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anti-PCNA antibody :: Mouse anti-Human Proliferating Cell Nuclear Antigen (PCNA) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2034670 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $115 +1 FREE 8GB USB
0.05 mg  /  $150 +1 FREE 8GB USB
0.1 mg  /  $190 +1 FREE 8GB USB
0.2 mg  /  $245 +1 FREE 8GB USB
1 mg  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proliferating Cell Nuclear Antigen (PCNA), Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-Proliferating Cell Nuclear Antigen (PCNA) Monoclonal Antibody

 Product Synonym Names    Cyclin
 Product Gene Name   

anti-PCNA antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Proliferating Cell Nuclear Antigen (PCNA) (MBS2034670)
Biotin Conjugated Secondary Antibody: IgG (MBS2086030)
 Matching Pairs    Unconjugated Antibody: Proliferating Cell Nuclear Antigen (PCNA) (MBS2034670)
FITC Conjugated Secondary Antibody: IgG (MBS2086031)
 Matching Pairs    Unconjugated Antibody: Proliferating Cell Nuclear Antigen (PCNA) (MBS2034670)
Biotin Conjugated Secondary Antibody: IgG (MBS2086033)
 Matching Pairs    Unconjugated Antibody: Proliferating Cell Nuclear Antigen (PCNA) (MBS2034670)
FITC Conjugated Secondary Antibody: IgG (MBS2086034)
 Matching Pairs    Unconjugated Antibody: Proliferating Cell Nuclear Antigen (PCNA) (MBS2034670)
HRP Conjugated Secondary Antibody: IgG (MBS2086035)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M15796 mRNA
 3D Structure    ModBase 3D Structure for P12004
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 Clonality    Monoclonal
 Host    Mouse
 Species Reactivity    Human
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 Specificity    The antibody is a mouse monoclonal antibody raised against PCNA. It has been selected for its ability to recognize PCNA in immunohistochemical staining and western blotting.
 Purity/Purification    Protein A + Protein G affinity chromatography
 Form/Format    Liquid
 Concentration    500ug/ml (lot specific)
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-PCNA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-PCNA antibody    Control Antibody; Tumor immunity; Developmental science
 Applications Tested/Suitable for anti-PCNA antibody   

Western Blot (WB)

 Application Notes for anti-PCNA antibody    Loading Control of WB.
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 Western Blot (WB) of anti-PCNA antibody    (Figure. Western Blot; Sample: Recombinant PCNA, Human.)
anti-PCNA antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PCNA antibody    (DAB staining on IHC-P; Samples: Human Thyroid cancer Tissue)
anti-PCNA antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PCNA. It may not necessarily be applicable to this product.
 NCBI GI #    4505641
 NCBI GeneID    5111
 NCBI Accession #    NP_002583.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002592.2 [Other Products]
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 UniProt Primary Accession #    P12004 [Other Products]
 UniProt Secondary Accession #    B2R897; D3DW02 [Other Products]
 UniProt Related Accession #    P12004 [Other Products]
 Molecular Weight    28,769 Da
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 NCBI Official Full Name    proliferating cell nuclear antigen
 NCBI Official Synonym Full Names    proliferating cell nuclear antigen
 NCBI Official Symbol    PCNA [Similar Products]
 NCBI Official Synonym Symbols   
ATLD2
[Similar Products]
 NCBI Protein Information    proliferating cell nuclear antigen
 UniProt Protein Name    Proliferating cell nuclear antigen
 UniProt Synonym Protein Names   
Cyclin
 Protein Family    Proliferating cell nuclear antigen
 UniProt Gene Name    PCNA [Similar Products]
 UniProt Synonym Gene Names    PCNA [Similar Products]
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 NCBI Summary for PCNA    The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PCNA    PCNA: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Homotrimer. Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with EXO1, POLH, POLK, DNMT1, ERCC5, FEN1, CDC6 and POLDIP2. Interacts with APEX2; this interaction is triggered by reactive oxygen species and increased by misincorporation of uracil in nuclear DNA. Forms a ternary complex with DNTTIP2 and core histone. Interacts with KCTD10 and PPP1R15A. Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B; the interaction is direct. Interacts with HLTF and SHPRH. Interacts with NUDT15. Interaction is disrupted in response to UV irradiation and acetylation. Interacts with p21Cip1/p21(CIP1) and CDT1; interacts via their PIP-box which also recruits the DCX(DTL) complex. Interacts with DDX11. Interacts with EGFR; positively regulates PCNA. Interacts with C12orf48/PARI. Interacts with SMARCAD1. Belongs to the PCNA family.

Protein type: Cell cycle regulation; DNA replication

Chromosomal Location of Human Ortholog: 20p12.3

Cellular Component: centrosome; DNA replication factor C complex; extracellular exosome; nuclear body; nuclear chromosome, telomeric region; nuclear replication fork; nucleoplasm; nucleus; PCNA complex; replication fork

Molecular Function: chromatin binding; damaged DNA binding; dinucleotide insertion or deletion binding; DNA polymerase processivity factor activity; enzyme binding; estrogen receptor binding; histone acetyltransferase binding; identical protein binding; MutLalpha complex binding; protein binding; purine-specific mismatch base pair DNA N-glycosylase activity; receptor tyrosine kinase binding

Biological Process: bypass DNA synthesis; cell proliferation; cellular response to hydrogen peroxide; cellular response to UV; DNA damage response, detection of DNA damage; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA ligation; epithelial cell differentiation; error-free translesion synthesis; error-prone postreplication DNA repair; G1/S-specific transcription in mitotic cell cycle; heart development; leading strand elongation; mismatch repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; positive regulation of deoxyribonuclease activity; positive regulation of DNA repair; positive regulation of DNA replication; protein sumoylation; protein ubiquitination; replication fork processing; response to cadmium ion; response to dexamethasone; response to estradiol; response to L-glutamate; telomere maintenance; telomere maintenance via semi-conservative replication; transcription-coupled nucleotide-excision repair

Disease: Ataxia-telangiectasia-like Disorder 2
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 Research Articles on PCNA    1. The here presented evidence that the PCNA inner surface is highly regulated to control DNA damage resistance represents a new concept that offers new opportunities to develop tools to manipulate the DNA damage response in cancer treatment. [review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PCNA antibodyPathways associated with anti-PCNA antibody
 Reference Product  PubMed Publications
 CCND1 antibody  >797 publications with PCNA and CCND1
 CDKN1A antibody  >678 publications with PCNA and CDKN1A
 CDK2 antibody  >323 publications with PCNA and CDK2
 CCNB1 antibody  >150 publications with PCNA and CCNB1
 FEN1 antibody  >97 publications with PCNA and FEN1
 MSH2 antibody  >61 publications with PCNA and MSH2
 RPA1 antibody  >60 publications with PCNA and RPA1
 DNMT1 antibody  >56 publications with PCNA and DNMT1
 HUS1 antibody  >53 publications with PCNA and HUS1
 RFC1 antibody  >44 publications with PCNA and RFC1
 Products by Pathway  Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-PCNA antibodyOrgans/Tissues associated with anti-PCNA antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6355 publications with PCNA and Neoplasms
 Adenocarcinoma Antibodies  >1350 publications with PCNA and Adenocarcinoma
 Liver Diseases Antibodies  >996 publications with PCNA and Liver Diseases
 Hyperplasia Antibodies  >920 publications with PCNA and Hyperplasia
 Nervous System Diseases Antibodies  >837 publications with PCNA and Nervous System Diseases
 Drug Toxicity Antibodies  >804 publications with PCNA and Drug Toxicity
 Cardiovascular Diseases Antibodies  >756 publications with PCNA and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >751 publications with PCNA and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >725 publications with PCNA and Liver Neoplasms
 Necrosis Antibodies  >709 publications with PCNA and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2399 publications with PCNA and Blood
 Liver Antibodies  >1833 publications with PCNA and Liver
 Vascular Antibodies  >1830 publications with PCNA and Vascular
 Muscle Antibodies  >1564 publications with PCNA and Muscle
 Brain Antibodies  >1011 publications with PCNA and Brain
 Kidney Antibodies  >957 publications with PCNA and Kidney
 Lung Antibodies  >885 publications with PCNA and Lung
 Skin Antibodies  >803 publications with PCNA and Skin
 Bone Antibodies  >741 publications with PCNA and Bone
 Lymph Antibodies  >634 publications with PCNA and Lymph
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