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anti-PDGFAA antibody :: Mouse anti-Human Platelet Derived Growth Factor AA (PDGFAA) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2012496 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Western Blot (WB)
Unit / Price
0.01 mg  /  $90 +1 FREE 8GB USB
0.02 mg  /  $100 +1 FREE 8GB USB
0.05 mg  /  $130 +1 FREE 8GB USB
0.1 mg  /  $160 +1 FREE 8GB USB
0.2 mg  /  $200 +1 FREE 8GB USB
1 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Platelet Derived Growth Factor AA (PDGFAA), Monoclonal Antibody

★Popular Item★
 Also Known As   

Monoclonal Antibody to Platelet Derived Growth Factor AA (PDGFAA)

 Product Gene Name   

anti-PDGFAA antibody

[Similar Products]
 Matching Pairs    Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2012496)
Antigen: Platelet Derived Growth Factor AA (PDGFAA) (MBS2009329)
 Matching Pairs    Unconjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2012496)
APC-CY7 Conjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2043341)
 Matching Pairs    Unconjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2012496)
PE Conjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2043343)
 Matching Pairs    Unconjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2012496)
APC-CY7 Conjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2043345)
 Matching Pairs    Unconjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2012496)
Cy3 Conjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2043347)
 Matching Pairs    Unconjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2012496)
FITC Conjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2043348)
 Matching Pairs    Unconjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2012496)
HRP Conjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2043350)
 Matching Pairs    Unconjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2012496)
Biotin Conjugated Secondary Antibody: IgG (MBS2086030)
 Matching Pairs    Unconjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2012496)
FITC Conjugated Secondary Antibody: IgG (MBS2086031)
 Matching Pairs    Unconjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2012496)
Biotin Conjugated Secondary Antibody: IgG (MBS2086033)
 Matching Pairs    Unconjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2012496)
FITC Conjugated Secondary Antibody: IgG (MBS2086034)
 Matching Pairs    Unconjugated Antibody: Platelet Derived Growth Factor AA (PDGFAA) (MBS2012496)
HRP Conjugated Secondary Antibody: IgG (MBS2086035)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-SIEE AVPAVCKTRT VIYEIPRSQV DPTSANFLIW PPCVEVKRCT GCCNTSSVKC QPSRVHHRSV KVAKVEYVRK KPKLKEVQVR LEEHLECACA
 OMIM    X03795 mRNA
 3D Structure    ModBase 3D Structure for P04085
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 Clonality    Monoclonal
 Isotype    IgG
 Host    Mouse
 Species Reactivity    Human
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 Specificity    The antibody is a mouse monoclonal antibody raised against PDGFAA. It has been selected for its ability to recognize PDGFAA in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    500ug/ml (lot specific)
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 Immunogen    Recombinant PDGFAA (Ser87~Thr211) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2043345
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-PDGFAA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PDGFAA antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-PDGFAA antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-PDGFAA antibody    (Figure.Western Blot;Sample: Recombinant PDGFAA, Human.)
anti-PDGFAA antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PDGFAA. It may not necessarily be applicable to this product.
 NCBI GI #    77695917
 NCBI GeneID    5154
 NCBI Accession #    NP_002598.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_002607.5 [Other Products]
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 UniProt Primary Accession #    P04085 [Other Products]
 UniProt Secondary Accession #    B5BU73 [Other Products]
 UniProt Related Accession #    P04085 [Other Products]
 Molecular Weight    22,253 Da
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 NCBI Official Full Name    platelet-derived growth factor subunit A isoform 1 preproprotein
 NCBI Official Synonym Full Names    platelet derived growth factor subunit A
 NCBI Official Symbol    PDGFA [Similar Products]
 NCBI Official Synonym Symbols   
PDGF1; PDGF-A
[Similar Products]
 NCBI Protein Information    platelet-derived growth factor subunit A
 UniProt Protein Name    Platelet-derived growth factor subunit A
 UniProt Synonym Protein Names   
PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide
 UniProt Gene Name    PDGFA [Similar Products]
 UniProt Synonym Gene Names    PDGF1; PDGF subunit A [Similar Products]
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 NCBI Summary for PDGFAA    This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
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 UniProt Comments for PDGFAA    PDGFA: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p22.3

Cellular Component: cell surface; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen; Golgi membrane; microvillus

Molecular Function: collagen binding; growth factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: actin cytoskeleton organization; alveolus development; angiogenesis; cell activation; cell projection assembly; cell-cell signaling; extracellular matrix organization; hair follicle development; MAPK cascade; negative chemotaxis; negative regulation of phosphatidylinositol biosynthetic process; organ morphogenesis; phosphatidylinositol phosphorylation; phosphoinositide-mediated signaling; platelet degranulation; platelet-derived growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of fibroblast proliferation; positive regulation of GTPase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of protein kinase B signaling; regulation of actin cytoskeleton organization; regulation of peptidyl-tyrosine phosphorylation; regulation of phosphatidylinositol 3-kinase signaling; regulation of smooth muscle cell migration; response to wounding; skin development; wound healing
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 Research Articles on PDGFAA    1. Tumor cell induced mesenchymal stromal cell chemotaxis appears to be mediated through paracrine secretion of PDGF-AA.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PDGFAA antibodyPathways associated with anti-PDGFAA antibody
 Reference Product  PubMed Publications
 PDGFRA antibody  >40 publications with PDGFAA and PDGFRA
 PDGFB antibody  >28 publications with PDGFAA and PDGFB
 PDGFRB antibody  >20 publications with PDGFAA and PDGFRB
 EGFR antibody  >9 publications with PDGFAA and EGFR
 FLT1 antibody  >2 publications with PDGFAA and FLT1
 FGF1 antibody  >2 publications with PDGFAA and FGF1
 SP1 antibody  >1 publications with PDGFAA and SP1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Diseases associated with anti-PDGFAA antibodyOrgans/Tissues associated with anti-PDGFAA antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >49 publications with PDGFAA and Neoplasms
 Carcinoma Antibodies  >17 publications with PDGFAA and Carcinoma
 Adenocarcinoma Antibodies  >12 publications with PDGFAA and Adenocarcinoma
 Inflammation Antibodies  >9 publications with PDGFAA and Inflammation
 Neoplasms, Experimental Antibodies  >5 publications with PDGFAA and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >4 publications with PDGFAA and Cell Transformation, Neoplastic
 Cardiovascular Diseases Antibodies  >4 publications with PDGFAA and Cardiovascular Diseases
 Brain Diseases Antibodies  >4 publications with PDGFAA and Brain Diseases
 Lung Diseases Antibodies  >4 publications with PDGFAA and Lung Diseases
 Hyperplasia Antibodies  >3 publications with PDGFAA and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >9 publications with PDGFAA and Liver
 Lung Antibodies  >9 publications with PDGFAA and Lung
 Brain Antibodies  >8 publications with PDGFAA and Brain
 Embryonic Tissue Antibodies  >6 publications with PDGFAA and Embryonic Tissue
 Kidney Antibodies  >5 publications with PDGFAA and Kidney
 Connective Tissue Antibodies  >5 publications with PDGFAA and Connective Tissue
 Mouth Antibodies  >5 publications with PDGFAA and Mouth
 Ovary Antibodies  >4 publications with PDGFAA and Ovary
 Heart Antibodies  >4 publications with PDGFAA and Heart
 Nerve Antibodies  >3 publications with PDGFAA and Nerve
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