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Add To Compare List Mouse anti-Mouse Qa-1b Monoclonal Antibody Catalog # MBS6007408 Unit / Price 0.1 mg / $735 +1 FREE 8GB USB 5x0.1 mg / $3,125 +3 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Qa-1b, Monoclonal Antibody Popular Item Full Product Name Qa-1b (H2 T23, H2 Class I Histocompatibility Antigen D37 alpha Chain, H2 Q1, Histocompatibility 2 T Region Locus 23, MHC Class I Antigen Qa1, MHC ClassIb Qa1, OTTMUSP00000015895, Qa1) Product Synonym Names Anti -Qa-1b (H2 T23, H2 Class I Histocompatibility Antigen D37 alpha Chain, H2 Q1, Histocompatibility 2 T Region Locus 23, MHC Class I Antigen Qa1, MHC ClassIb Qa1, OTTMUSP00000015895, Qa1) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Clonality Monoclonal Isotype IgG1,k Clone Number 11E331 Host Mouse Species Reactivity Mouse Specificity Recognizes mouse Qa-1b. Species Crossreactivity: human. Purity/Purification Affinity PurifiedPurified by Protein G affinity chromatography. Form/Format Supplied as a liquid in PBS, 0.05% sodium azide. Concentration 1mg/mL (lot specific) Immunogen Synthetic peptide corresponding to the alpha-2 domain of Qa-1b. Hybridoma P3X63-Ag8.653 myeloma cells with spleen cells from Balb/c mice. Preparation and Storage May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Other Notes Small volumes of anti-Qa-1b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-Qa-1b antibody Qa-1, a nonclassical class I histocompatibility molecule encoded by the T23 gene in the T region expressed in mice, predominantly assembles with a single nonameric peptide, Qdm, derived from the signal sequence of certain class Ia molecules. The Qa-1/Qdm complex serves as a ligand for CD94/NKG2 natural killer (NK) receptor(s) express on a major fraction of NK cells and CD8+ immuno-suppressive regulatory T cells. Qa-1, expressing on immuno-regulatory B cells and other antigen presenting cells, serves for antigen-presentation to immuno-regulatory CD8+ T. Moreover, Qa-1 serves for MHC restrictive function because, unlike conventional MHC molecules, it transiently expresses on activated CD4+ T cells. Recently it has also been shown that Qa-1 is ubiquitously expressed in the immune-privileged anterior chamber of the eye. Additionally, it has been suggested that TCR specific, Qa-1-restricted regulatory CD8+ T cells selectively down regulate antigen-activated T cells expressing TCRs of certain affinities. These regulatory CD8+ T cells may control the peripheral TCR repertoire during the course of immune responses to both self and foreign antigens. The 6A8.6F10.1A6 mAb can be used for flow cytometric assay to detect Qa-1b on immuno-regulatory antigen presenting cells and activated splenic T cells on Qa-1b expressing mice (e.g. BALB/c, C57BL/6) and it can also be used for functional assays to block target cell recognition by CTLs specific for Qa-1 restricted antigen presentation and other functional study where Qa-1b associated immuno-regulation may work. Product Categories/Family for anti-Qa-1b antibody Antibodies; Abs to HLA Applications Tested/Suitable for anti-Qa-1b antibody Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC), Neutralization Application Notes for anti-Qa-1b antibody Suitable for use in Western Blot, Immunoprecipitation, Neutralization and Flow Cytometry.Flow Cytometry: 1:10-1:1000Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher. Western Blot (WB) of anti-Qa-1b antibody Western Blot analysis of Qa-1b in mouse thymus tissue lysate using MBS6007408 at 2ug/ml. Flow Cytometry (FC/FACS) of anti-Qa-1b antibody Flow Cytometric analysis of Qa-1b in 72 hour ConA-stimulated Balb/c mouse splenocytes using A) isotype control and B) MBS6007408 (with an anti-mouse IgG1-PE secondary) at 0.25ug/10e6 cells. A shift is seen in the entire population of cells. Flow Cytometry (FC/FACS) of anti-Qa-1b antibody Flow Cytometric analysis of Qa-1b in unstimulated Balb/c mouse splenocytes using A) isotype control and B) MBS6007408 (with an anti-mouse IgG1-PE secondary) at 0.25ug/10e6 cells. A shift is seen in only a small percentage of cells. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP