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anti-PXN antibody :: Mouse Paxillin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175088
Testing Data
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Paxillin (PXN), Monoclonal Antibody

 Also Known As   

Anti-Paxillin antibody (monoclonal)

 Product Synonym Names    Paxillin; paxillin
 Product Gene Name   

anti-PXN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602505
 3D Structure    ModBase 3D Structure for P49023
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    PAX-14
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat, Chicken
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 Purity/Purification    Ascites
 Form/Format    Lyophilized
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 Immunogen    C-terminal part of recombinant chicken paxillin (amino acids 305-559).
 Contents    Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
 Reconstitution    1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PXN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PXN antibody

   Description: Mouse IgG monoclonal antibody for Paxillin, paxillin (PXN) detection. Tested with WB, ICC in Human, mouse, rat, chicken. No cross reactivity with other proteins. Uniprot ID: P49023
Background: The paxillin gene can be alternatively spliced to include 1 of 2 alternative exons, generating beta and gamma isoforms. Paxillin is a 68-kDa focal adhesion protein that is phosphorylated on tyrosine residues in fibroblasts in response to transformation by v-src, treatment with platelet-derived growth factor, or cross-linking of integrins. The 68-kD protein(paxillin) is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers in chicken embryo fibroblasts. It is also present in the focal adhesions of Madin-Darby bovine kidney(MDBK) epithelial cells but is absent, like talin, from the cell-cell adherens junctions of these cells.
 Applications Tested/Suitable for anti-PXN antibody   

Western Blot (WB), Immunocytochemistry (ICC)

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 Testing Data of anti-PXN antibody    anti-PXN antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for PXN. It may not necessarily be applicable to this product.
 NCBI GI #    317373486
 NCBI GeneID    5829
 NCBI Accession #    P49023.3 [Other Products]
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 UniProt Primary Accession #    P49023 [Other Products]
 UniProt Secondary Accession #    O14970; O14971; O60360; Q5HYA4; B2RAI3; B7ZMB4 [Other Products]
 UniProt Related Accession #    P49023 [Other Products]
 Molecular Weight    46,604 Da
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 NCBI Official Full Name    Paxillin
 NCBI Official Synonym Full Names    paxillin
 NCBI Official Symbol    PXN [Similar Products]
 NCBI Protein Information    paxillin
 UniProt Protein Name    Paxillin
 Protein Family    Paxillin
 UniProt Gene Name    PXN [Similar Products]
 UniProt Entry Name    PAXI_HUMAN
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 NCBI Summary for PXN    This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
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 UniProt Comments for PXN    PXN: a multi-domain cytoskeletal protein involved in actin-membrane attachment that localizes primarily to focal adhesion sites to the extracellular matrix. Phosphorylated by focal adhesion kinase (FAK) and is a component of integrin signaling. Its phosphorylation provides docking sites for recruitment of signaling molecules to focal adhesions. Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the Crk SH2 domain. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds DDEF2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.Three alternatively-spliced isoforms have been described. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase.

Protein type: Adaptor/scaffold; Cytoskeletal; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: nucleoplasm; microtubule associated complex; focal adhesion; lamellipodium; cytoplasm; stress fiber; plasma membrane; cell cortex; cytosol

Molecular Function: integrin binding; protein binding; zinc ion binding; beta-catenin binding; BH4 domain binding; protein kinase binding; vinculin binding

Biological Process: lamellipodium biogenesis; integrin-mediated signaling pathway; epidermal growth factor receptor signaling pathway; focal adhesion formation; peptidyl-tyrosine phosphorylation; activation of MAPK activity; signal complex assembly; cytoskeleton organization and biogenesis; signal transduction; regulation of cell shape; branching morphogenesis of a tube; muscle contraction; transforming growth factor beta receptor signaling pathway; cell adhesion; vascular endothelial growth factor receptor signaling pathway
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 Research Articles on PXN    1. Through HDAC6-dependent regulation of the microtubule cytoskeleton, paxillin regulates both Golgi organelle integrity and polarized cell invasion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Anti-Paxillin antibody (monoclonal)
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 MBS023121  Mouse Paxillin ELISA Kit  MBS036894  Rabbit Paxillin ELISA Kit
 MBS022895  Goat Paxillin ELISA Kit  MBS2059800  APC/CY7-Linked Polyclonal Antibody to Paxillin (Pax)
 MBS9403758  Paxillin (Ab-88) Antibody  MBS2059795  PE-Linked Polyclonal Antibody to Paxillin (Pax)
 MBS474049  phospho-Paxillin (Ser-178) Blocking Peptide  MBS631961  Paxillin, phosphorylated (Tyr118) (PXN)
 MBS2029236  Recombinant Paxillin (Pax)  MBS9309139  Human Paxillin (Pax) ELISA Kit
Products associated with anti-PXN antibodyPathways associated with anti-PXN antibody
 Reference Product  PubMed Publications
 PTK2 antibody  >356 publications with PXN and PTK2
 SRC antibody  >173 publications with PXN and SRC
 CRK antibody  >102 publications with PXN and CRK
 BCAR1 antibody  >69 publications with PXN and BCAR1
 PTK2B antibody  >32 publications with PXN and PTK2B
 GIT1 antibody  >16 publications with PXN and GIT1
 ITGA4 antibody  >15 publications with PXN and ITGA4
 ILK antibody  >9 publications with PXN and ILK
 PTPN12 antibody  >8 publications with PXN and PTPN12
 VCL antibody  >3 publications with PXN and VCL
 Products by Pathway  Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-extracellular Matrix Interactions Pathway antibodies  Cell-extracellular Matrix Interactions Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
Diseases associated with anti-PXN antibodyOrgans/Tissues associated with anti-PXN antibody
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >41 publications with PXN and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >33 publications with PXN and Breast Neoplasms
 Gastrointestinal Diseases Antibodies  >26 publications with PXN and Gastrointestinal Diseases
 Inflammation Antibodies  >25 publications with PXN and Inflammation
 Adenocarcinoma Antibodies  >22 publications with PXN and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >17 publications with PXN and Neoplasms, Experimental
 Necrosis Antibodies  >16 publications with PXN and Necrosis
 Cardiovascular Diseases Antibodies  >14 publications with PXN and Cardiovascular Diseases
 Ovarian Neoplasms Antibodies  >11 publications with PXN and Ovarian Neoplasms
 Vascular Diseases Antibodies  >11 publications with PXN and Vascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >110 publications with PXN and Blood
 Vascular Antibodies  >108 publications with PXN and Vascular
 Muscle Antibodies  >69 publications with PXN and Muscle
 Lung Antibodies  >49 publications with PXN and Lung
 Kidney Antibodies  >38 publications with PXN and Kidney
 Embryonic Tissue Antibodies  >29 publications with PXN and Embryonic Tissue
 Brain Antibodies  >28 publications with PXN and Brain
 Bone Antibodies  >27 publications with PXN and Bone
 Heart Antibodies  >23 publications with PXN and Heart
 Eye Antibodies  >20 publications with PXN and Eye
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