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anti-TGM2 antibody :: Mouse Protein-glutamine gamma-glutamyltransferase 2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1493349
Unit / Price
0.05 mg  /  $185 +1 FREE 8GB USB
0.1 mg  /  $265 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein-glutamine gamma-glutamyltransferase 2 (TGM2), Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse anti Human Protein-glutamine gamma-glutamyltransferase 2(TGM2) monoclonal Antibody

 Product Synonym Names    Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C
 Product Gene Name   

anti-TGM2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    190196
 3D Structure    ModBase 3D Structure for P21980
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 Clonality    Monoclonal
 Host    Mouse
 Species Reactivity    Human. Other species are not tested. Please decide the specificity by homology
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 Specificity    Specific for TGM2 native and denatured forms
 Purity/Purification    >95%, Protein G Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant Human Protein-glutamine gamma-glutamyltransferase 2(TGM2)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48370 / sc-48387 / sc-73612
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TGM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TGM2 antibody

   Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
 Applications Tested/Suitable for anti-TGM2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Immunohistochemistry (IHC) of anti-TGM2 antibody    Immunohistochemical of paraffin-embedded Human placenta tissue using MBS1493349 at dilution of 1:200.
anti-TGM2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-TGM2 antibody    Immunohistochemical of paraffin-embedded Human Breast tissue using MBS1493349 at dilution of 1:200.
anti-TGM2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-TGM2 antibody    All lanes: Mouse anti-TGM2 Monoclonal antibody at 1ug/ml
Lane 1: A549 whole cell lysate
Secondary Goat polyclonal to Mouse IgG at 1/5000 dilution
Predicted band size:77kd
Observed band size:77,62,39KD
Additional bands at:30kd

anti-TGM2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TGM2. It may not necessarily be applicable to this product.
 NCBI GI #    39777597
 NCBI GeneID    7052
 NCBI Accession #    NP_004604.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004613.2 [Other Products]
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 UniProt Primary Accession #    P21980 [Other Products]
 UniProt Secondary Accession #    Q16436; Q6B838; Q9BTN7; Q9UH35; E1P5V9 [Other Products]
 UniProt Related Accession #    P21980 [Other Products]
 Molecular Weight    38,671 Da
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 NCBI Official Full Name    protein-glutamine gamma-glutamyltransferase 2 isoform a
 NCBI Official Synonym Full Names    transglutaminase 2
 NCBI Official Symbol    TGM2 [Similar Products]
 NCBI Official Synonym Symbols   
TG2; TGC; GNAH; HEL-S-45; G-ALPHA-h
[Similar Products]
 NCBI Protein Information    protein-glutamine gamma-glutamyltransferase 2
 UniProt Protein Name    Protein-glutamine gamma-glutamyltransferase 2
 UniProt Synonym Protein Names   
Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2
 Protein Family    Protein-glutamine gamma-glutamyltransferase
 UniProt Gene Name    TGM2 [Similar Products]
 UniProt Synonym Gene Names    TG(C); TGC; TGase C; TGase H; TGase-2 [Similar Products]
 UniProt Entry Name    TGM2_HUMAN
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 NCBI Summary for TGM2    Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TGM2    TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described.

Protein type: EC 2.3.2.13; Transferase

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: cytosol; endoplasmic reticulum; focal adhesion; intrinsic to plasma membrane; mitochondrion

Molecular Function: metal ion binding; protein binding; protein-glutamine gamma-glutamyltransferase activity

Biological Process: apoptotic cell clearance; elevation of mitochondrial calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); peptide cross-linking; positive regulation of apoptosis; positive regulation of cell adhesion; reduction of endoplasmic reticulum calcium ion concentration
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 Research Articles on TGM2    1. Data indicate Gln34, Gln42, Gln193 and Gln248 as the major transglutaminase 2 (TG2 reactive glutamines in osteopontin (OPN).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TGM2 antibodyPathways associated with anti-TGM2 antibody
 Reference Product  PubMed Publications
 ATM antibody  >2 publications with TGM2 and ATM
 FN1 antibody  >2 publications with TGM2 and FN1
 HTT antibody  >1 publications with TGM2 and HTT
 ITGB1 antibody  >1 publications with TGM2 and ITGB1
 Products by Pathway  Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Thromboxane A2 Receptor Signaling Pathway antibodies  Thromboxane A2 Receptor Signaling Pathway Diagram
Diseases associated with anti-TGM2 antibodyOrgans/Tissues associated with anti-TGM2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >10 publications with TGM2 and Inflammation
 Necrosis Antibodies  >6 publications with TGM2 and Necrosis
 Disease Models, Animal Antibodies  >6 publications with TGM2 and Disease Models, Animal
 Lung Neoplasms Antibodies  >6 publications with TGM2 and Lung Neoplasms
 Breast Neoplasms Antibodies  >6 publications with TGM2 and Breast Neoplasms
 Fibrosis Antibodies  >5 publications with TGM2 and Fibrosis
 Brain Neoplasms Antibodies  >5 publications with TGM2 and Brain Neoplasms
 Cardiovascular Diseases Antibodies  >5 publications with TGM2 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with TGM2 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >4 publications with TGM2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >11 publications with TGM2 and Lung
 Blood Antibodies  >11 publications with TGM2 and Blood
 Liver Antibodies  >10 publications with TGM2 and Liver
 Brain Antibodies  >10 publications with TGM2 and Brain
 Bone Antibodies  >9 publications with TGM2 and Bone
 Eye Antibodies  >8 publications with TGM2 and Eye
 Skin Antibodies  >7 publications with TGM2 and Skin
 Vascular Antibodies  >6 publications with TGM2 and Vascular
 Connective Tissue Antibodies  >5 publications with TGM2 and Connective Tissue
 Bone Marrow Antibodies  >5 publications with TGM2 and Bone Marrow
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