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anti-REXO2 antibody :: Mouse anti-Human REXO2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120308
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

REXO2, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human REXO2

 Product Synonym Names    Homo sapiens REX2, RNA exonuclease 2 homolog (S. cerevisiae); RFN; SFN; CGI-114; MGC111570; DKFZP566E144
 Product Gene Name   

anti-REXO2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607149
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    2276D6a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-REXO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-REXO2 antibody

   Nucleases are components of DNA and RNA metabolism that carry out functions in DNA repair, replication, and recombination and in RNA processing and degradation. SFN is a homolog of Orn, a 3-prime-to-5-prime exoribonuclease of E. coli that attacks the free 3-prime hydroxyl group on single-stranded RNA, releasing 5-prime mononucleotides in a sequential manner.[supplied by OMIM] [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-REXO2 antibody   

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

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 Quality Control of anti-REXO2 antibody    Western blot analysis of immunized recombinant protein, using anti-REXO2 monoclonal antibody.
anti-REXO2 antibody Quality Control image
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 Quality Control #2 of anti-REXO2 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-REXO2 antibody Quality Control #2 image
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 Western Blot (WB) of anti-REXO2 antibody    Detection of REXO2 by Western blot.

Samples: Whole cell lysate from human HeLa (H, 25 ug), mouse NIH3T3 (M, 25 ug) and rat F2408 (R, 25 ug) cells. [Lot No. 2276D6a-1]

Predicted molecular weight: 26 kDa
anti-REXO2 antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-REXO2 antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-REXO2 mAb. [Lot No. 2276D6a-1]
anti-REXO2 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for REXO2. It may not necessarily be applicable to this product.
 NCBI GI #    224496105
 NCBI GeneID    25996
 NCBI Accession #    NP_056338.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_015523 [Other Products]
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 UniProt Secondary Accession #    Q32Q18; Q53FT1; Q6FIC6; Q9UFY7; B2R532 [Other Products]
 UniProt Related Accession #    Q9Y3B8 [Other Products]
 Molecular Weight    23,754 Da
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 NCBI Official Full Name    Homo sapiens RNA exonuclease 2 (REXO2), mRNA
 NCBI Official Synonym Full Names    RNA exonuclease 2
 NCBI Official Symbol    REXO2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    oligoribonuclease, mitochondrial; REX2, RNA exonuclease 2 homolog; small fragment nuclease
 UniProt Protein Name    Oligoribonuclease, mitochondrial
 UniProt Synonym Protein Names   
RNA exonuclease 2 homolog; Small fragment nuclease
 UniProt Gene Name    REXO2 [Similar Products]
 UniProt Entry Name    ORN_HUMAN
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 NCBI Summary for REXO2    This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
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 UniProt Comments for REXO2    REXO2: a 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role for cellular nucleotide recycling. Two splice variant isoforms have been described: mitochondrial (isoform 1) and nuclear (isoform 2).

Protein type: Hydrolase; EC 3.1.-.-

Chromosomal Location of Human Ortholog: 11q23.2

Cellular Component: focal adhesion; mitochondrion; mitochondrial matrix; nucleolus; mitochondrial intermembrane space; nucleus

Molecular Function: 3'-5'-exoribonuclease activity; nucleic acid binding; 3'-5' exonuclease activity

Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; nucleotide metabolic process
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 Research Articles on REXO2    1. Loss of 14-3-3sigma sensitizes cells to UVB. After a transient cell cycle arrest, 14-3-3sigma-deficient cells die by undergoing mitotic catastrophe.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-REXO2 antibody
 Products by Pathway  Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
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