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anti-PTH antibody :: Mouse anti-Human Parathyroid Hormone (PTH) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS438914
Immunohistochemistry (IHC)
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Parathyroid Hormone (PTH), Monoclonal Antibody

★Popular Item★
 Also Known As   

Parathyroid Hormone (PTH) (N-Terminal) Mouse Monoclonal Antibody

 Product Synonym Names    hPTH; Parathormone; Parathyrin; Parathyroid hormone 1 (PTH1); Parathyroid hormone (PTH)
 Product Gene Name   

anti-PTH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146200
 3D Structure    ModBase 3D Structure for P01270
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 Clonality    Monoclonal
 Isotype    IgG2b, kappa
 Clone Number    SPM604
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cytoplasmic and Secreted
 Immunogen    A synthetic peptide from the N-terminal of human PTH polypeptide
 Hu-Chromosome Location    11p15.3-p15.1
 Positive Control    Human parathyroid gland carcinoma
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-PTH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PTH antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-PTH antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1.0ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of anti-PTH antibody    Formalin-fixed, paraffin-embedded human Parathyroid stained with PTH Monoclonal Antibody (SPM604).
anti-PTH antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PTH. It may not necessarily be applicable to this product.
 NCBI GI #    4506267
 NCBI GeneID    5741
 NCBI Accession #    NP_000306.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000315.3 [Other Products]
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 UniProt Primary Accession #    P01270 [Other Products]
 UniProt Secondary Accession #    Q4VB48; Q9UD38 [Other Products]
 UniProt Related Accession #    P01270 [Other Products]
 Molecular Weight    9kDa
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 NCBI Official Full Name    parathyroid hormone isoform 1 preproprotein
 NCBI Official Synonym Full Names    parathyroid hormone
 NCBI Official Symbol    PTH [Similar Products]
 NCBI Official Synonym Symbols   
PTH1
[Similar Products]
 NCBI Protein Information    parathyroid hormone
 UniProt Protein Name    Parathyroid hormone
 UniProt Synonym Protein Names   
Parathormone; Parathyrin
 Protein Family    Parathyroid hormone
 UniProt Gene Name    PTH [Similar Products]
 UniProt Synonym Gene Names    PTH [Similar Products]
 UniProt Entry Name    PTHY_HUMAN
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 NCBI Summary for PTH    This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
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 UniProt Comments for PTH    PTH: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Belongs to the parathyroid hormone family.

Protein type: Secreted, signal peptide; Hormone; Apoptosis; Secreted

Chromosomal Location of Human Ortholog: 11p15.3-p15.1

Cellular Component: extracellular region; extracellular space

Molecular Function: parathyroid hormone receptor binding; peptide hormone receptor binding; RNA polymerase II transcription factor activity, enhancer binding

Biological Process: bone resorption; cAMP metabolic process; G-protein coupled receptor protein signaling pathway; induction of apoptosis by hormones; negative regulation of transcription from RNA polymerase II promoter; positive regulation of bone mineralization; positive regulation of cAMP biosynthetic process; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression; skeletal development

Disease: Hypoparathyroidism, Familial Isolated
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Product References and Citations for anti-PTH antibody

   Watson, P.H. and Hanley, D.A. 1993. Parathyroid hormone: regulation of synthesis and secretion. Clin. Invest. Med. 16: 58-77.
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 Research Articles on PTH    1. Serum secreted i-PTH level might not be predictable by a total mass of parathyroid glands or by their blood supply.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PTH antibodyPathways associated with anti-PTH antibody
 Reference Product  PubMed Publications
 PTHLH antibody  >451 publications with PTH and PTHLH
 FGF23 antibody  >347 publications with PTH and FGF23
 CASR antibody  >283 publications with PTH and CASR
 PTH1R antibody  >244 publications with PTH and PTH1R
 AVP antibody  >62 publications with PTH and AVP
 PTH2R antibody  >19 publications with PTH and PTH2R
 CALCA antibody  >10 publications with PTH and CALCA
 BGLAP antibody  >3 publications with PTH and BGLAP
 GCG antibody  >1 publications with PTH and GCG
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Osteoblast Signaling Pathway antibodies  Osteoblast Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Vitamin D Synthesis Pathway antibodies  Vitamin D Synthesis Pathway Diagram
Diseases associated with anti-PTH antibodyOrgans/Tissues associated with anti-PTH antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3588 publications with PTH and Kidney Diseases
 Hyperparathyroidism, Secondary Antibodies  >3008 publications with PTH and Hyperparathyroidism, Secondary
 Bone Diseases, Metabolic Antibodies  >2818 publications with PTH and Bone Diseases, Metabolic
 Hypercalcemia Antibodies  >2560 publications with PTH and Hypercalcemia
 Renal Insufficiency Antibodies  >2349 publications with PTH and Renal Insufficiency
 Bone Resorption Antibodies  >2342 publications with PTH and Bone Resorption
 Osteoporosis Antibodies  >2250 publications with PTH and Osteoporosis
 Hypocalcemia Antibodies  >1498 publications with PTH and Hypocalcemia
 Cardiovascular Diseases Antibodies  >1026 publications with PTH and Cardiovascular Diseases
 Fractures, Bone Antibodies  >953 publications with PTH and Fractures, Bone
 Organ/Tissue Name  Pubmed Publications
 Parathyroid Antibodies  >16440 publications with PTH and Parathyroid
 Connective Tissue Antibodies  >2498 publications with PTH and Connective Tissue
 Embryonic Tissue Antibodies  >244 publications with PTH and Embryonic Tissue
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