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anti-PLG antibody :: Mouse Plasminogen Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS311192 anti-PLG antibody
Unit / Price
1 mg  /  $535 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Plasminogen (PLG), Monoclonal Antibody

★Popular Item★
 Also Known As   

MAb to Plasminogen

 Product Synonym Names    Monoclonal Antibody to Human Plasminogen
 Product Gene Name   

anti-PLG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (161123225..161175086). Location: 6q26
 OMIM    173350
 3D Structure    ModBase 3D Structure for P00747
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    5H3
 Host    Mouse
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 Specificity    Reacts with human Plasminogen, plasmin and angiostatin. Does not crossreact with other human serum proteins.
 Purity/Purification    >90% pure (SDS-PAGE). Ion exchange chromatography
 Form/Format    Purified, Liquid
 Concentration    8.6 mg/ml (OD280nm, E0.1% = 1.4) (lot specific)
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 Source    Ascites
 Immunogen    Purified human plasminogen
 Affinity Constant    Not determined
 Buffer    Phosphate Buffered Saline,pH 7.4
 Preservative    0.09% Sodium azide
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Store at 2-8C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PLG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-PLG antibody    Monoclonal Antibodies to Platelets and Hemostasis Antigens
 Applications Tested/Suitable for anti-PLG antibody   

EIA/ELISA, Immunohistochemistry, Immunoassay Antibody Pairs

 Application Notes for anti-PLG antibody    Affinity purification of human plasminogen.
Detection of plasminogen in ELISA and immunohistochemistry.
Works in immunohistochemistry on formalin-fixed and paraffin embedded sections.

Each laboratory should determine an optimum working titer for in its particular application.

Other applications have not been tested but use in such assayss should not necessarily be excluded.
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NCBI/Uniprot data below describe general gene information for PLG. It may not necessarily be applicable to this product.
 NCBI GI #    4505881
 NCBI GeneID    5340
 NCBI Accession #    NP_000292.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000301.3 [Other Products]
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 UniProt Primary Accession #    P00747 [Other Products]
 UniProt Secondary Accession #    Q15146; Q5TEH4; Q6PA00 [Other Products]
 UniProt Related Accession #    P00747; Q5TEH5; Q68DS2; Q9UBQ9; Q9UMI2 [Other Products]
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 NCBI Official Full Name    plasminogen isoform 1
 NCBI Official Synonym Full Names    plasminogen
 NCBI Official Symbol    PLG [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    plasminogen; OTTHUMP00000017544; OTTHUMP00000017545; OTTHUMP00000197002
 UniProt Protein Name    Plasminogen
 Protein Family    Plasminogen
 UniProt Gene Name    PLG [Similar Products]
 UniProt Entry Name    PLMN_HUMAN
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 NCBI Summary for PLG    The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
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 UniProt Comments for PLG    Function: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Ref.26Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. Ref.26

Catalytic activity: Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products. Ref.29

Enzyme regulation: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase. Plasmin activity inhibited by SERPINE2. Ref.26

Subunit structure: Interacts (both mature PLG and the angiostatin peptide) with CSPG4 and AMOT. Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation

By similarity. Ref.19 Ref.24 Ref.25 Ref.27 Ref.30

Subcellular location: Secreted. Note: Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface. Ref.24 Ref.26

Tissue specificity: Present in plasma and many other extracellular fluids. It is synthesized in the liver.

Domain: Kringle domains mediate interaction with CSPG4. Ref.25

Post-translational modification: N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.

Involvement in disease: Defects in PLG are a cause of susceptibility to thrombosis (THR) [

MIM:188050]. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Ref.48 Ref.51 Ref.52 Ref.53Defects in PLG are the cause of plasminogen deficiency (PLGD) [

MIM:217090]. PLGD is characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa. Ref.48 Ref.50 Ref.51 Ref.52 Ref.53 Ref.54 Ref.55 Ref.56

Miscellaneous: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.

Sequence similarities: Belongs to the peptidase S1 family. Plasminogen subfamily.Contains 5 kringle domains.Contains 1 PAN domain.Contains 1 peptidase S1 domain.
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 Research Articles on PLG    1. The study shows that the alternative pathway for plasmin-mediated fibrinolysis by leukocyte elastase is activated, and contributes to the degradation of cross-linked fibrin in sepsis-induced disseminated intravascular coagulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLG antibodyPathways associated with anti-PLG antibody
 Reference Product  PubMed Publications
 SERPINE1 antibody  >40 publications with PLG and SERPINE1
 NGF antibody  >6 publications with PLG and NGF
 Products by Pathway  Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
Diseases associated with anti-PLG antibodyOrgans/Tissues associated with anti-PLG antibody
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >88 publications with PLG and Vascular Diseases
 Nervous System Diseases Antibodies  >77 publications with PLG and Nervous System Diseases
 Thrombosis Antibodies  >73 publications with PLG and Thrombosis
 Neoplasms Antibodies  >70 publications with PLG and Neoplasms
 Liver Diseases Antibodies  >35 publications with PLG and Liver Diseases
 Inflammation Antibodies  >35 publications with PLG and Inflammation
 Blood Coagulation Disorders Antibodies  >29 publications with PLG and Blood Coagulation Disorders
 Hemorrhage Antibodies  >21 publications with PLG and Hemorrhage
 Lung Diseases Antibodies  >19 publications with PLG and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >357 publications with PLG and Blood
 Brain Antibodies  >111 publications with PLG and Brain
 Liver Antibodies  >70 publications with PLG and Liver
 Lung Antibodies  >34 publications with PLG and Lung
 Spleen Antibodies  >23 publications with PLG and Spleen
 Embryonic Tissue Antibodies  >17 publications with PLG and Embryonic Tissue
 Kidney Antibodies  >17 publications with PLG and Kidney
 Heart Antibodies  >16 publications with PLG and Heart
 Pancreas Antibodies  >4 publications with PLG and Pancreas
 Mammary Gland Antibodies  >3 publications with PLG and Mammary Gland
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