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anti-RBPSUH antibody :: Mouse RBPSUH Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS533365
Western Blot
Unit / Price
0.05 mg  /  $275 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RBPSUH, Monoclonal Antibody

 Also Known As   

RBPSUH antibody

 Product Synonym Names    Monoclonal RBPSUH; Anti-RBPSUH; IGKJRB1; RBP-J; Recombination signal binding protein for immunoglobulin kappa J region; RBPSUH; KBF2; IGKJRB; csl; RBPJK; MGC61669; Anti RBPSUH; CBF1
 Product Gene Name   

anti-RBPSUH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147183
 3D Structure    ModBase 3D Structure for Q06330
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    RPBSD18
 Host    Mouse
 Species Reactivity    Human. Other species not studied
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 Specificity    Human RBPSUH
 Purity/Purification    RBPSUH antibody was purified using protein G column chromatography from culture supernatant of hybridomacultured in a medium containing bovine IgG-depleted(approximately 95%) fetal bovine serum.
 Form/Format    RBPSUH antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4, 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3).
 Concentration    100 ug/ml (lot specific)
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 Biological Significance    RBPSUH is a transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate. determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histoneacetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence.
 Biohazard Information    This antibody solution contains sodium azide as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly advised that this product should be handled by people who have been well trained in laboratory techniques and that it is handled with care pursuant to the principles of good laboratory practice.
 Immunogen    RBPSUH antibody was raised in mouse using recombinant Recombining Binding Protein Suppressor Of Hairless (Drosophila) (Rbpsuh)
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 Preparation and Storage    Store at 2-8 degree C for up to one year. We recommend long term storage at -20 degree C. Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-RBPSUH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-RBPSUH antibody

   Mouse monoclonal RBPSUH antibody
 Product Categories/Family for anti-RBPSUH antibody    DNA & RNA
 Applications Tested/Suitable for anti-RBPSUH antibody   

Dot Blot (DB)

 Application Notes for anti-RBPSUH antibody    To be optimized by the end user.
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 Western Blot of anti-RBPSUH antibody    Western Blot analysis of immunized recombinant protein using RBPSUH antibody
anti-RBPSUH antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for RBPSUH. It may not necessarily be applicable to this product.
 NCBI GI #    42560229
 NCBI GeneID    3516
 NCBI Accession #    NP_056958.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_015874.4 [Other Products]
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 UniProt Primary Accession #    Q06330 [Other Products]
 UniProt Secondary Accession #    Q5XKH9; Q6P1N3; B4DY22 [Other Products]
 UniProt Related Accession #    Q06330 [Other Products]
 Molecular Weight    54,297 Da
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 NCBI Official Full Name    recombining binding protein suppressor of hairless isoform 2
 NCBI Official Synonym Full Names    recombination signal binding protein for immunoglobulin kappa J region
 NCBI Official Symbol    RBPJ [Similar Products]
 NCBI Official Synonym Symbols   
SUH; csl; AOS3; CBF1; KBF2; RBP-J; RBPJK; IGKJRB; RBPSUH; IGKJRB1
[Similar Products]
 NCBI Protein Information    recombining binding protein suppressor of hairless
 UniProt Protein Name    Recombining binding protein suppressor of hairless
 UniProt Synonym Protein Names   
CBF-1; J kappa-recombination signal-binding protein; RBP-J kappa; RBP-J; RBP-JK; Renal carcinoma antigen NY-REN-30
 UniProt Gene Name    RBPJ [Similar Products]
 UniProt Synonym Gene Names    IGKJRB; IGKJRB1; RBPJK; RBPSUH; RBP-J; RBP-JK [Similar Products]
 UniProt Entry Name    SUH_HUMAN
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 NCBI Summary for RBPSUH    The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
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 UniProt Comments for RBPSUH    RBPJ: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Interacts with activated NOTCH1, NOTCH2 or NOTCH3. Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR1. Interacts with EP300, MAML1 and PTF1A. Interacts with Epstein-Barr virus EBNA2, EBNA3, EBNA4 and EBNA6. Interacts with RITA/C12orf52, leading to nuclear export, prevent the interaction between RBPJ and NICD product and subsequent down-regulation of the Notch signaling pathway. Belongs to the Su(H) family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4p15.2

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; DNA binding; recombinase activity; protein N-terminus binding; chromatin binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; epidermal cell fate specification; somatic stem cell maintenance; sebaceous gland development; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; hair follicle maturation; humoral immune response; activation of Notch receptor target transcription factor; DNA recombination; keratinocyte differentiation; negative regulation of cell proliferation; inflammatory response to antigenic stimulus; pituitary gland development; B cell differentiation; defense response to bacterium; negative regulation of ossification; epithelial to mesenchymal transition; gene expression; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; angiogenesis; auditory receptor cell fate commitment; negative regulation of transcription, DNA-dependent; regulation of timing of cell differentiation; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation

Disease: Adams-oliver Syndrome 3
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 Research Articles on RBPSUH    1. RBP-J-interacting and tubulin-associated (RITA) mediates the nuclear export of RBP-J to tubulin fibers and downregulates Notch-mediated transcription.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RBPSUH antibodyPathways associated with anti-RBPSUH antibody
 Reference Product  PubMed Publications
 NOTCH1 antibody  >144 publications with RBPSUH and NOTCH1
 NOTCH2 antibody  >32 publications with RBPSUH and NOTCH2
 NOTCH4 antibody  >22 publications with RBPSUH and NOTCH4
 MAML1 antibody  >19 publications with RBPSUH and MAML1
 NOTCH3 antibody  >18 publications with RBPSUH and NOTCH3
 HEY1 antibody  >15 publications with RBPSUH and HEY1
 HEY2 antibody  >6 publications with RBPSUH and HEY2
 NCOR2 antibody  >6 publications with RBPSUH and NCOR2
 SPEN antibody  >4 publications with RBPSUH and SPEN
 SNW1 antibody  >2 publications with RBPSUH and SNW1
 Products by Pathway  Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
Diseases associated with anti-RBPSUH antibodyOrgans/Tissues associated with anti-RBPSUH antibody
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >23 publications with RBPSUH and Cell Transformation, Neoplastic
 Carcinoma Antibodies  >21 publications with RBPSUH and Carcinoma
 Neoplasms, Experimental Antibodies  >20 publications with RBPSUH and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >15 publications with RBPSUH and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >13 publications with RBPSUH and Nervous System Diseases
 Inflammation Antibodies  >13 publications with RBPSUH and Inflammation
 Adenocarcinoma Antibodies  >9 publications with RBPSUH and Adenocarcinoma
 Hyperplasia Antibodies  >7 publications with RBPSUH and Hyperplasia
 Heart Diseases Antibodies  >7 publications with RBPSUH and Heart Diseases
 Necrosis Antibodies  >7 publications with RBPSUH and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >84 publications with RBPSUH and Blood
 Muscle Antibodies  >42 publications with RBPSUH and Muscle
 Bone Antibodies  >39 publications with RBPSUH and Bone
 Vascular Antibodies  >39 publications with RBPSUH and Vascular
 Embryonic Tissue Antibodies  >39 publications with RBPSUH and Embryonic Tissue
 Brain Antibodies  >36 publications with RBPSUH and Brain
 Nerve Antibodies  >26 publications with RBPSUH and Nerve
 Liver Antibodies  >24 publications with RBPSUH and Liver
 Bone Marrow Antibodies  >22 publications with RBPSUH and Bone Marrow
 Kidney Antibodies  >18 publications with RBPSUH and Kidney
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