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anti-RAB5A antibody :: Mouse RAB5A Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140308 anti-RAB5A antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RAB5A, Monoclonal Antibody

 Also Known As   

Mouse Anti Human RAB5A

 Product Synonym Names    RAB5A Antibody; RAB5A, Mouse Anti Human; Ras-related protein Rab-5A; RAB5A; RAB5
 Product Gene Name   

anti-RAB5A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    179512
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 Clonality    Monoclonal
 Isotype    IgG2b heavy chain and kappa light chain
 Clone Number    P3A4AT
 Host    Mouse
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 Purity/Purification    RAB5A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
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 Immunogen    Anti-human RAB5A mAb is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human RAB5A amino acids 1-215 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-RAB5A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RAB5A antibody

   Introduction: RAB5A is a member of RAS oncogene family. The small GTPase, RAB5A is a crucial regulatory component of the endocytic pathway. Activation of RAB5A is mediated by GDP-GTP exchange factors (GEFs) that generate the Rab5-GTP complex). RAB5A is required for the fusion of plasma membranes and early endosomes.
 Product Categories/Family for anti-RAB5A antibody    MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies
 Applications Tested/Suitable for anti-RAB5A antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-RAB5A antibody    RAB5A antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000.Recommended starting dilution is 1:500.
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NCBI/Uniprot data below describe general gene information for RAB5A. It may not necessarily be applicable to this product.
 NCBI GI #    19923262
 NCBI GeneID    5868
 NCBI Accession #    NP_004153.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004162.4 [Other Products]
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 UniProt Secondary Accession #    Q6FI44; B4DJA5 [Other Products]
 UniProt Related Accession #    P20339 [Other Products]
 Molecular Weight    22,178 Da
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 NCBI Official Full Name    ras-related protein Rab-5A isoform 1
 NCBI Official Synonym Full Names    RAB5A, member RAS oncogene family
 NCBI Official Symbol    RAB5A [Similar Products]
 NCBI Official Synonym Symbols   
RAB5
[Similar Products]
 NCBI Protein Information    ras-related protein Rab-5A; RAS-associated protein RAB5A
 UniProt Protein Name    Ras-related protein Rab-5A
 Protein Family    Ras-related protein
 UniProt Gene Name    RAB5A [Similar Products]
 UniProt Synonym Gene Names    RAB5 [Similar Products]
 UniProt Entry Name    RAB5A_HUMAN
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 UniProt Comments for RAB5A    RAB5A: Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein; Motility/polarity/chemotaxis; G protein, monomeric, Rab; G protein, monomeric

Chromosomal Location of Human Ortholog: 3p24-p22

Cellular Component: zymogen granule membrane; protein complex; dendrite; early endosome; terminal button; phagocytic vesicle; cytosol; lipid raft; actin cytoskeleton; ruffle; recycling endosome; synaptic vesicle; cell soma; axon; endocytic vesicle; perinuclear region of cytoplasm; cytoplasm; melanosome; plasma membrane; endosome membrane; nerve terminal; endosome

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; GDP-dissociation inhibitor binding

Biological Process: regulation of long-term neuronal synaptic plasticity; intracellular protein transport; regulation of endosome size; early endosome to late endosome transport; positive regulation of smooth muscle cell proliferation; regulation of endocytosis; endocytosis; regulation of filopodium formation; positive regulation of smooth muscle cell migration; blood coagulation; Rab protein signal transduction; positive regulation of exocytosis
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 Research Articles on RAB5A    1. FGF21 has a role in promoting endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RAB5A antibodyPathways associated with anti-RAB5A antibody
 Reference Product  PubMed Publications
 EEA1 antibody  >12 publications with RAB5A and EEA1
 RIN1 antibody  >5 publications with RAB5A and RIN1
 CFTR antibody  >2 publications with RAB5A and CFTR
 ALS2 antibody  >1 publications with RAB5A and ALS2
 ZFYVE20 antibody  >1 publications with RAB5A and ZFYVE20
 RABEP1 antibody  >1 publications with RAB5A and RABEP1
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
Diseases associated with anti-RAB5A antibodyOrgans/Tissues associated with anti-RAB5A antibody
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >10 publications with RAB5A and Neoplasm Metastasis
 Inflammation Antibodies  >8 publications with RAB5A and Inflammation
 Death Antibodies  >5 publications with RAB5A and Death
 Liver Diseases Antibodies  >4 publications with RAB5A and Liver Diseases
 Kidney Diseases Antibodies  >4 publications with RAB5A and Kidney Diseases
 Brain Diseases Antibodies  >3 publications with RAB5A and Brain Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with RAB5A and Carcinoma, Hepatocellular
 Weight Loss Antibodies  >2 publications with RAB5A and Weight Loss
 Fibrosis Antibodies  >2 publications with RAB5A and Fibrosis
 Pain Antibodies  >2 publications with RAB5A and Pain
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with RAB5A and Brain
 Kidney Antibodies  >16 publications with RAB5A and Kidney
 Lung Antibodies  >13 publications with RAB5A and Lung
 Blood Antibodies  >13 publications with RAB5A and Blood
 Nerve Antibodies  >9 publications with RAB5A and Nerve
 Liver Antibodies  >8 publications with RAB5A and Liver
 Heart Antibodies  >7 publications with RAB5A and Heart
 Vascular Antibodies  >7 publications with RAB5A and Vascular
 Muscle Antibodies  >6 publications with RAB5A and Muscle
 Placenta Antibodies  >5 publications with RAB5A and Placenta
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