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anti-RARG antibody :: Mouse anti-Human RARG Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120110
Quality Control
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RARG, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human RARG

 Product Synonym Names    Homo sapiens retinoic acid receptor, gamma (RARG), mRNA; RARC; NR1B3
 Product Gene Name   

anti-RARG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    180190
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    167C1a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-RARG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RARG antibody

   This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression.
 Applications Tested/Suitable for anti-RARG antibody   

Dot Blot (DB)

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 Quality Control of anti-RARG antibody    Left: Western blot analysis of immunized recombinant protein, using anti-RARG monoclonal antibody.
anti-RARG antibody Quality Control image
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NCBI/Uniprot data below describe general gene information for RARG. It may not necessarily be applicable to this product.
 NCBI GI #    344030233
 NCBI GeneID    5916
 NCBI Accession #    NP_000957.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000966 [Other Products]
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 UniProt Secondary Accession #    P22932; Q15281; Q52LZ8; Q9BYX8; Q9H1I3; Q9UJ38; B7Z492; B7Z4F1; B7ZAE4; J3KNP6 [Other Products]
 UniProt Related Accession #    P13631 [Other Products]
 Molecular Weight    47,931 Da
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 NCBI Official Full Name    Homo sapiens retinoic acid receptor, gamma (RARG), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    retinoic acid receptor, gamma
 NCBI Official Symbol    RARG [Similar Products]
 NCBI Official Synonym Symbols   
RARC; NR1B3
[Similar Products]
 NCBI Protein Information    retinoic acid receptor gamma; RAR-gamma; nuclear receptor subfamily 1 group B member 3; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2
 UniProt Protein Name    Retinoic acid receptor gamma
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 1 group B member 3
 Protein Family    Retinoic acid receptor
 UniProt Gene Name    RARG [Similar Products]
 UniProt Entry Name    RARG_HUMAN
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 NCBI Summary for RARG    This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
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 UniProt Comments for RARG    RARG: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function. Homodimer. Heterodimer with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Forms a complex with PUS1 and the SRA1 RNA in the nucleus. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: nucleoplasm; transcription factor complex; nuclear chromatin; integral to membrane; nucleus

Molecular Function: retinoid X receptor binding; protein binding; DNA binding; zinc ion binding; steroid hormone receptor activity; retinoic acid receptor activity; transcription factor activity

Biological Process: retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; response to retinoic acid; regulation of myelination; glandular epithelial cell development; embryonic eye morphogenesis; positive regulation of apoptosis; multicellular organism growth; negative regulation of chondrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; embryonic hindlimb morphogenesis; embryonic camera-type eye development; anterior/posterior pattern formation; negative regulation of cell proliferation; positive regulation of programmed cell death; neural tube closure; positive regulation of cell proliferation; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; transmembrane transport; regulation of cell size; negative regulation of apoptosis
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 Research Articles on RARG    1. The current status of knowledge indicates that there might be inter- or overlapping actions between PPARg and RARs, and there might be an association of PPARg/RARs(RARa, RARb, and RARg) with renal diseases
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RARG antibodyPathways associated with anti-RARG antibody
 Reference Product  PubMed Publications
 PPARG antibody  >3 publications with RARG and PPARG
 RXRA antibody  >3 publications with RARG and RXRA
 VDR antibody  >2 publications with RARG and VDR
 PPARA antibody  >1 publications with RARG and PPARA
 ESR1 antibody  >1 publications with RARG and ESR1
 RXRG antibody  >1 publications with RARG and RXRG
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
 Orphan Transporters Pathway antibodies  Orphan Transporters Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Retinoic Acid Pathway antibodies  Signaling By Retinoic Acid Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Vitamin A And Carotenoid Metabolism Pathway antibodies  Vitamin A And Carotenoid Metabolism Pathway Diagram
Diseases associated with anti-RARG antibodyOrgans/Tissues associated with anti-RARG antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >7 publications with RARG and Congenital Abnormalities
 Nervous System Malformations Antibodies  >3 publications with RARG and Nervous System Malformations
 Neural Tube Defects Antibodies  >3 publications with RARG and Neural Tube Defects
 Abnormalities, Multiple Antibodies  >3 publications with RARG and Abnormalities, Multiple
 Musculoskeletal Abnormalities Antibodies  >3 publications with RARG and Musculoskeletal Abnormalities
 Lung Neoplasms Antibodies  >2 publications with RARG and Lung Neoplasms
 Kidney Diseases Antibodies  >2 publications with RARG and Kidney Diseases
 Inflammation Antibodies  >2 publications with RARG and Inflammation
 Anemia Antibodies  >1 publications with RARG and Anemia
 Breast Neoplasms Antibodies  >1 publications with RARG and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >7 publications with RARG and Bone
 Blood Antibodies  >4 publications with RARG and Blood
 Embryonic Tissue Antibodies  >4 publications with RARG and Embryonic Tissue
 Kidney Antibodies  >3 publications with RARG and Kidney
 Brain Antibodies  >3 publications with RARG and Brain
 Testis Antibodies  >3 publications with RARG and Testis
 Liver Antibodies  >3 publications with RARG and Liver
 Lung Antibodies  >3 publications with RARG and Lung
 Vascular Antibodies  >2 publications with RARG and Vascular
 Connective Tissue Antibodies  >2 publications with RARG and Connective Tissue
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