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anti-RASSF1 antibody :: Mouse anti-Human RASSF1A Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS603739 anti-RASSF1 antibody
Unit / Price
0.05 mL  /  $350 +1 FREE 8GB USB
0.1 mL  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RASSF1A, Monoclonal Antibody

★Popular Item★
 Also Known As   

RASSF1A

 Product Synonym Names    Anti -RASSF1A
 Product Gene Name   

anti-RASSF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (50367217..50378367, complement). Location: 3p21.3
 OMIM    605082
 3D Structure    ModBase 3D Structure for Q9NS23
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    5G1
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human RASSF1A.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4.
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 Immunogen    Recombinant corresponding to aa1-340 from human RASSF1A purified from E. coli.
 Hybridoma    Mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human RASSF1A protein.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-RASSF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RASSF1 antibody

   The tumor suppressor gene RASSF1A (3p21.3), human Ras association domain family 1A, is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, small intestine, colon, and peripheral blood leukocytes. RASSF1A expression is inhibited by hypermethylation of the CpG island including the promoter and early transcribed regions of the human RASSF1A gene. Hypermethylated RASSF1A promoter is observed in primary tumors. Furthermore, RASSF1A is related with cell cycle regulation, apoptosis and microtubule stability.
 Product Categories/Family for anti-RASSF1 antibody    Antibodies; Abs to Apoptosis
 Applications Tested/Suitable for anti-RASSF1 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-RASSF1 antibody    Suitable for use in ELISA, Western Blot and Immunofluorescence (IF-IC).
Dilution: Western Blot:1:500-1:2000
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NCBI/Uniprot data below describe general gene information for RASSF1. It may not necessarily be applicable to this product.
 NCBI GI #    332701155
 NCBI GeneID    11186
 NCBI Accession #    NP_001193886.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206957.1 [Other Products]
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 UniProt Primary Accession #    Q9NS23 [Other Products]
 UniProt Secondary Accession #    O14571; O60539; O60710; Q0VGC6; Q5TZT2; Q9HB04; Q9HB18; Q9NS22; Q9UND4; Q9UND5; B7ZLL1 [Other Products]
 UniProt Related Accession #    Q9NS23 [Other Products]
 Molecular Weight    39,219 Da [Similar Products]
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 NCBI Official Full Name    ras association domain-containing protein 1 isoform B
 NCBI Official Synonym Full Names    Ras association (RalGDS/AF-6) domain family member 1
 NCBI Official Symbol    RASSF1 [Similar Products]
 NCBI Official Synonym Symbols   
123F2; RDA32; NORE2A; RASSF1A; REH3P21
[Similar Products]
 NCBI Protein Information    ras association domain-containing protein 1; WUGSC:H_LUCA12.5; tumor suppressor protein RDA32; cardiac-specific ras association domain family 1 protein; pancreas-specific ras association domain family 1 protein
 UniProt Protein Name    Ras association domain-containing protein 1
 Protein Family    Ras association domain-containing protein
 UniProt Gene Name    RASSF1 [Similar Products]
 UniProt Synonym Gene Names    RDA32 [Similar Products]
 UniProt Entry Name    RASF1_HUMAN
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 NCBI Summary for RASSF1    This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]
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 UniProt Comments for RASSF1    RASSF1: Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. Interacts with MAP1S and XPA. Binds to the N-terminal of CDC20 during prometaphase. Binds to STK3/MST2 and STK4/MST1. Isoform A interacts with MOAP1 and E4F1. Recruited to the TNFRSF1A and TNFRSF10A complexes in response to their respective cognate ligand, after internalization. Can self-associate. Isoform A interacts with RSSF5 and probably associates with HRAS1 via a RSSF1 isoform A-RSSF5 heterodimer. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Isoform A interacts (via C-terminus) with DAXX (via N-terminus); the interaction is independent of MDM2 and TP53. Isoform C or isoform H interacts (via N-terminus) with DAXX. Isoform A interacts (via N-terminus) with MDM2 (via C-terminus); the interaction is independent of TP53. Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells. 8 isoforms of the human protein are produced by alternative promoter.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: microtubule cytoskeleton; spindle pole; microtubule; cytoplasm; plasma membrane; microtubule organizing center; nucleus

Molecular Function: identical protein binding; protein binding; zinc ion binding; protein N-terminus binding

Biological Process: protein stabilization; positive regulation of protein ubiquitination; Ras protein signal transduction; cell cycle arrest; response to DNA damage stimulus

Disease: Lung Cancer
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 Research Articles on RASSF1    1. Aim of this work is to provide a detailed comparison of clinical-pathologic features between well-differentiated and poorly differentiated tumors according to their BRAF and RASSF1A status.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-RASSF1 antibodyDiseases associated with anti-RASSF1 antibody
 Products by Pathway  Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 P53 Pathway antibodies  P53 Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >636 publications with RASSF1 and Neoplasms
 Carcinoma Antibodies  >338 publications with RASSF1 and Carcinoma
 Lung Neoplasms Antibodies  >175 publications with RASSF1 and Lung Neoplasms
 Adenocarcinoma Antibodies  >173 publications with RASSF1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >135 publications with RASSF1 and Breast Neoplasms
 Lung Diseases Antibodies  >131 publications with RASSF1 and Lung Diseases
 Carcinoma, Non-Small-Cell Lung Antibodies  >75 publications with RASSF1 and Carcinoma, Non-Small-Cell Lung
 Neoplasms, Experimental Antibodies  >70 publications with RASSF1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >53 publications with RASSF1 and Liver Neoplasms
 Kidney Neoplasms Antibodies  >44 publications with RASSF1 and Kidney Neoplasms
Organs/Tissues associated with anti-RASSF1 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >188 publications with RASSF1 and Lung
 Blood Antibodies  >105 publications with RASSF1 and Blood
 Liver Antibodies  >55 publications with RASSF1 and Liver
 Prostate Antibodies  >53 publications with RASSF1 and Prostate
 Kidney Antibodies  >44 publications with RASSF1 and Kidney
 Lymph Antibodies  >42 publications with RASSF1 and Lymph
 Lymph Node Antibodies  >42 publications with RASSF1 and Lymph Node
 Brain Antibodies  >26 publications with RASSF1 and Brain
 Stomach Antibodies  >20 publications with RASSF1 and Stomach
 Skin Antibodies  >17 publications with RASSF1 and Skin
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