NP_064714.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
pappalysin-2 isoform 1
NCBI Official Synonym Full Names
pappalysin 2
NCBI Protein Information
pappalysin-2; placenta-specific 3; pregnancy-associated plasma protein E1; pregnancy-associated plasma preproprotein-A2
UniProt Protein Name
Pappalysin-2
UniProt Synonym Protein Names
Pregnancy-associated plasma protein A2; PAPP-A2; Pregnancy-associated plasma protein E1
UniProt Synonym Gene Names
UniProt Entry Name
PAPP2_HUMAN
NCBI Summary for PAPPA2
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
UniProt Comments for PAPPA2
Function: Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3. Ref.1
Catalytic activity: Cleavage of the 143-Ser-|-Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5.
Cofactor: Binds 1 zinc ion per subunit
By similarity.
Subunit structure: Monomer.
Subcellular location: Secreted
By similarity.
Tissue specificity: Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas. Ref.1 Ref.2
Sequence similarities: Belongs to the peptidase M43B family.Contains 5 Sushi (CCP/SCR) domains.
Sequence caution: The sequence AAL17779.1 differs from that shown. Reason: Erroneous initiation. The sequence AAL17780.1 differs from that shown. Reason: Erroneous initiation. The sequence CAC11134.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on PAPPA2
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Products associated with anti-PAPPA2 antibody
Pathways associated with anti-PAPPA2 antibody
Diseases associated with anti-PAPPA2 antibody
Organs/Tissues associated with anti-PAPPA2 antibody
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