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anti-F2 antibody :: Mouse anti-Human Prothrombin (Calcium dependant) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS520489 anti-F2 antibody
Unit / Price
0.2 mg  /  $395 +1 FREE 8GB USB
 
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 Product Name   

Prothrombin (Calcium dependant) (F2), Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-Human Prothrombin (Calcium dependant), Purified, (clone: Ca-Pro 20) (Mouse IgG1)

 Product Synonym Names    Prothrombin (Calcium dependant), Purified, (clone: Ca-Pro 20) (Mouse IgG1); Calcium-Dependent Anti-Human Prothrombin (CaPro-20)
 Product Gene Name   

anti-F2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (46740743..46761056). Location: 11p11
 OMIM    176930
 3D Structure    ModBase 3D Structure for P00734
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 Clonality    Monoclonal
 Isotype    Mouse IgG1
 Clone Number    CaPro-20
 Host    Mouse
 Species Reactivity    Human
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 Specificity    This antibody is specific for Human Prothrombin (CaPro-20)
 Form/Format    Purified
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen    Human Prothrombin (CaPro-20) purified from plasma.
 Presentation    Purified IgG buffered in PBS and 0.02% NaN3. (Purified from ascitic fluid via Protein G Chromatography).
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 Preparation and Storage    Store at +4 degree C. For long term storage, aliquot and feeze unused portion at -20 degree C in volumes appropriate for single use. Avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-F2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-F2 antibody

   Prothrombin is a 72 kDa blood clotting glycoprotein formed by and stored in the Liver. Prothrombin is present in the blood plasma and is converted to the key blood clotting agent thrombin, when blood vessels are damaged. Factor VII, another important haemostasis protein can be converted to VIIa by Factor IXa or thrombin.
 Applications Tested/Suitable for anti-F2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-F2 antibody    This antibody is suitable for use in ELISA and Western Blot.
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NCBI/Uniprot data below describe general gene information for F2. It may not necessarily be applicable to this product.
 NCBI GI #    261695
 NCBI GeneID    2147
 NCBI Accession #    AAB24476.1 [Other Products]
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 UniProt Primary Accession #    P00734 [Other Products]
 UniProt Secondary Accession #    Q4QZ40; Q53H04; Q53H06; Q7Z7P3; Q9UCA1; B2R7F7; B4E1A7 [Other Products]
 UniProt Related Accession #    P00734 [Other Products]
 Molecular Weight    70,037 Da [Similar Products]
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 NCBI Official Full Name    prothrombin
 NCBI Official Synonym Full Names    coagulation factor II (thrombin)
 NCBI Official Symbol    F2 [Similar Products]
 NCBI Official Synonym Symbols   
PT; THPH1; RPRGL2
[Similar Products]
 NCBI Protein Information    prothrombin; serine protease; prothrombin B-chain; prepro-coagulation factor II
 UniProt Protein Name    Prothrombin
 UniProt Synonym Protein Names   
Coagulation factor II
 Protein Family    Prothrombin
 UniProt Gene Name    F2 [Similar Products]
 UniProt Entry Name    THRB_HUMAN
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 NCBI Summary for F2    Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for F2    Function: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Ref.13

Catalytic activity: Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

Enzyme regulation: Inhibited by SERPINA5. Ref.11

Subunit structure: Heterodimer (named alpha-thrombin) of a light and a heavy chain; disulfide-linked. Forms a heterodimer with SERPINA5.

Subcellular location: Secreted › extracellular space.

Tissue specificity: Expressed by the liver and secreted in plasma.

Post-translational modification: The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin.N-glycosylated. N-glycan heterogeneity at Asn-121: Hex3HexNAc3 (minor), Hex4HexNAc3 (minor) and Hex5HexNAc4 (major). At Asn-143: Hex4HexNAc3 (minor) and Hex5HexNAc4 (major). Ref.22

Involvement in disease: Factor II deficiency (FA2D) [MIM:613679]: A very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2 Ref.35 Ref.36 Ref.37 Ref.38 Ref.39 Ref.40 Ref.41 Ref.42 Ref.43 Ref.44 Ref.45Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.15Thrombophilia due to thrombin defect (THPH1) [MIM:188050]: A multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation.Note: The disease is caused by mutations affecting the gene represented in this entry. A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis.Pregnancy loss, recurrent, 2 (RPRGL2) [MIM:614390]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.14

Pharmaceutical use: The peptide TP508 also known as Chrysalin (Orthologic) could be used to accelerate repair of both soft and hard tissues.

Miscellaneous: Prothrombin is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin and factors Va and Xa in Ca-dependent interactions; factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin.It is not known whether 1 or 2 smaller activation peptides, with additional cleavage after Arg-314, are released in natural blood clotting.Thrombin can itself cleave the N-terminal fragment (fragment 1) of the prothrombin, prior to its activation by factor Xa.The cleavage after Arg-198, observed in vitro, does not occur in plasma.

Sequence similarities: Belongs to the peptidase S1 family.Contains 1 Gla (gamma-carboxy-glutamate) domain.Contains 2 kringle domains.Contains 1 peptidase S1 domain.
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 Research Articles on F2    1. ERM proteins play important differential roles in the thrombin-induced modulation of EC permeability, with moesin promoting barrier dysfunction and radixin opposing it.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-F2 antibodyDiseases associated with anti-F2 antibody
 Products by Pathway  Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1048 publications with F2 and Nervous System Diseases
 Liver Diseases Antibodies  >726 publications with F2 and Liver Diseases
 Neoplasms Antibodies  >689 publications with F2 and Neoplasms
 Hypertension Antibodies  >669 publications with F2 and Hypertension
 Inflammation Antibodies  >542 publications with F2 and Inflammation
 Liver Cirrhosis Antibodies  >487 publications with F2 and Liver Cirrhosis
 Brain Diseases Antibodies  >464 publications with F2 and Brain Diseases
 Heart Diseases Antibodies  >300 publications with F2 and Heart Diseases
 Kidney Diseases Antibodies  >258 publications with F2 and Kidney Diseases
 Necrosis Antibodies  >228 publications with F2 and Necrosis
Organs/Tissues associated with anti-F2 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1320 publications with F2 and Liver
 Uterus Antibodies  >958 publications with F2 and Uterus
 Kidney Antibodies  >723 publications with F2 and Kidney
 Heart Antibodies  >682 publications with F2 and Heart
 Embryonic Tissue Antibodies  >365 publications with F2 and Embryonic Tissue
 Connective Tissue Antibodies  >255 publications with F2 and Connective Tissue
 Spleen Antibodies  >234 publications with F2 and Spleen
 Bone Marrow Antibodies  >105 publications with F2 and Bone Marrow
 Mammary Gland Antibodies  >32 publications with F2 and Mammary Gland
 Uncharacterized Tissue Antibodies  >2 publications with F2 and Uncharacterized Tissue
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