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anti-PDCD1 antibody :: Mouse Programmed Cell Death 1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140297 anti-PDCD1 antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Programmed Cell Death 1 (PDCD1), Monoclonal Antibody

 Also Known As   

Mouse Anti Human Programmed Cell Death 1

 Product Synonym Names    PDCD1 Antibody; Programmed cell death protein 1, Mouse Anti Human; Programmed cell death protein 1; Protein PD-1; hPD-1; CD279; PDCD1; PD1; SLEB2
 Product Gene Name   

anti-PDCD1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109100
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 Clonality    Monoclonal
 Isotype    IgG2b heavy chain and kappa light chain
 Clone Number    P4F12AT
 Host    Mouse
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 Purity/Purification    PDCD1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
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 Immunogen    Anti-human PDCD1 mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PDCD1 amino acids 21-167 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-PDCD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PDCD1 antibody

   Introduction: PDCD1 is a cell surface membrane protein of the immunoglobulin superfamily. PDCD1 is expressed in pro-B-cells and is thought to have a role in their differentiation. In mice, expression of PDCD1 gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for the PDCD1 gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that the PDCD1 gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
 Product Categories/Family for anti-PDCD1 antibody    MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies
 Applications Tested/Suitable for anti-PDCD1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-PDCD1 antibody    PDCD1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.
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NCBI/Uniprot data below describe general gene information for PDCD1. It may not necessarily be applicable to this product.
 NCBI GI #    167857792
 NCBI GeneID    5133
 NCBI Accession #    NP_005009.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005018.2 [Other Products]
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 UniProt Secondary Accession #    O00517; Q8IX89 [Other Products]
 UniProt Related Accession #    Q15116 [Other Products]
 Molecular Weight    31,647 Da
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 NCBI Official Full Name    programmed cell death protein 1
 NCBI Official Synonym Full Names    programmed cell death 1
 NCBI Official Symbol    PDCD1 [Similar Products]
 NCBI Official Synonym Symbols   
PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
[Similar Products]
 NCBI Protein Information    programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2
 UniProt Protein Name    Programmed cell death protein 1
 UniProt Synonym Protein Names   
CD_antigen: CD279
 Protein Family    Programmed cell death
 UniProt Gene Name    PDCD1 [Similar Products]
 UniProt Synonym Gene Names    PD1; Protein PD-1; hPD-1 [Similar Products]
 UniProt Entry Name    PDCD1_HUMAN
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 NCBI Summary for PDCD1    This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PDCD1    PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse 'exhausted' T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells.

Protein type: Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; signal transducer activity

Biological Process: apoptosis; multicellular organismal development; T cell costimulation; signal transduction; humoral immune response

Disease: Systemic Lupus Erythematosus
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 Research Articles on PDCD1    1. These data strongly support testing of PD-1-blocking agents in combination with standard-of-care chemoradiotherapy for papillomavirus (HPV)-related oropharyngeal cancer .
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PDCD1 antibodyPathways associated with anti-PDCD1 antibody
 Reference Product  PubMed Publications
 CD4 antibody  >418 publications with PDCD1 and CD4
 CD274 antibody  >336 publications with PDCD1 and CD274
 PDCD1LG2 antibody  >99 publications with PDCD1 and PDCD1LG2
 PTPN6 antibody  >7 publications with PDCD1 and PTPN6
 PTPN11 antibody  >7 publications with PDCD1 and PTPN11
 HLA-DR4 antibody  >1 publications with PDCD1 and HLA-DR4
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
Diseases associated with anti-PDCD1 antibodyOrgans/Tissues associated with anti-PDCD1 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >147 publications with PDCD1 and Liver Diseases
 Inflammation Antibodies  >115 publications with PDCD1 and Inflammation
 Melanoma Antibodies  >79 publications with PDCD1 and Melanoma
 Necrosis Antibodies  >75 publications with PDCD1 and Necrosis
 Lupus Erythematosus, Systemic Antibodies  >72 publications with PDCD1 and Lupus Erythematosus, Systemic
 Lung Diseases Antibodies  >58 publications with PDCD1 and Lung Diseases
 Lung Neoplasms Antibodies  >38 publications with PDCD1 and Lung Neoplasms
 Adenocarcinoma Antibodies  >35 publications with PDCD1 and Adenocarcinoma
 Kidney Diseases Antibodies  >28 publications with PDCD1 and Kidney Diseases
 Liver Neoplasms Antibodies  >26 publications with PDCD1 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >945 publications with PDCD1 and Blood
 Kidney Antibodies  >36 publications with PDCD1 and Kidney
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