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anti-KLK3 antibody :: Mouse anti-Human Prostate Specific Antigen (PSA), Total Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS312606 anti-KLK3 antibody
Unit / Price
1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Prostate Specific Antigen (PSA), Total (KLK3), Monoclonal Antibody

★Popular Item★
 Also Known As   

MAb to Human PSA, Total

 Product Synonym Names    Monoclonal Antibody to Human Prostate Specific Antigen (PSA), Total
 Product Gene Name   

anti-KLK3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (51358171..51364020). Location: 19q13.41
 OMIM    176820
 3D Structure    ModBase 3D Structure for P07288
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    B496M
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Prostate Specific Antigen (PSA), Total
Reacts with total PSA (free PSA and PSA complexed with ACT)
 Purity/Purification    Ion exchange chromatography
 Form/Format    Purified, Liquid
 Concentration    Lot specific (OD280nm) (lot specific)
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 Immunogen    Prostate Specific Antigen (PSA)
 Affinity Constant    Not determined
 Buffer    PBS
 Preservative    0.09% Sodium azide
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Short term (up to 15 days) store at 2 to 8 degree C. Long term store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-KLK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-KLK3 antibody    Monoclonal Antibodies for Cancer Research
 Applications Tested/Suitable for anti-KLK3 antibody   

EIA/ELISA

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NCBI/Uniprot data below describe general gene information for KLK3. It may not necessarily be applicable to this product.
 NCBI GI #    4502173
 NCBI GeneID    354
 NCBI Accession #    NP_001639.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001648.2 [Other Products]
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 UniProt Primary Accession #    P07288 [Other Products]
 UniProt Secondary Accession #    Q16272; Q86TG8 [Other Products]
 UniProt Related Accession #    P07288; Q15096; Q15098; Q546G3; Q6LDS3; Q8IXI4; Q8NCW4; Q8WTQ8; Q96A30 [Other Products]
 Molecular Weight    28,741 Da [Similar Products]
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 NCBI Official Full Name    prostate-specific antigen isoform 1 preproprotein
 NCBI Official Synonym Full Names    kallikrein-related peptidase 3
 NCBI Official Symbol    KLK3 [Similar Products]
 NCBI Official Synonym Symbols   
APS; PSA; hK3; KLK2A1
[Similar Products]
 NCBI Protein Information    prostate-specific antigen; seminin; P-30 antigen; kallikrein-3; semenogelase; gamma-seminoprotein; prostate specific antigen
 UniProt Protein Name    Prostate-specific antigen
 UniProt Synonym Protein Names   
Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase
 Protein Family    Prostate-specific antigen
 UniProt Gene Name    KLK3 [Similar Products]
 UniProt Synonym Gene Names    APS [Similar Products]
 UniProt Entry Name    KLK3_HUMAN
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 NCBI Summary for KLK3    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq]
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 UniProt Comments for KLK3    Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Catalytic activity: Preferential cleavage: -Tyr-|-Xaa-.

Enzyme regulation: Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Ref.18

Subcellular location: Secreted.

Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.

Sequence caution: The sequence AAD14185.1 differs from that shown. Reason: Erroneous initiation.
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 Research Articles on KLK3    1. Both Chun's nomogram and the PCPT calculator, by incorporating PCA3, can assist in the decision to biopsy by assignment of an individual risk of prostate cancer, specifically in the PSA levels <10 ng/ml.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KLK3 antibodyPathways associated with anti-KLK3 antibody
 Reference Product  PubMed Publications
 SEMG2 antibody  >1 publications with KLK3 and SEMG2
 SEMG1 antibody  >1 publications with KLK3 and SEMG1
 CTNNB1 antibody  >1 publications with KLK3 and CTNNB1
 Products by Pathway  Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Activity By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
Diseases associated with anti-KLK3 antibodyOrgans/Tissues associated with anti-KLK3 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >63 publications with KLK3 and Neoplasms
 Male Urogenital Diseases Antibodies  >51 publications with KLK3 and Male Urogenital Diseases
 Urogenital Neoplasms Antibodies  >48 publications with KLK3 and Urogenital Neoplasms
 Prostatic Neoplasms Antibodies  >48 publications with KLK3 and Prostatic Neoplasms
 Carcinoma Antibodies  >13 publications with KLK3 and Carcinoma
 Breast Neoplasms Antibodies  >11 publications with KLK3 and Breast Neoplasms
 Adenocarcinoma Antibodies  >9 publications with KLK3 and Adenocarcinoma
 Female Urogenital Diseases Antibodies  >8 publications with KLK3 and Female Urogenital Diseases
 Neoplasms, Hormone-Dependent Antibodies  >7 publications with KLK3 and Neoplasms, Hormone-Dependent
 Urologic Diseases Antibodies  >6 publications with KLK3 and Urologic Diseases
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >83 publications with KLK3 and Prostate
 Salivary Gland Antibodies  >4 publications with KLK3 and Salivary Gland
 Brain Antibodies  >3 publications with KLK3 and Brain
 Muscle Antibodies  >2 publications with KLK3 and Muscle
 Bone Antibodies  >2 publications with KLK3 and Bone
 Adrenal Gland Antibodies  >1 publications with KLK3 and Adrenal Gland
 Nerve Antibodies  >1 publications with KLK3 and Nerve
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