P35813
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
protein phosphatase 2C alpha
NCBI Official Synonym Full Names
protein phosphatase, Mg2+/Mn2+ dependent, 1A
NCBI Official Synonym Symbols
PP2CA; MGC9201; FLJ42306; PP2Calpha; PP2C-ALPHA [Similar Products]
NCBI Protein Information
protein phosphatase 1A; OTTHUMP00000179040; OTTHUMP00000179041; OTTHUMP00000232007; OTTHUMP00000232008; phosphatase 2C alpha; protein phosphatase IA; protein phosphatase 2C alpha isoform; protein phosphatase 2C isoform alpha; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
UniProt Protein Name
Protein phosphatase 1A
UniProt Synonym Protein Names
Protein phosphatase 2C isoform alpha; PP2C-alpha; Protein phosphatase IA
UniProt Synonym Gene Names
UniProt Entry Name
PPM1A_HUMAN
NCBI Summary for PPM1A
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]
UniProt Comments for PPM1A
PPPM1A: a Ser/Thr protein phosphatase of the PP2C family. Inhibits the activation of p38 and JNK kinase cascades induced by environmental stresses. Can also dephosphorylate cyclin-dependent kinases and may play a role in cell cycle control. Overexpression of this phosphatase activates the expression of p53, leading to G2/M cell cycle arrest and apoptosis.
Protein type: Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14q23.1
Cellular Component: nucleoplasm; neuron projection; membrane; voltage-gated calcium channel complex; nucleus; cytosol
Molecular Function: protein C-terminus binding; protein binding; signal transducer activity; calmodulin-dependent protein phosphatase activity; manganese ion binding; magnesium ion binding; protein serine/threonine phosphatase activity
Biological Process: N-terminal protein myristoylation; transcription initiation from RNA polymerase II promoter; Wnt receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of NF-kappaB import into nucleus; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation; dephosphorylation; transforming growth factor beta receptor signaling pathway; insulin receptor signaling pathway; gene expression; negative regulation of transforming growth factor beta receptor signaling pathway; cell cycle arrest; positive regulation of Wnt receptor signaling pathway
Research Articles on PPM1A
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Products associated with anti-PPM1A antibody
Pathways associated with anti-PPM1A antibody
Diseases associated with anti-PPM1A antibody
Disease Name |
Pubmed Publications |
Neoplasms Antibodies |
>3 publications with PPM1A and Neoplasms |
Fibrosis Antibodies |
>1 publications with PPM1A and Fibrosis |
Female Urogenital Diseases Antibodies |
>1 publications with PPM1A and Female Urogenital Diseases |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies |
>1 publications with PPM1A and Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
Diabetic Nephropathies Antibodies |
>1 publications with PPM1A and Diabetic Nephropathies |
Leukemia, Myeloid Antibodies |
>1 publications with PPM1A and Leukemia, Myeloid |
Carcinoma, Hepatocellular Antibodies |
>1 publications with PPM1A and Carcinoma, Hepatocellular |
Adenocarcinoma Antibodies |
>1 publications with PPM1A and Adenocarcinoma |
Liver Diseases Antibodies |
>1 publications with PPM1A and Liver Diseases |
Kidney Diseases Antibodies |
>1 publications with PPM1A and Kidney Diseases |
Organs/Tissues associated with anti-PPM1A antibody
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