NP_056958.3
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,297 Da
NCBI Official Full Name
recombining binding protein suppressor of hairless isoform 2
NCBI Official Synonym Full Names
recombination signal binding protein for immunoglobulin kappa J region
NCBI Official Synonym Symbols
SUH; csl; AOS3; CBF1; KBF2; RBP-J; RBPJK; IGKJRB; RBPSUH; IGKJRB1 [Similar Products]
NCBI Protein Information
recombining binding protein suppressor of hairless
UniProt Protein Name
Recombining binding protein suppressor of hairless
UniProt Synonym Protein Names
CBF-1; J kappa-recombination signal-binding protein; RBP-J kappa; RBP-J; RBP-JK; Renal carcinoma antigen NY-REN-30
UniProt Synonym Gene Names
UniProt Entry Name
SUH_HUMAN
NCBI Summary for RBPSUH
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
UniProt Comments for RBPSUH
RBPJ: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Interacts with activated NOTCH1, NOTCH2 or NOTCH3. Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR1. Interacts with EP300, MAML1 and PTF1A. Interacts with Epstein-Barr virus EBNA2, EBNA3, EBNA4 and EBNA6. Interacts with RITA/C12orf52, leading to nuclear export, prevent the interaction between RBPJ and NICD product and subsequent down-regulation of the Notch signaling pathway. Belongs to the Su(H) family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Cell development/differentiation
Chromosomal Location of Human Ortholog: 4p15.2
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; recombinase activity; protein N-terminus binding; chromatin binding; transcription factor activity
Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; epidermal cell fate specification; somatic stem cell maintenance; sebaceous gland development; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; hair follicle maturation; humoral immune response; activation of Notch receptor target transcription factor; DNA recombination; keratinocyte differentiation; negative regulation of cell proliferation; inflammatory response to antigenic stimulus; pituitary gland development; B cell differentiation; defense response to bacterium; negative regulation of ossification; epithelial to mesenchymal transition; gene expression; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; angiogenesis; auditory receptor cell fate commitment; negative regulation of transcription, DNA-dependent; regulation of timing of cell differentiation; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation
Disease: Adams-oliver Syndrome 3
Research Articles on RBPSUH
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-RBPSUH antibody
Pathways associated with anti-RBPSUH antibody
Diseases associated with anti-RBPSUH antibody
Organs/Tissues associated with anti-RBPSUH antibody
|