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| Product Name
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RBPSUH, Monoclonal Antibody
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| Also Known As
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RBPSUH antibody
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| Product Synonym Names
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Monoclonal RBPSUH; Anti-RBPSUH; IGKJRB1; RBP-J; Recombination signal binding protein for immunoglobulin kappa J region; RBPSUH; KBF2; IGKJRB; csl; RBPJK; MGC61669; Anti RBPSUH; CBF1
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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147183
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| 3D Structure
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ModBase 3D Structure for Q06330
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| Clonality
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Monoclonal
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| Isotype
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IgG1
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| Clone Number
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RPBSD18
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| Host
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Mouse
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| Species Reactivity
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Human. Other species not studied
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| Specificity
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Human RBPSUH
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| Purity/Purification
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RBPSUH antibody was purified using protein G column chromatography from culture supernatant of hybridomacultured in a medium containing bovine IgG-depleted(approximately 95%) fetal bovine serum.
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| Form/Format
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RBPSUH antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4, 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3).
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| Concentration
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100 ug/ml (lot specific)
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| Biological Significance
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RBPSUH is a transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate. determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histoneacetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence.
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| Biohazard Information
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This antibody solution contains sodium azide as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly advised that this product should be handled by people who have been well trained in laboratory techniques and that it is handled with care pursuant to the principles of good laboratory practice.
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| Immunogen
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RBPSUH antibody was raised in mouse using recombinant Recombining Binding Protein Suppressor Of Hairless (Drosophila) (Rbpsuh)
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| Preparation and Storage
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Store at 2-8 degree C for up to one year. We recommend long term storage at -20 degree C. Avoid repeated freezing and thawing.
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| Other Notes
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Small volumes of anti-RBPSUH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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Mouse monoclonal RBPSUH antibody
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| Product Categories/Family for anti-RBPSUH antibody
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DNA & RNA
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| Applications Tested/Suitable for anti-RBPSUH antibody
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Dot Blot (DB)
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| Application Notes for anti-RBPSUH antibody
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To be optimized by the end user.
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| Western Blot of anti-RBPSUH antibody
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Western Blot analysis of immunized recombinant protein using RBPSUH antibody
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TOP
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| NCBI/Uniprot data below describe general gene information for RBPSUH. It may not necessarily be applicable to this product. |
| NCBI GI #
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42560229
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| NCBI GeneID
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3516
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| NCBI Accession #
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NP_056958.3
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_015874.4
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[Other Products]
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| UniProt Primary Accession #
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Q06330
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[Other Products]
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| UniProt Secondary Accession #
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Q5XKH9; Q6P1N3; B4DY22
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[Other Products]
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| UniProt Related Accession #
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Q06330
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[Other Products]
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| Molecular Weight
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54,297 Da
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TOP
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| NCBI Official Full Name
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recombining binding protein suppressor of hairless isoform 2
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| NCBI Official Synonym Full Names
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recombination signal binding protein for immunoglobulin kappa J region
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| NCBI Official Symbol
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RBPJ
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[Similar Products]
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| NCBI Official Synonym Symbols
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SUH; csl; AOS3; CBF1; KBF2; RBP-J; RBPJK; IGKJRB; RBPSUH; IGKJRB1
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[Similar Products]
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| NCBI Protein Information
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recombining binding protein suppressor of hairless
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| UniProt Protein Name
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Recombining binding protein suppressor of hairless
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| UniProt Synonym Protein Names
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CBF-1; J kappa-recombination signal-binding protein; RBP-J kappa; RBP-J; RBP-JK; Renal carcinoma antigen NY-REN-30
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| UniProt Gene Name
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RBPJ
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[Similar Products]
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| UniProt Synonym Gene Names
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IGKJRB; IGKJRB1; RBPJK; RBPSUH; RBP-J; RBP-JK
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[Similar Products]
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| UniProt Entry Name
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SUH_HUMAN
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| NCBI Summary for RBPSUH
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The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]
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| UniProt Comments for RBPSUH
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RBPJ: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Interacts with activated NOTCH1, NOTCH2 or NOTCH3. Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR1. Interacts with EP300, MAML1 and PTF1A. Interacts with Epstein-Barr virus EBNA2, EBNA3, EBNA4 and EBNA6. Interacts with RITA/C12orf52, leading to nuclear export, prevent the interaction between RBPJ and NICD product and subsequent down-regulation of the Notch signaling pathway. Belongs to the Su(H) family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Cell development/differentiation
Chromosomal Location of Human Ortholog: 4p15.2
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; recombinase activity; protein N-terminus binding; chromatin binding; transcription factor activity
Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; epidermal cell fate specification; somatic stem cell maintenance; sebaceous gland development; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; hair follicle maturation; humoral immune response; activation of Notch receptor target transcription factor; DNA recombination; keratinocyte differentiation; negative regulation of cell proliferation; inflammatory response to antigenic stimulus; pituitary gland development; B cell differentiation; defense response to bacterium; negative regulation of ossification; epithelial to mesenchymal transition; gene expression; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; angiogenesis; auditory receptor cell fate commitment; negative regulation of transcription, DNA-dependent; regulation of timing of cell differentiation; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation
Disease: Adams-oliver Syndrome 3
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TOP
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| Research Articles on RBPSUH
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1. RBP-J-interacting and tubulin-associated (RITA) mediates the nuclear export of RBP-J to tubulin fibers and downregulates Notch-mediated transcription.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with anti-RBPSUH antibody | Pathways associated with anti-RBPSUH antibody |
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| Diseases associated with anti-RBPSUH antibody | Organs/Tissues associated with anti-RBPSUH antibody |
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TOP
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Antibody 
