NP_002844.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
7,576 Da
NCBI Official Full Name
cell cycle checkpoint protein RAD1
NCBI Official Synonym Full Names
RAD1 checkpoint DNA exonuclease
NCBI Official Synonym Symbols
NCBI Protein Information
cell cycle checkpoint protein RAD1; RAD1 homolog; exonuclease homolog RAD1; DNA repair exonuclease REC1; checkpoint control protein HRAD1; DNA repair exonuclease rad1 homolog; cell cycle checkpoint protein Hrad1; rad1-like DNA damage checkpoint protein
UniProt Protein Name
Cell cycle checkpoint protein RAD1
UniProt Synonym Protein Names
DNA repair exonuclease rad1 homolog; Rad1-like DNA damage checkpoint protein
UniProt Synonym Gene Names
UniProt Entry Name
RAD1_HUMAN
NCBI Summary for RAD1
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]
UniProt Comments for RAD1
RAD1: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity. Belongs to the rad1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; DNA repair, damage; Deoxyribonuclease; EC 3.1.11.2
Chromosomal Location of Human Ortholog: 5p13.2
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; chromosome; nucleus
Molecular Function: protein binding; damaged DNA binding; exodeoxyribonuclease III activity; 3'-5' exonuclease activity
Biological Process: meiotic recombination checkpoint; substantia nigra development; DNA damage checkpoint; DNA replication; DNA catabolic process, exonucleolytic; DNA repair; response to DNA damage stimulus
Research Articles on RAD1
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Products associated with anti-RAD1 antibody
Pathways associated with anti-RAD1 antibody
Diseases associated with anti-RAD1 antibody
Organs/Tissues associated with anti-RAD1 antibody
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