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anti-RRAS antibody :: Mouse anti-Human R-ras / P23 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245679
Unit / Price
0.05 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

R-ras / P23 (RRAS), Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 6A8] (IgG2b,k) to Human R-ras / P23

 Product Synonym Names    Anti-R-ras / P23 Antibody (clone 6A8) IHC-plus; Oncogene RRAS; R-ras; Ras-related protein R-Ras2; p23; Ras-related protein R-Ras; Human R-ras; P23
 Product Gene Name   

anti-RRAS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    165090
 3D Structure    ModBase 3D Structure for P10301
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 Clonality    Monoclonal
 Isotype    IgG2b,k
 Clone Number    6A8
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Ammonium sulfate precipitation
 Form/Format    HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
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 Target Species    Human
 Immunogen Description    Recombinant human protein purified from E Coli (His-R-Ras).
 Immunogen Type    Recombinant protein
 Immunogen    R-ras / P23 antibody was raised against recombinant human protein purified from E Coli (His-R-Ras).
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-RRAS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-RRAS antibody    Family: Ras GTPase superfamily IPR001806
 Applications Tested/Suitable for anti-RRAS antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-RRAS antibody    IHC-P (1:400), WB (1:2000)
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 Immunohistochemistry (IHC) of anti-RRAS antibody    Anti-RRAS antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:400.
anti-RRAS antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-RRAS antibody     
anti-RRAS antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for RRAS. It may not necessarily be applicable to this product.
 NCBI GI #    5454028
 NCBI GeneID    6237
 NCBI Accession #    NP_006261.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006270.3 [Other Products]
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 UniProt Primary Accession #    P10301 [Other Products]
 UniProt Secondary Accession #    Q6FH12 [Other Products]
 UniProt Related Accession #    P10301 [Other Products]
 Molecular Weight    23,480 Da
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 NCBI Official Full Name    ras-related protein R-Ras
 NCBI Official Synonym Full Names    related RAS viral (r-ras) oncogene homolog
 NCBI Official Symbol    RRAS [Similar Products]
 NCBI Protein Information    ras-related protein R-Ras; p23; Oncogene RRAS
 UniProt Protein Name    Ras-related protein R-Ras
 UniProt Synonym Protein Names   
p23
 Protein Family    Ras-related protein
 UniProt Gene Name    RRAS [Similar Products]
 UniProt Entry Name    RRAS_HUMAN
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 NCBI Summary for RRAS    The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]
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 UniProt Comments for RRAS    RRas: a small G protein of the Ras family. Promotes focal adhesion formation by signaling to FAK and p130(Cas). Promotes tumor growth of cervical epithelial cells and increases their migration potential over collagen through a pathway that involves PI 3-K.

Protein type: G protein, monomeric; G protein; Motility/polarity/chemotaxis; G protein, monomeric, Ras

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: focal adhesion; plasma membrane

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; protein complex binding

Biological Process: axon guidance; synaptic transmission; positive regulation of angiogenesis; metabolic process; Ras protein signal transduction; leukocyte differentiation; regulation of protein kinase B signaling cascade; negative regulation of cell migration
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 Research Articles on RRAS    1. Contradicting the positive association reported in previous studies, our results indicate that R-Ras activation may negatively regulate the transformation of breast epithelial cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RRAS antibodyPathways associated with anti-RRAS antibody
 Reference Product  PubMed Publications
 SRC antibody  >5 publications with RRAS and SRC
 SEMA4D antibody  >3 publications with RRAS and SEMA4D
 RAF1 antibody  >3 publications with RRAS and RAF1
 EPHB2 antibody  >1 publications with RRAS and EPHB2
 Products by Pathway  Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPHB Forward Signaling Pathway antibodies  EPHB Forward Signaling Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
Diseases associated with anti-RRAS antibodyOrgans/Tissues associated with anti-RRAS antibody
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >11 publications with RRAS and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >7 publications with RRAS and Nervous System Diseases
 Breast Neoplasms Antibodies  >6 publications with RRAS and Breast Neoplasms
 Brain Diseases Antibodies  >6 publications with RRAS and Brain Diseases
 Inflammation Antibodies  >5 publications with RRAS and Inflammation
 Neoplasm Metastasis Antibodies  >4 publications with RRAS and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >3 publications with RRAS and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >2 publications with RRAS and Liver Neoplasms
 Uterine Cervical Neoplasms Antibodies  >2 publications with RRAS and Uterine Cervical Neoplasms
 Fibrosis Antibodies  >2 publications with RRAS and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with RRAS and Brain
 Muscle Antibodies  >9 publications with RRAS and Muscle
 Testis Antibodies  >7 publications with RRAS and Testis
 Bone Antibodies  >7 publications with RRAS and Bone
 Heart Antibodies  >6 publications with RRAS and Heart
 Connective Tissue Antibodies  >4 publications with RRAS and Connective Tissue
 Embryonic Tissue Antibodies  >4 publications with RRAS and Embryonic Tissue
 Prostate Antibodies  >4 publications with RRAS and Prostate
 Lymph Antibodies  >3 publications with RRAS and Lymph
 Kidney Antibodies  >3 publications with RRAS and Kidney
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