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anti-PPM1D antibody :: Mouse anti-Human Protein Phosphatase 1D Magnesium-dependent, delta Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS603166 anti-PPM1D antibody
Unit / Price
0.05 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein Phosphatase 1D Magnesium-dependent, delta (PPM1D), Monoclonal Antibody

 Also Known As   

Protein Phosphatase 1D Magnesium-dependent, delta (PPM1D, PP2C-delta)

 Product Synonym Names    Anti -Protein Phosphatase 1D Magnesium-dependent, delta (PPM1D, PP2C-delta)
 Product Gene Name   

anti-PPM1D antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (58677554..58742036). Location: 17q23.2
 OMIM    605100
 3D Structure    ModBase 3D Structure for O15297
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    8J139
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human Protein Phosphatase 1D Magnesium-dependent, delta.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 1% BSA, 0.05% sodium azide.
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 Immunogen    Partial sequence of recombinant full-length protein to human Protein Phosphatase 1D Magnesium-dependent, delta.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-PPM1D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PPM1D antibody

   PPM1D is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. Expression of this PPM1D gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. The PPM1D gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
 Product Categories/Family for anti-PPM1D antibody    Antibodies; Abs to Enzymes, Phosphatase
 Applications Tested/Suitable for anti-PPM1D antibody   

Western Blot (WB), Gel Shift Assay (GS/EMSA)

 Application Notes for anti-PPM1D antibody    Suitable for use in Dot Blot and Western Blot.
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NCBI/Uniprot data below describe general gene information for PPM1D. It may not necessarily be applicable to this product.
 NCBI GI #    4505997
 NCBI GeneID    8493
 NCBI Accession #    NP_003611.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003620.3 [Other Products]
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 UniProt Primary Accession #    O15297 [Other Products]
 UniProt Secondary Accession #    Q53XP4 [Other Products]
 UniProt Related Accession #    O15297; Q6P991; Q8IVR6; Q8NEA7 [Other Products]
 Molecular Weight    66,675 Da [Similar Products]
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 NCBI Official Full Name    protein phosphatase 1D
 NCBI Official Synonym Full Names    protein phosphatase, Mg2+/Mn2+ dependent, 1D
 NCBI Official Symbol    PPM1D [Similar Products]
 NCBI Official Synonym Symbols   
WIP1; PP2C-DELTA
[Similar Products]
 NCBI Protein Information    protein phosphatase 1D; protein phosphatase Wip1; wild-type p53-induced phosphatase 1; protein phosphatase 2C delta isoform; protein phosphatase magnesium-dependent 1 delta; protein phosphatase 1D magnesium-dependent, delta isoform
 UniProt Protein Name    Protein phosphatase 1D
 UniProt Synonym Protein Names   
Protein phosphatase 2C isoform delta; PP2C-delta; Protein phosphatase magnesium-dependent 1 delta; p53-induced protein phosphatase 1
 Protein Family    Protein phosphatase
 UniProt Gene Name    PPM1D [Similar Products]
 UniProt Synonym Gene Names    WIP1 [Similar Products]
 UniProt Entry Name    PPM1D_HUMAN
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 NCBI Summary for PPM1D    The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq]
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 UniProt Comments for PPM1D    PPM1D: a magnesium-dependent Ser/Thr phosphatase. A p53-induced phosphatase that interacts with the nuclear isoform of uracil DNA glycosylase, UNG2, and suppresses base excision repair. Might contribute to growth inhibitory pathways activated in response to DNA damage in a p53-dependent manner.

Protein type: Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16; Nuclear receptor co-regulator; Cell cycle regulation; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: nucleus

Molecular Function: protein binding; metal ion binding; protein serine/threonine phosphatase activity

Biological Process: negative regulation of cell proliferation; response to radiation; response to bacterium; G2/M transition of mitotic cell cycle; protein amino acid dephosphorylation

Disease: Breast Cancer
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 Research Articles on PPM1D    1. the increased expression of Wip1 in cancer epithelial cells has significant value for tumor progression and the clinical prognosis of patients with primary lung adenocarcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PPM1D antibodyDiseases associated with anti-PPM1D antibody
 Products by Pathway  Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >35 publications with PPM1D and Neoplasms
 Breast Neoplasms Antibodies  >17 publications with PPM1D and Breast Neoplasms
 Carcinoma Antibodies  >10 publications with PPM1D and Carcinoma
 Adenocarcinoma Antibodies  >9 publications with PPM1D and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >6 publications with PPM1D and Cell Transformation, Neoplastic
 Chromosome Aberrations Antibodies  >6 publications with PPM1D and Chromosome Aberrations
 Glioma Antibodies  >4 publications with PPM1D and Glioma
 Neuroectodermal Tumors Antibodies  >4 publications with PPM1D and Neuroectodermal Tumors
 Medulloblastoma Antibodies  >3 publications with PPM1D and Medulloblastoma
 Pancreatic Neoplasms Antibodies  >2 publications with PPM1D and Pancreatic Neoplasms
Organs/Tissues associated with anti-PPM1D antibody
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >2 publications with PPM1D and Lymph Node
 Blood Antibodies  >2 publications with PPM1D and Blood
 Brain Antibodies  >2 publications with PPM1D and Brain
 Prostate Antibodies  >1 publications with PPM1D and Prostate
 Liver Antibodies  >1 publications with PPM1D and Liver
 Bone Antibodies  >1 publications with PPM1D and Bone
 Spleen Antibodies  >1 publications with PPM1D and Spleen
 Stomach Antibodies  >1 publications with PPM1D and Stomach
 Embryonic Tissue Antibodies  >1 publications with PPM1D and Embryonic Tissue
 Testis Antibodies  >1 publications with PPM1D and Testis
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