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anti-RB1 antibody :: Mouse anti-Human RB1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120046
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RB1, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human RB1

 Product Synonym Names    retinoblastoma 1 (including osteosarcoma) (RB1); RB; OSRC
 Product Gene Name   

anti-RB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109800
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    RB1AD56A
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-RB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RB1 antibody

   Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression ('cure') occurs in some cases.[supplied by OMIM] [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-RB1 antibody   

Dot Blot (DB), ELISA (EIA), Immunocytochemistry (ICC)

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 Quality Control of anti-RB1 antibody    Western blot analysis of immunized recombinant protein, using anti-RB1 monoclonal antibody.
anti-RB1 antibody Quality Control image
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 Quality Control #2 of anti-RB1 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-RB1 antibody Quality Control #2 image
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 Immunocytochemistry (ICC) of anti-RB1 antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-RB1 mAb. [Lot No. RB1AD56A-3]
anti-RB1 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for RB1. It may not necessarily be applicable to this product.
 NCBI GI #    108773786
 NCBI GeneID    5925
 NCBI Accession #    NP_000312.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000321 [Other Products]
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 UniProt Secondary Accession #    P78499; Q5VW46; Q8IZL4; A8K5E3 [Other Products]
 UniProt Related Accession #    P06400 [Other Products]
 Molecular Weight    106,159 Da
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 NCBI Official Full Name    Homo sapiens retinoblastoma 1 (RB1), mRNA
 NCBI Official Synonym Full Names    retinoblastoma 1
 NCBI Official Symbol    RB1 [Similar Products]
 NCBI Official Synonym Symbols   
RB; pRb; OSRC; pp110; p105-Rb; PPP1R130
[Similar Products]
 NCBI Protein Information    retinoblastoma-associated protein; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; retinoblastoma suspectibility protein
 UniProt Protein Name    Retinoblastoma-associated protein
 UniProt Synonym Protein Names   
p105-Rb; pRb; Rb; pp110
 Protein Family    RB1-inducible coiled-coil protein
 UniProt Gene Name    RB1 [Similar Products]
 UniProt Entry Name    RB_HUMAN
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 NCBI Summary for RB1    The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RB1    Rb: retinoblastoma tumor suppressor protein regulates cell proliferation by controlling progression through the G1-phase restriction point. Has three distinct binding domains and interacts with regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase and proteins with a conserved LXCXE motif. Cell cycle-dependent phosphorylation by Cdks inhibits Rb target binding, thus allowing cell cycle progression. Recruits and targets histone methyltransferase suv39h1 leading to epigenetic transcriptional repression.

Protein type: Tumor suppressor; Oncoprotein; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 13q14.2

Cellular Component: nucleoplasm; SWI/SNF complex; PML body; Rb-E2F complex; spindle; chromatin; nucleus

Molecular Function: identical protein binding; protein binding; DNA binding; androgen receptor binding; ubiquitin protein ligase binding; transcription coactivator activity; phosphoprotein binding; kinase binding; transcription factor binding; transcription factor activity

Biological Process: sister chromatid biorientation; viral reproduction; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter, mitotic; regulation of mitotic cell cycle; neuron maturation; positive regulation of macrophage differentiation; cell cycle arrest; neurite development; negative regulation of epithelial cell proliferation; transcription, DNA-dependent; mitotic cell cycle checkpoint; negative regulation of transcription factor activity; enucleate erythrocyte differentiation; regulation of lipid kinase activity; myoblast differentiation; chromatin remodeling; G1/S-specific transcription in mitotic cell cycle; neuron apoptosis; maintenance of mitotic sister chromatid cohesion; gut development; cell division; negative regulation of smoothened signaling pathway; neuron morphogenesis during differentiation; androgen receptor signaling pathway; Ras protein signal transduction; positive regulation of mitotic metaphase/anaphase transition; striated muscle cell differentiation; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; negative regulation of transcription, DNA-dependent; cell cycle checkpoint; G1/S transition of mitotic cell cycle

Disease: Bladder Cancer; Osteogenic Sarcoma; Small Cell Cancer Of The Lung; Retinoblastoma
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 Research Articles on RB1    1. excess E2F1 due to Rb inactivation recruits the complex of Cdc20 and the anaphase-promoting complex/cyclosome to deregulate the expression of UBCH10
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RB1 antibodyPathways associated with anti-RB1 antibody
 Reference Product  PubMed Publications
 CCND1 antibody  >108 publications with RB1 and CCND1
 CDK4 antibody  >81 publications with RB1 and CDK4
 MDM2 antibody  >68 publications with RB1 and MDM2
 E2F1 antibody  >54 publications with RB1 and E2F1
 E2F3 antibody  >22 publications with RB1 and E2F3
 CDK2 antibody  >21 publications with RB1 and CDK2
 CCNE1 antibody  >11 publications with RB1 and CCNE1
 HDAC1 antibody  >7 publications with RB1 and HDAC1
 RBBP4 antibody  >3 publications with RB1 and RBBP4
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-RB1 antibodyOrgans/Tissues associated with anti-RB1 antibody
 Disease Name  Pubmed Publications
 Retinoblastoma Antibodies  >1112 publications with RB1 and Retinoblastoma
 Carcinoma Antibodies  >301 publications with RB1 and Carcinoma
 Adenocarcinoma Antibodies  >130 publications with RB1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >127 publications with RB1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >94 publications with RB1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >84 publications with RB1 and Neoplasms, Experimental
 Osteosarcoma Antibodies  >76 publications with RB1 and Osteosarcoma
 Liver Diseases Antibodies  >60 publications with RB1 and Liver Diseases
 Liver Neoplasms Antibodies  >50 publications with RB1 and Liver Neoplasms
 Necrosis Antibodies  >48 publications with RB1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >319 publications with RB1 and Blood
 Eye Antibodies  >232 publications with RB1 and Eye
 Brain Antibodies  >214 publications with RB1 and Brain
 Lung Antibodies  >144 publications with RB1 and Lung
 Bone Antibodies  >112 publications with RB1 and Bone
 Liver Antibodies  >109 publications with RB1 and Liver
 Muscle Antibodies  >88 publications with RB1 and Muscle
 Skin Antibodies  >62 publications with RB1 and Skin
 Intestine Antibodies  >60 publications with RB1 and Intestine
 Prostate Antibodies  >58 publications with RB1 and Prostate
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