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anti-RIPK3 antibody :: Mouse anti-Human RIP3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS603758 anti-RIPK3 antibody
Unit / Price
0.1 mg  /  $645 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RIP3 (RIPK3), Monoclonal Antibody

 Also Known As   

RIP3 (Receptor Interacting Protein 3)

 Product Synonym Names    Anti -RIP3 (Receptor Interacting Protein 3)
 Product Gene Name   

anti-RIPK3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_000014.8 (24805227..24809242, complement). Location: 14q11.2
 OMIM    605817
 3D Structure    ModBase 3D Structure for Q9Y572
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    6D746
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human RIP3.
 Purity/Purification    Highly Purified
Highly purified (SDS-PAGE).
 Form/Format    Liquid. Purified antibody in PBS containing 0.02% sodium azide.
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 Immunogen    Recombinant human RIP3.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-RIPK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-RIPK3 antibody

   Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNF-R1 and Fas, two prototype members in the death receptor family. A member in the RIP kinase family was identified and designated RIP3 [1-3]. RIP3 contains an N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNF-R1, mediates TNF-R1 induced apoptosis, and attenuates RIP and TNF-R1 induced NF- B activation. Overexpression of RIP3 induces apoptosis and NF- B activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues [2,3]. Meanwhile RIP4 has been identified and initially characterized. These data suggest that RIP4 is involved in NF- B and JNK signalling and that caspase-dependent processing of RIP4 may negatively regulate NF- B-dependent pro-survival or pro-inflammatory signals [4].
 Product Categories/Family for anti-RIPK3 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-RIPK3 antibody   

Western Blot (WB)

 Application Notes for anti-RIPK3 antibody    Suitable for use in Western Blot.
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NCBI/Uniprot data below describe general gene information for RIPK3. It may not necessarily be applicable to this product.
 NCBI GI #    40254844
 NCBI GeneID    11035
 NCBI Accession #    NP_006862.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006871.3 [Other Products]
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 UniProt Primary Accession #    Q9Y572 [Other Products]
 UniProt Secondary Accession #    Q5J795; Q5J796; Q6P5Y1; B4DJL9; C4AM87 [Other Products]
 UniProt Related Accession #    Q9Y572 [Other Products]
 Molecular Weight    56,887 Da [Similar Products]
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 NCBI Official Full Name    receptor-interacting serine/threonine-protein kinase 3
 NCBI Official Synonym Full Names    receptor-interacting serine-threonine kinase 3
 NCBI Official Symbol    RIPK3 [Similar Products]
 NCBI Official Synonym Symbols   
RIP3
[Similar Products]
 NCBI Protein Information    receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; receptor interacting protein 3; receptor-interacting protein 3
 UniProt Protein Name    Receptor-interacting serine/threonine-protein kinase 3
 UniProt Synonym Protein Names   
RIP-like protein kinase 3; Receptor-interacting protein 3
 Protein Family    Receptor-interacting serine/threonine-protein kinase
 UniProt Gene Name    RIPK3 [Similar Products]
 UniProt Synonym Gene Names    RIP3; RIP-3 [Similar Products]
 UniProt Entry Name    RIPK3_HUMAN
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 NCBI Summary for RIPK3    The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RIPK3    RIPK3: Promotes apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Binds TRAF2 and RIPK1 and is recruited to the TNFR-1 signaling complex. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.1; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; RIPK family

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: mitochondrion; plasma membrane; cytosol

Molecular Function: NF-kappaB-inducing kinase activity; identical protein binding; protein serine/threonine kinase activity; protein binding; transcription coactivator activity; protein complex binding; ATP binding; protein kinase activity

Biological Process: spleen development; regulation of activated T cell proliferation; I-kappaB kinase/NF-kappaB cascade; thymus development; protein heterooligomerization; protein amino acid autophosphorylation; MyD88-independent toll-like receptor signaling pathway; T cell differentiation in the thymus; protein modification process; toll-like receptor 3 signaling pathway; signal transduction; lymph node development; activation of NF-kappaB transcription factor; regulation of T cell mediated cytotoxicity; regulation of adaptive immune response; regulation of interferon-gamma production; toll-like receptor signaling pathway; activation of protein kinase activity; positive regulation of interferon type I production; innate immune response; T cell homeostasis; positive regulation of ligase activity; toll-like receptor 4 signaling pathway; protein homooligomerization; positive regulation of oxidoreductase activity
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 Research Articles on RIPK3    1. the importance of the RIP3-MLKL interaction in the formation of functional necrosomes and suggest that translocation of necrosomes to mitochondria-associated membranes is essential for necroptosis signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RIPK3 antibodyPathways associated with anti-RIPK3 antibody
 Reference Product  PubMed Publications
 RIPK1 antibody  >39 publications with RIPK3 and RIPK1
 MLKL antibody  >9 publications with RIPK3 and MLKL
 ZBP1 antibody  >3 publications with RIPK3 and ZBP1
 RELA antibody  >2 publications with RIPK3 and RELA
 TLR3 antibody  >2 publications with RIPK3 and TLR3
 TICAM1 antibody  >1 publications with RIPK3 and TICAM1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 IKK Complex Recruitment Mediated By RIP1 Pathway antibodies  IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88-independent Cascade Pathway antibodies  MyD88-independent Cascade Pathway Diagram
 RIP-mediated NFkB Activation Via ZBP1 Pathway antibodies  RIP-mediated NFkB Activation Via ZBP1 Pathway Diagram
 TNF Signaling Pathway antibodies  TNF Signaling Pathway Diagram
Diseases associated with anti-RIPK3 antibodyOrgans/Tissues associated with anti-RIPK3 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >88 publications with RIPK3 and Necrosis
 Inflammation Antibodies  >30 publications with RIPK3 and Inflammation
 Cardiovascular Diseases Antibodies  >8 publications with RIPK3 and Cardiovascular Diseases
 Liver Diseases Antibodies  >5 publications with RIPK3 and Liver Diseases
 Carcinoma Antibodies  >4 publications with RIPK3 and Carcinoma
 Drug-Induced Liver Injury Antibodies  >3 publications with RIPK3 and Drug-Induced Liver Injury
 Weight Loss Antibodies  >2 publications with RIPK3 and Weight Loss
 Liver Neoplasms Antibodies  >2 publications with RIPK3 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with RIPK3 and Cell Transformation, Neoplastic
 Acute Kidney Injury Antibodies  >1 publications with RIPK3 and Acute Kidney Injury
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with RIPK3 and Blood
 Brain Antibodies  >5 publications with RIPK3 and Brain
 Intestine Antibodies  >5 publications with RIPK3 and Intestine
 Liver Antibodies  >5 publications with RIPK3 and Liver
 Kidney Antibodies  >4 publications with RIPK3 and Kidney
 Heart Antibodies  >3 publications with RIPK3 and Heart
 Skin Antibodies  >3 publications with RIPK3 and Skin
 Muscle Antibodies  >3 publications with RIPK3 and Muscle
 Lung Antibodies  >3 publications with RIPK3 and Lung
 Vascular Antibodies  >2 publications with RIPK3 and Vascular
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