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anti-RSPO1 antibody :: Mouse anti-Human R spondin1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS830411
Western Blot
Unit / Price
0.1 mL  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

R spondin1 (RSPO1), Monoclonal Antibody

 Also Known As   

R spondin1 antibody

 Product Synonym Names    Monoclonal R spondin1; Anti-R spondin1; R spondin-1; R spondin 1; Rspondin1; RSPO1; CRISTIN3; R spondin1; R-spondin1; FLJ40906
 Product Gene Name   

anti-RSPO1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609595
 3D Structure    ModBase 3D Structure for Q2MKA7
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    7A6
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    R spondin1 is a member of the R-spondin family and a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. It is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
 Immunogen    R spondin1 antibody was raised in Mouse using a purified recombinant fragment of RSPO1 expressed in E Coli as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-RSPO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RSPO1 antibody

   Mouse monoclonal R spondin1 antibody
 Product Categories/Family for anti-RSPO1 antibody    Signal Transduction
 Applications Tested/Suitable for anti-RSPO1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-RSPO1 antibody    ELISA: 1:10,000
WB: 1:500-1:2000
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 Western Blot of anti-RSPO1 antibody    Western Blot analysis using R spondin1 antibody
Western Blot showing R-spondin1 antibody used against recombinant R-spondin1 protein (1) and R-spondin1 (aa21-263)-hIgGFc transfected HEK293 cell lysate (2).
anti-RSPO1 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for RSPO1. It may not necessarily be applicable to this product.
 NCBI GI #    339276103
 NCBI GeneID    284654
 NCBI Accession #    NP_001229839.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001242910.1 [Other Products]
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 UniProt Primary Accession #    Q2MKA7 [Other Products]
 UniProt Secondary Accession #    Q0H8S6; Q14C72; Q5T0F2; Q8N7L5; A2A420 [Other Products]
 UniProt Related Accession #    Q2MKA7 [Other Products]
 Molecular Weight    21,775 Da [Similar Products]
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 NCBI Official Full Name    R-spondin-1 isoform 3
 NCBI Official Synonym Full Names    R-spondin 1
 NCBI Official Symbol    RSPO1 [Similar Products]
 NCBI Official Synonym Symbols   
RSPO; CRISTIN3
[Similar Products]
 NCBI Protein Information    R-spondin-1
 UniProt Protein Name    R-spondin-1
 UniProt Synonym Protein Names   
Roof plate-specific spondin-1; hRspo1
 Protein Family    R-spondin
 UniProt Gene Name    RSPO1 [Similar Products]
 UniProt Synonym Gene Names    hRspo1 [Similar Products]
 UniProt Entry Name    RSPO1_HUMAN
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 NCBI Summary for RSPO1    This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
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 UniProt Comments for RSPO1    R-spondin-1: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Defects in RSPO1 are the cause of palmoplantar keratoderma with squamous cell carcinoma of skin and sex reversal (PKKSCC). This recessive syndrome is characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Belongs to the R-spondin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Cell adhesion; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: extracellular space; extracellular region; nucleus

Molecular Function: heparin binding; protein binding; G-protein-coupled receptor binding; receptor binding

Biological Process: regulation of gene expression; regulation of receptor internalization; Wnt receptor signaling pathway through beta-catenin; positive regulation of protein amino acid phosphorylation; male meiosis; positive regulation of Wnt receptor signaling pathway

Disease: Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,xx Sex Reversal
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 Research Articles on RSPO1    1. Changes in the expression levels of IRS1, IRS2, RIPK2, RSPO1, and DNA JC15 genes might contribute to the development of insulin resistance and glucose intolerance in the obese boys.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RSPO1 antibodyPathways associated with anti-RSPO1 antibody
 Reference Product  PubMed Publications
 LGR5 antibody  >24 publications with RSPO1 and LGR5
 LGR4 antibody  >20 publications with RSPO1 and LGR4
 RSPO2 antibody  >12 publications with RSPO1 and RSPO2
 RSPO4 antibody  >12 publications with RSPO1 and RSPO4
 DKK1 antibody  >11 publications with RSPO1 and DKK1
 LRP6 antibody  >11 publications with RSPO1 and LRP6
 RSPO3 antibody  >10 publications with RSPO1 and RSPO3
 LGR6 antibody  >9 publications with RSPO1 and LGR6
 ZNRF3 antibody  >9 publications with RSPO1 and ZNRF3
 RNF43 antibody  >6 publications with RSPO1 and RNF43
 Products by Pathway  Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 Wnt Signaling Network Pathway antibodies  Wnt Signaling Network Pathway Diagram
 Regulation Of FZD By Ubiquitination Pathway antibodies  Regulation Of FZD By Ubiquitination Pathway Diagram
Diseases associated with anti-RSPO1 antibodyOrgans/Tissues associated with anti-RSPO1 antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >26 publications with RSPO1 and Congenital Abnormalities
 Skin Diseases Antibodies  >5 publications with RSPO1 and Skin Diseases
 Inflammation Antibodies  >4 publications with RSPO1 and Inflammation
 Neoplasms, Experimental Antibodies  >3 publications with RSPO1 and Neoplasms, Experimental
 Necrosis Antibodies  >3 publications with RSPO1 and Necrosis
 Liver Diseases Antibodies  >2 publications with RSPO1 and Liver Diseases
 Ovarian Diseases Antibodies  >2 publications with RSPO1 and Ovarian Diseases
 Fibrosis Antibodies  >2 publications with RSPO1 and Fibrosis
 Hyperplasia Antibodies  >2 publications with RSPO1 and Hyperplasia
 Weight Loss Antibodies  >2 publications with RSPO1 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >37 publications with RSPO1 and Testis
 Ovary Antibodies  >35 publications with RSPO1 and Ovary
 Intestine Antibodies  >15 publications with RSPO1 and Intestine
 Pancreas Antibodies  >6 publications with RSPO1 and Pancreas
 Muscle Antibodies  >5 publications with RSPO1 and Muscle
 Brain Antibodies  >4 publications with RSPO1 and Brain
 Connective Tissue Antibodies  >3 publications with RSPO1 and Connective Tissue
 Eye Antibodies  >3 publications with RSPO1 and Eye
 Heart Antibodies  >2 publications with RSPO1 and Heart
 Prostate Antibodies  >1 publications with RSPO1 and Prostate
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