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anti-pab-1 antibody :: Mouse Poly(A)-binding Protein 1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS608034 anti-pab-1 antibody
Unit / Price
0.1 mL  /  $540 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Poly(A)-binding Protein 1 (pab-1), Monoclonal Antibody

 Also Known As   

Poly(A)-binding Protein 1 (PABP1, PABP-1, PBP1, PAB1, PABP, PABPC1, PABPC2, PABPL1, Poly(A)-binding Protein Cytoplasmic 1, Polyadenylate Binding Protein 1)

 Product Synonym Names    Anti -Poly(A)-binding Protein 1 (PABP1, PABP-1, PBP1, PAB1, PABP, PABPC1, PABPC2, PABPL1, Poly(A)-binding Protein Cytoplasmic 1, Polyadenylate Binding Protein 1)
 Product Gene Name   

anti-pab-1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: I; NC_003279.6 (10432805..10435866, complement)
 3D Structure    ModBase 3D Structure for Q7K798
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    9A381
 Host    Mouse
 Species Reactivity    Bovine, Canine, Hamster, Human, Monkey, Xenopus
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 Specificity    Recognizes human Poly(A)-binding Protein 1 at ~69kD. Species Crossreactivity: monkey, bovine, hamster, canine and Xenopus
 Purity/Purification    Affinity Purified
Purified
 Form/Format    Supplied as a liquid in 0.01M PBS, pH 7.4, 15mM sodium azide.
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 Immunogen    Recombinant protein corresponding to human Poly(A)-binding Protein 1.
 Hybridoma    Sp2/0 myeloma cells with spleen cells from Balb/c mice.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
 Other Notes    Small volumes of anti-pab-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-pab-1 antibody

   Stability and translation of mRNA in the cytoplasm is governed by different proteins, among them the PABP protein (poly(A)-binding protein). This protein, which is found in the cytoplasm, binds to the 3'-poly(A) tail of mRNA transcripts. PABP is found in excess, relative to the amount of cytoplasmic poly(A) (three fold) and binds to its poly(A) target at high affinity (Kd of 7nM). PABP is highly conserved between different organisms especially at the amino-terminal region of the protein that contains four RNA-binding domains (RBDs). These domains are important for the binding of the poly(A) tail of mRNA. Most mRNAs in eukaryotic cells contain a cap structure in their 5' end (m7GpppX). This structure is recognized by the EIF4F complex, which interacts with PABP indirectly via the PAIP-1 protein (PABP-interacting protein-1). As a consequence, an interaction between the 5' and 3' ends of mRNA occurs. This proximity between the mRNA ends contributes to its stability and enhances translation, since terminating ribosomes may start translation again.
 Product Categories/Family for anti-pab-1 antibody    Antibodies; Abs to RNA Processing
 Applications Tested/Suitable for anti-pab-1 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

 Application Notes for anti-pab-1 antibody    Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunocytochemistry.
Dilution: Western Blot: 0.5ug/ml labels PABP1 using whole cell extract of HEK 293T cells.
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NCBI/Uniprot data below describe general gene information for pab-1. It may not necessarily be applicable to this product.
 NCBI GI #    71993209
 NCBI GeneID    172920
 NCBI Accession #    NP_001021710.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001026539.2 [Other Products]
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 UniProt Primary Accession #    Q7K798 [Other Products]
 UniProt Related Accession #    Q7K798 [Other Products]
 Molecular Weight    64,768 Da [Similar Products]
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 NCBI Official Full Name    PolyA Binding protein family member (pab-1)
 NCBI Official Symbol    pab-1 [Similar Products]
 NCBI Protein Information    PolyA Binding protein family member (pab-1)
 UniProt Protein Name    Protein Y106G6H.2b, partially confirmed by transcript evidence
 UniProt Gene Name    pab-1 [Similar Products]
 UniProt Entry Name    Q7K798_CAEEL
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 UniProt Comments for pab-1    Binds the poly(A) tail of mRNA.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-pab-1 antibodyOrgans/Tissues associated with anti-pab-1 antibody
 Products by Pathway  Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 Translation Factors Pathway antibodies  Translation Factors Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram
 MRNA Surveillance Pathway antibodies  MRNA Surveillance Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Unknown Developmental Stage Antibodies  >1 publications with pab-1 and Unknown Developmental Stage
 Embryo Antibodies  >1 publications with pab-1 and Embryo
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