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anti-PlGF antibody :: Rat anti-Mouse PlGF, blocking antibody Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690032
Testing Data
Unit / Price
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PlGF, blocking antibody, Monoclonal Antibody

★Popular Item★
 Also Known As   

Rat Anti-Mouse PlGF, blocking antibody

 Product Synonym Names    Blocking antibody of mouse PlGF
 Product Gene Name   

anti-PlGF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000078.6 (85166637..85177785, complement). Location: 12 D; 12 39.58 cM
 3D Structure    ModBase 3D Structure for P49764
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 Clonality    Monoclonal
 Isotype    IgG2
 Clone Number    (9G33)
 Host    Rat
 Species Reactivity    Mouse
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 Specificity    This antibody recognizes mouse PlGF2 in Western blot. No cross reactivity to other species have not been tested!
 Purity/Purification    Protein G chromatography
 Form/Format    Lyophilized
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 Reconstitution    Reconstitute the antibody with 400 ul sterile PBS and the final concentration is 500 ug/ml.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-PlGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PlGF antibody

   Placenta growth factor (PlGF) is a member of the PDGF/VEGF family of growth factors that share a conserved pattern of eight cysteines. Alternate splicing results in at least three human mature PlGF forms containing 131 (PlGF-1), 152 (PlGF-2), and 203 (PlGF-3) amino acids (aa) respectively. Only PlGF-2 contains a highly basic heparin-binding 21 aa insert at the C-terminus. In the mouse, only one P lGF that is the equivalent of human PlGF-2 has been identified. Mouse PlGF shares 60%, 92%, 62% and 59% aa identity with the appropriate isoform of human, rat, canine and equine PlGF. PlGF is mainly found as variably glycosylated, secreted, 55 - 60 kDa disulfide linked homodimers. Mammalian cells expressing PlGF include villous trophoblasts, decidual cells, erythroblasts, keratinocytes and some endothelial cells. Circulating PlGF increases during human pregnancy, reaching a peak in mid-gestationÍž this increase is attenuated in preeclampsia. However, deletion of PlGF in the mouse does not affect development or reproduction. Postnatally, mice lacking PlGF show impaired angiogenesis in response to ischemia. PlGF binds and signals through VEGF R1/Flt-1, but not VEGF R2/Flk-1/KDR, while VEGF binds both but signals only through the angiogenic receptor, VEGF R2. PlGF and VEGF therefore compete for binding to VEGF R1, allowing high PlGF to discourage VEGF/VEGF R1 binding and promote VEGF/VEGF R2-mediated angiogenesis. However, PlGF (especially human PlGF-1) and some forms of VEGF can form dimers that decrease the angiogenic effect of VEGF on VEGF R2. PlGF-2, like VEGF164/165, shows heparin-dependent binding of neuropilin (Npn)-1 and Npn-2 and can inhibit nerve growth cone collapse. PlGF induces monocyte activation, migration, and production of inflammatory cytokines and VEGF. These activities facilitate wound and bone fracture healing, but also contribute to inflammation in active sickle cell disease and atherosclerosis. Circulating PlGF often correlates with tumor stage and aggressiveness, and therapeutic PlGF antibodies are being investigated to inhibit tumor growth and angiogenesis. The functional antibody will block the binding of PlGF to Flt-1/VEGFR-1
 Application Notes for anti-PlGF antibody    1. Blocking PlGF-2 induced VEGFR-1 phosphorylation in endothelial cells 2. Western blot: Yes Optimal dilutions should be determined by each laboratory for each application.
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 Testing Data of anti-PlGF antibody    anti-PlGF antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for PlGF. It may not necessarily be applicable to this product.
 NCBI GI #    6679289
 NCBI GeneID    18654
 NCBI Accession #    NP_032853.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_008827.3 [Other Products]
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 UniProt Primary Accession #    P49764 [Other Products]
 UniProt Related Accession #    P49764 [Other Products]
 Molecular Weight    17,876 Da
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 NCBI Official Full Name    placenta growth factor isoform 1
 NCBI Official Synonym Full Names    placental growth factor
 NCBI Official Symbol    Pgf [Similar Products]
 NCBI Official Synonym Symbols   
PIGF; Plgf; AI854365
[Similar Products]
 NCBI Protein Information    placenta growth factor
 UniProt Protein Name    Placenta growth factor
 UniProt Gene Name    Pgf [Similar Products]
 UniProt Synonym Gene Names    Plgf; PlGF [Similar Products]
 UniProt Entry Name    PLGF_MOUSE
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 UniProt Comments for PlGF    Function: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth

By similarity.

Subunit structure: Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF

By similarity.

Subcellular location: Secreted

By similarity.

Sequence similarities: Belongs to the PDGF/VEGF growth factor family.
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 Research Articles on PlGF    1. PlGF positively and negatively modulate tumor growth, angiogenesis, and vascular remodeling through a VEGF-dependent mechanism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PlGF antibodyPathways associated with anti-PlGF antibody
 Reference Product  PubMed Publications
 Vegfa antibody  >24 publications with PlGF and Vegfa
 Flt1 antibody  >16 publications with PlGF and Flt1
 Kdr antibody  >11 publications with PlGF and Kdr
 Vegfc antibody  >8 publications with PlGF and Vegfc
 Vegfb antibody  >5 publications with PlGF and Vegfb
 Nrp1 antibody  >3 publications with PlGF and Nrp1
 Flt4 antibody  >3 publications with PlGF and Flt4
 Akt1 antibody  >2 publications with PlGF and Akt1
 Figf antibody  >2 publications with PlGF and Figf
 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with anti-PlGF antibodyOrgans/Tissues associated with anti-PlGF antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >374 publications with PlGF and Cardiovascular Diseases
 Inflammation Antibodies  >281 publications with PlGF and Inflammation
 Hypertension Antibodies  >195 publications with PlGF and Hypertension
 Disease Models, Animal Antibodies  >156 publications with PlGF and Disease Models, Animal
 Necrosis Antibodies  >151 publications with PlGF and Necrosis
 Neoplasms Antibodies  >150 publications with PlGF and Neoplasms
 Lung Diseases Antibodies  >126 publications with PlGF and Lung Diseases
 Heart Diseases Antibodies  >124 publications with PlGF and Heart Diseases
 Atherosclerosis Antibodies  >91 publications with PlGF and Atherosclerosis
 Brain Diseases Antibodies  >71 publications with PlGF and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >237 publications with PlGF and Lung
 Brain Antibodies  >195 publications with PlGF and Brain
 Embryonic Tissue Antibodies  >195 publications with PlGF and Embryonic Tissue
 Liver Antibodies  >135 publications with PlGF and Liver
 Eye Antibodies  >82 publications with PlGF and Eye
 Stomach Antibodies  >69 publications with PlGF and Stomach
 Intestine Antibodies  >62 publications with PlGF and Intestine
 Pituitary Gland Antibodies  >32 publications with PlGF and Pituitary Gland
 Extraembryonic Tissue Antibodies  >31 publications with PlGF and Extraembryonic Tissue
 Spinal Cord Antibodies  >28 publications with PlGF and Spinal Cord
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