Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow PTPRN rightarrow Monoclonal PTPRN  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Collagen, type VII (COL7A1) Peptide
 • Ferritin light chain (FTL) Antibody
 • APE1 (APEX1) Antibody
 • Complement Component 5a (C5a) ELISA Kit
 • Fragile X Mental Retardation, Autosomal Homolog 1, L662 Antibody
 • Regulator Of Calcineurin 1 (RCAN1) ELISA Kit
 • 5'-AMP-activated protein kinase catalytic subunit alpha-1 (P... Recombinant Protein
 • Sex Determining Region Y Box Protein 18 (SOX18) ELISA Kit
 • COL4A4-Specific Antibody
 • MDM4 cDNA Clone
 • TOMM34 Antibody
 • v-abl Abelson murine leukemia viral oncogene homolog 2 (arg,... ELISA Kit
 • Baculoviral IAP repeat containing protein 2 (BIRC2) ELISA Kit
 • IL-37 (IL37) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-PTPRN antibody :: Mouse anti-Human PTPRN / IA-2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245594
Unit / Price
0.05 mg  /  $595 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PTPRN / IA-2, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Monoclonal [clone 8E3] (IgG2a,k) to Human PTPRN / IA-2

 Product Synonym Names    Anti-PTPRN / IA-2 Antibody (clone 8E3) IHC-plus; PTPRN; ICA512; IA2; ICA 512; Islet antigen 2; Islet cell antigen 2; Islet cell autoantigen 3; IA-2; Ia-2 antigen; ICA3; PTP-NP-2; PTP IA-2; R-PTP-N; IA-2/PTP; Islet cell antigen 512; Human PTPRN; IA-2
 Product Gene Name   

anti-PTPRN antibody

[Similar Products]
 Product Synonym Gene Name    IA-2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    601773
 3D Structure    ModBase 3D Structure for Q16849
Section Bar
 Clonality    Monoclonal
 Isotype    IgG2a,k
 Clone Number    8E3
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Specificity    Human PTPRN
 Purity/Purification    Protein A Purified
 Form/Format    PBS, pH 7.2
 Concentration    0.5 mg/ml (lot specific)
Section Bar
 Target Species    Human
 Immunogen Description    Recombinant protein
 Immunogen Type    Recombinant protein
Section Bar
 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-PTPRN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-PTPRN antibody

   PTPRN / IA-2 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
 Product Categories/Family for anti-PTPRN antibody    Family: Protein Phosphatase
Subfamily: R8
 Applications Tested/Suitable for anti-PTPRN antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-PTPRN antibody    ELISA, IHC-P (5 ug/ml), WB
Usage: Western Blot: Transfected lysate, Recombinant protein.
Section Bar
 Immunohistochemistry (IHC) of anti-PTPRN antibody    Anti-PTPRN antibody IHC of human pancreas, islets of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-PTPRN antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Western Blot (WB) of anti-PTPRN antibody    Western blot of PTPRN expression in transfected 293T cell line by PTPRN monoclonal antibody, clone 8E3.
anti-PTPRN antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PTPRN. It may not necessarily be applicable to this product.
 NCBI GI #    4506321
 NCBI GeneID    5798
 NCBI Accession #    NP_002837.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002846.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q16849 [Other Products]
 UniProt Secondary Accession #    Q08319; Q53QD6; Q6NSL1; B4DK12; F5GZS3 [Other Products]
 UniProt Related Accession #    Q16849 [Other Products]
 Molecular Weight    96,261 Da
Table BarTOPTable Bar
 NCBI Official Full Name    receptor-type tyrosine-protein phosphatase-like N isoform 1
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, receptor type, N
 NCBI Official Symbol    PTPRN [Similar Products]
 NCBI Official Synonym Symbols   
IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP
[Similar Products]
 NCBI Protein Information    receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N
 UniProt Protein Name    Receptor-type tyrosine-protein phosphatase-like N
 UniProt Synonym Protein Names   
Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2
 Protein Family    Receptor-type tyrosine-protein phosphatase
 UniProt Gene Name    PTPRN [Similar Products]
 UniProt Synonym Gene Names    ICA3; ICA512; R-PTP-N; ICA 512 [Similar Products]
 UniProt Entry Name    PTPRN_HUMAN
Section Bar
 NCBI Summary for PTPRN    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Section Bar
 UniProt Comments for PTPRN    PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor protein phosphatase, tyrosine; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q35-q36.1

Cellular Component: integral to membrane

Molecular Function: GTPase binding; protein binding; spectrin binding; protein tyrosine phosphatase activity

Biological Process: response to reactive oxygen species; response to cAMP; insulin secretion; response to estrogen stimulus; cytokine and chemokine mediated signaling pathway; response to glucose stimulus; protein amino acid dephosphorylation; response to insulin stimulus
Table BarTOPTable Bar
 Research Articles on PTPRN    1. Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-PTPRN antibodyPathways associated with anti-PTPRN antibody
 Reference Product  PubMed Publications
 PTPRT antibody  >23 publications with PTPRN and PTPRT
 INS antibody  >8 publications with PTPRN and INS
 MADD antibody  >1 publications with PTPRN and MADD
 PTPRS antibody  >1 publications with PTPRN and PTPRS
 GAD2 antibody  >1 publications with PTPRN and GAD2
 Products by Pathway  Pathway Diagram
 Type I Diabetes Mellitus Pathway antibodies  Type I Diabetes Mellitus Pathway Diagram
 Type I Diabetes Mellitus Pathway antibodies  Type I Diabetes Mellitus Pathway Diagram
Diseases associated with anti-PTPRN antibodyOrgans/Tissues associated with anti-PTPRN antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >196 publications with PTPRN and Immune System Diseases
 Nervous System Diseases Antibodies  >10 publications with PTPRN and Nervous System Diseases
 Disease Models, Animal Antibodies  >7 publications with PTPRN and Disease Models, Animal
 Brain Diseases Antibodies  >4 publications with PTPRN and Brain Diseases
 Kidney Diseases Antibodies  >3 publications with PTPRN and Kidney Diseases
 Weight Loss Antibodies  >2 publications with PTPRN and Weight Loss
 Inflammation Antibodies  >2 publications with PTPRN and Inflammation
 Liver Diseases Antibodies  >2 publications with PTPRN and Liver Diseases
 Congenital Abnormalities Antibodies  >1 publications with PTPRN and Congenital Abnormalities
 Edema Antibodies  >1 publications with PTPRN and Edema
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >131 publications with PTPRN and Pancreas
 Brain Antibodies  >29 publications with PTPRN and Brain
 Nerve Antibodies  >6 publications with PTPRN and Nerve
 Lung Antibodies  >6 publications with PTPRN and Lung
 Kidney Antibodies  >4 publications with PTPRN and Kidney
 Pituitary Gland Antibodies  >4 publications with PTPRN and Pituitary Gland
 Eye Antibodies  >4 publications with PTPRN and Eye
 Muscle Antibodies  >3 publications with PTPRN and Muscle
 Embryonic Tissue Antibodies  >2 publications with PTPRN and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions