Q9UIW2
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UniProt Related Accession #
NCBI Official Full Name
plexin A1, isoform CRA_c
NCBI Official Synonym Full Names
plexin A1
NCBI Official Synonym Symbols
NOV; NOVP; PLXN1; PLEXIN-A1; DKFZp761P19121 [Similar Products]
NCBI Protein Information
plexin-A1; plexin 1; OTTHUMP00000215966; semaphorin receptor NOV
UniProt Protein Name
Plexin-A1
UniProt Synonym Protein Names
Semaphorin receptor NOV
UniProt Synonym Gene Names
UniProt Entry Name
PLXA1_HUMAN
UniProt Comments for PLXNA1
PLXNA1: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Detected in fetal brain, lung, liver and kidney. Belongs to the plexin family.
Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component: cytoplasm; plasma membrane; integral to membrane; nucleus
Molecular Function: semaphorin receptor activity; receptor activity
Biological Process: axon guidance; regulation of smooth muscle cell migration; multicellular organismal development
Research Articles on PLXNA1
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Products associated with anti-PLXNA1 antibody
Pathways associated with anti-PLXNA1 antibody
Diseases associated with anti-PLXNA1 antibody
Organs/Tissues associated with anti-PLXNA1 antibody
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