antibodies  >6 publications with PTH1R and Nerve
 Lung Antibodies  >2 publications with PTH1R and Lung
 Placenta Antibodies  >2 publications with PTH1R and Placenta
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