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anti-PLG antibody :: Mouse Plasminogen Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS190253 anti-PLG antibody
Unit / Price
0.5 mg  /  $265 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Plasminogen (PLG), Monoclonal Antibody

 Also Known As   

Human Plasminogen Monoclonal Antibody

 Product Synonym Names    Anti-Plasminogen; Plasminogen
 Product Gene Name   

anti-PLG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (161123225..161175086). Location: 6q26
 OMIM    173350
 3D Structure    ModBase 3D Structure for P00747
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 Clonality    Monoclonal
 Isotype    IgG2a
 Host    Mouse
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 Specificity    Anti-Plasminogen [Three murine MAbs recognize human plasminogen.]
These antibodies are specific for human plasminogen.
 Form/Format    500 ug Protein A-purified antibody in PBS, pH 7.4.
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 Antigen    Purified human plasminogen.
 Stabilizer    None
 Preservatives    0.1% sodium azide.
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles
 Other Notes    Small volumes of anti-PLG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-PLG antibody    Hormone and Serum Protein Antibodies
 Applications Tested/Suitable for anti-PLG antibody   

Immunoassay, Immunohistochemistry

 Application Notes for anti-PLG antibody    These antibodies may be used in immunoassays to detect/quantitate human plasminogen. They may also be used to affinity purify plasminogen and in immunohistochemistry on formalin-fixed/paraffin embedded tissues.
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NCBI/Uniprot data below describe general gene information for PLG. It may not necessarily be applicable to this product.
 NCBI GI #    4505881
 NCBI GeneID    5340
 NCBI Accession #    NP_000292.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000301.3 [Other Products]
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 UniProt Primary Accession #    P00747 [Other Products]
 UniProt Secondary Accession #    Q15146; Q5TEH4; Q6PA00 [Other Products]
 UniProt Related Accession #    P00747; Q5TEH5; Q68DS2; Q9UBQ9; Q9UMI2 [Other Products]
 Molecular Weight    90,569 Da [Similar Products]
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 NCBI Official Full Name    plasminogen isoform 1
 NCBI Official Synonym Full Names    plasminogen
 NCBI Official Symbol    PLG [Similar Products]
 NCBI Official Synonym Symbols   
DKFZp779M0222
[Similar Products]
 NCBI Protein Information    plasminogen; OTTHUMP00000017544; OTTHUMP00000017545; OTTHUMP00000197002
 UniProt Protein Name    Plasminogen
 Protein Family    Plasminogen
 UniProt Gene Name    PLG [Similar Products]
 UniProt Entry Name    PLMN_HUMAN
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 NCBI Summary for PLG    The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
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 UniProt Comments for PLG    Plasminogen: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Defects in PLG are the cause of plasminogen deficiency (PLGD). PLGD is characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa. Belongs to the peptidase S1 family. Plasminogen subfamily.

Protein type: Protease; Secreted; EC 3.4.21.7; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: extracellular space; cell surface; extrinsic to external side of plasma membrane; plasma membrane; extracellular region

Molecular Function: protein domain specific binding; protein binding; serine-type peptidase activity; serine-type endopeptidase activity; apolipoprotein binding; receptor binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; tissue remodeling; myoblast differentiation; muscle maintenance; extracellular matrix disassembly; negative regulation of cell proliferation; fibrinolysis; negative regulation of fibrinolysis; cellular protein metabolic process; platelet degranulation; proteolysis involved in cellular protein catabolic process; tissue regeneration; positive regulation of fibrinolysis; blood coagulation; transmembrane transport

Disease: Plasminogen Deficiency, Type I
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 Research Articles on PLG    1. The study shows that the alternative pathway for plasmin-mediated fibrinolysis by leukocyte elastase is activated, and contributes to the degradation of cross-linked fibrin in sepsis-induced disseminated intravascular coagulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLG antibodyPathways associated with anti-PLG antibody
 Reference Product  PubMed Publications
 SERPINE1 antibody  >40 publications with PLG and SERPINE1
 NGF antibody  >6 publications with PLG and NGF
 Products by Pathway  Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
Diseases associated with anti-PLG antibodyOrgans/Tissues associated with anti-PLG antibody
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >88 publications with PLG and Vascular Diseases
 Nervous System Diseases Antibodies  >77 publications with PLG and Nervous System Diseases
 Thrombosis Antibodies  >73 publications with PLG and Thrombosis
 Neoplasms Antibodies  >70 publications with PLG and Neoplasms
 PLASMINOGEN DEFICIENCY, TYPE I Antibodies  >52 publications with PLG and PLASMINOGEN DEFICIENCY, TYPE I
 Liver Diseases Antibodies  >35 publications with PLG and Liver Diseases
 Inflammation Antibodies  >35 publications with PLG and Inflammation
 Blood Coagulation Disorders Antibodies  >29 publications with PLG and Blood Coagulation Disorders
 Hemorrhage Antibodies  >21 publications with PLG and Hemorrhage
 Lung Diseases Antibodies  >19 publications with PLG and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >357 publications with PLG and Blood
 Brain Antibodies  >111 publications with PLG and Brain
 Liver Antibodies  >70 publications with PLG and Liver
 Lung Antibodies  >34 publications with PLG and Lung
 Spleen Antibodies  >23 publications with PLG and Spleen
 Embryonic Tissue Antibodies  >17 publications with PLG and Embryonic Tissue
 Kidney Antibodies  >17 publications with PLG and Kidney
 Heart Antibodies  >16 publications with PLG and Heart
 Pancreas Antibodies  >4 publications with PLG and Pancreas
 Mammary Gland Antibodies  >3 publications with PLG and Mammary Gland
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