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anti-DLG4 antibody :: Mouse Postsynaptic Density Protein 95 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS600612 anti-DLG4 antibody
Unit / Price
0.1 mg  /  $680 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Postsynaptic Density Protein 95 (DLG4), Monoclonal Antibody

 Also Known As   

Postsynaptic Density Protein 95 (PSD-95, PSD95, Discs Large Homolog 4, DLG4, Post-synaptic Density Protein 95, Synapse-associated Protein 90, SAP90, SAP-90)

 Product Synonym Names    Anti -Postsynaptic Density Protein 95 (PSD-95, PSD95, Discs Large Homolog 4, DLG4, Post-synaptic Density Protein 95, Synapse-associated Protein 90, SAP90, SAP-90)
 Product Gene Name   

anti-DLG4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (7093209..7123369, complement). Location: 17p13.1
 OMIM    602887
 3D Structure    ModBase 3D Structure for P78352
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    2Q128
 Host    Mouse
 Species Reactivity    Bovine, Mouse, Rat
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 Specificity    Reacts with recombinant rat PSD-95 and identifies a band at approximately 95kD, corresponding to PSD-95, on immunoblots of rat brain, mouse brain and bovine brain extracts. Also present in rat brain and mouse brain tissue extracts are bands of approximately 80kD and 50kD. PSD-95 is believed to initiate NMDA receptor clustering on the post synaptic membrane.
 Purity/Purification    Purified
Purified immunoglobulin
 Form/Format    Liquid in PBS. Contains no preservative.
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 Immunogen    Recombinant rat PSD-95
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 Preparation and Storage    -20 degree C
 Other Notes    Small volumes of anti-DLG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-DLG4 antibody    Antibodies; Abs to Neuroscience
 Applications Tested/Suitable for anti-DLG4 antibody   

Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-DLG4 antibody    Western Blot: 1:1000 (ECL) Immunofluorescence
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NCBI/Uniprot data below describe general gene information for DLG4. It may not necessarily be applicable to this product.
 NCBI GI #    3318653
 NCBI GeneID    1742
 NCBI Accession #    AAC52113.1 [Other Products]
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 UniProt Primary Accession #    P78352 [Other Products]
 UniProt Secondary Accession #    Q92941; Q9UKK8; B7Z1S1; G5E939 [Other Products]
 UniProt Related Accession #    P78352 [Other Products]
 Molecular Weight    80,495 Da [Similar Products]
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 NCBI Official Full Name    post-synaptic density protein 95
 NCBI Official Synonym Full Names    discs, large homolog 4 (Drosophila)
 NCBI Official Symbol    DLG4 [Similar Products]
 NCBI Official Synonym Symbols   
PSD95; SAP90; SAP-90
[Similar Products]
 NCBI Protein Information    disks large homolog 4; discs large homolog 4; Tax interaction protein 15; synapse-associated protein 90; postsynaptic density protein 95; post-synaptic density protein 95
 UniProt Protein Name    Disks large homolog 4
 UniProt Synonym Protein Names   
Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90
 Protein Family    Disks large
 UniProt Gene Name    DLG4 [Similar Products]
 UniProt Synonym Gene Names    PSD95; PSD-95; SAP-90; SAP90 [Similar Products]
 UniProt Entry Name    DLG4_HUMAN
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 NCBI Summary for DLG4    This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DLG4    PSD-95: a membrane associated guanylate kinase (MAGUK) scaffolding protein located in neural postsynaptic densities. Associates with NMDA receptor NR2 subunits via glutamate serine (aspartate/glutamate) valine motifs in the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Its overexpression or depletion changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the channel intracellularly. Binds tissue-type plasminogen activator (tPA), mediating neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. Interacts through its first two PDZ domains with NMDAR2A, NMDAR2B, NMDAR2C, NMDAR2D, ACCN3, certain splice forms of NMDAR1, KV4.2, CXADR and synGAP. Interacts through its first two PDZ domains with Kv1.1, Kv1.2, Kv1.3, Kv1.4 and HER4. Interacts through its first PDZ domain with GluR6 and Kv1.4. Interacts through its second PDZ domain with the PDZ domain of nNOS or the C-terminus of NOS1AP. May interact with 5-HT(2A). Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with SAPAP1, SAPAP2, SAPAP3, SAPAP4, MAP1A, and BEGAIN. Interacts through its guanylate kinase-like domain with KIF13B. Two alternatively spliced human isoforms have been reported. Palmitoylation of isoform 1 is required for targeting to postsynaptic density.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cortical cytoskeleton; dendrite cytoplasm; voltage-gated potassium channel complex; basolateral plasma membrane; endoplasmic reticulum; postsynaptic density; dendritic spine; excitatory synapse; postsynaptic membrane; synaptic vesicle; extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; ionotropic glutamate receptor complex; synapse; cell junction

Molecular Function: P2Y1 nucleotide receptor binding; protein C-terminus binding; guanylate kinase activity; ionotropic glutamate receptor binding; protein binding; beta-1 adrenergic receptor binding; protein complex binding; acetylcholine receptor binding; D1 dopamine receptor binding; protein phosphatase binding; PDZ domain binding

Biological Process: regulation of long-term neuronal synaptic plasticity; axon guidance; nervous system development; synaptic vesicle maturation; social behavior; learning; signal transduction; positive regulation of synaptic transmission; establishment and/or maintenance of epithelial cell polarity; synaptic transmission; elevation of cytosolic calcium ion concentration; establishment of protein localization; protein complex assembly; neuromuscular process controlling balance; negative regulation of receptor internalization; nucleotide phosphorylation
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 Research Articles on DLG4    1. CAR and ASIC3 co-immunoprecipitate only when co-expressed with PSD-95.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DLG4 antibodyPathways associated with anti-DLG4 antibody
 Reference Product  PubMed Publications
 ERBB4 antibody  >3 publications with DLG4 and ERBB4
 CRIPT antibody  >2 publications with DLG4 and CRIPT
 GRIN2A antibody  >2 publications with DLG4 and GRIN2A
 GRIN1 antibody  >1 publications with DLG4 and GRIN1
 GRIN2B antibody  >1 publications with DLG4 and GRIN2B
 Products by Pathway  Pathway Diagram
 Activation Of Ca-permeable Kainate Receptor Pathway antibodies  Activation Of Ca-permeable Kainate Receptor Pathway Diagram
 Activation Of Kainate Receptors Upon Glutamate Binding Pathway antibodies  Activation Of Kainate Receptors Upon Glutamate Binding Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram
Diseases associated with anti-DLG4 antibodyOrgans/Tissues associated with anti-DLG4 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >29 publications with DLG4 and Nervous System Diseases
 Brain Diseases Antibodies  >28 publications with DLG4 and Brain Diseases
 Death Antibodies  >9 publications with DLG4 and Death
 Movement Disorders Antibodies  >6 publications with DLG4 and Movement Disorders
 Disease Models, Animal Antibodies  >6 publications with DLG4 and Disease Models, Animal
 Cognition Disorders Antibodies  >5 publications with DLG4 and Cognition Disorders
 Pain Antibodies  >4 publications with DLG4 and Pain
 Learning Disorders Antibodies  >3 publications with DLG4 and Learning Disorders
 Child Development Disorders, Pervasive Antibodies  >3 publications with DLG4 and Child Development Disorders, Pervasive
 Poisoning Antibodies  >2 publications with DLG4 and Poisoning
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >79 publications with DLG4 and Brain
 Muscle Antibodies  >7 publications with DLG4 and Muscle
 Kidney Antibodies  >5 publications with DLG4 and Kidney
 Embryonic Tissue Antibodies  >3 publications with DLG4 and Embryonic Tissue
 Eye Antibodies  >3 publications with DLG4 and Eye
 Skin Antibodies  >2 publications with DLG4 and Skin
 Lung Antibodies  >1 publications with DLG4 and Lung
 Testis Antibodies  >1 publications with DLG4 and Testis
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