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anti-RKIP antibody :: Mouse RKIP Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS852226
Testing Data
Unit / Price
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RKIP, Monoclonal Antibody

★Popular Item★
 Also Known As   

RKIP Antibody

 Product Gene Name   

anti-RKIP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604591
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 Clonality    Monoclonal
 Isotype    IgG2a
 Host    Mouse
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 Specificity    Anti-RKIP recognizes RKIP expression in SW480 whole cell lysate.
 Form/Format    Each vial contains 100 ug IgG in 100 ul of citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.
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 Source Note    Purified mouse monoclonal antibody generated using E Coli expressed recombinant protein RKIP as immunogen.
 Immunogen    Recombinant protein corresponding to full length RKIP.
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 Preparation and Storage    The antibody may be stored at -20 degree C for one year in its original formulation. Additionally, antibody may be stored at 2 degree C to 8 degree C for up to 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles of the diluted antibody.
 Other Notes    Small volumes of anti-RKIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-RKIP antibody    Plant antibody
 Applications Tested/Suitable for anti-RKIP antibody   

ELISA (EIA), Western Blot (WB-Re), Western Blot (WB-Ce)

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 Testing Data of anti-RKIP antibody    anti-RKIP antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for RKIP. It may not necessarily be applicable to this product.
 NCBI GI #    4505621
 NCBI GeneID    5037
 NCBI Accession #    NP_002558.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002567.2 [Other Products]
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 UniProt Secondary Accession #    B2R4S1 [Other Products]
 UniProt Related Accession #    P30086 [Other Products]
 Molecular Weight    21,057 Da
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 NCBI Official Full Name    phosphatidylethanolamine-binding protein 1 preproprotein
 NCBI Official Synonym Full Names    phosphatidylethanolamine binding protein 1
 NCBI Official Symbol    PEBP1 [Similar Products]
 NCBI Official Synonym Symbols   
PBP; HCNP; PEBP; RKIP; HCNPpp; PEBP-1; HEL-210; HEL-S-34
[Similar Products]
 NCBI Protein Information    phosphatidylethanolamine-binding protein 1; neuropolypeptide h3; prostatic binding protein; prostatic-binding protein; raf kinase inhibitor protein; Raf kinase inhibitory protein; epididymis luminal protein 210; epididymis secretory protein Li 34; hippocampal cholinergic neurostimulating peptide
 UniProt Protein Name    Phosphatidylethanolamine-binding protein 1
 UniProt Synonym Protein Names   
HCNPpp; Neuropolypeptide h3; Prostatic-binding protein; Raf kinase inhibitor protein; RKIP
 UniProt Gene Name    PEBP1 [Similar Products]
 UniProt Synonym Gene Names    PBP; PEBP; PEBP-1; RKIP; HCNP [Similar Products]
 UniProt Entry Name    PEBP1_HUMAN
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 NCBI Summary for RKIP    This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]
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 UniProt Comments for RKIP    RKIP: a metastasis suppressor that regulates extracellular matrix remodeling and tumor survival. Binds to and inhibits Raf-1. Phosphorylation by classic and atypical but not novel PKC isoforms dissociates this complex, relieving inhibition of the Raf/MAP kinase signaling cascade. Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. Cleaved into hippocampal cholinergic neurostimulating peptide (HCMP) that appears to be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Expressed in brain. Increased expression in aged senescence-accelerated mice.

Protein type: Protein kinase, regulatory subunit; Lipid-binding

Chromosomal Location of Human Ortholog: 12q24.23

Cellular Component: cytoplasm; nucleus

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; phosphatidylethanolamine binding; protein kinase binding; ATP binding
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 Research Articles on RKIP    1. RKIP expression adds significant value to the molecular subclassification of breast cancer especially for the Luminal A subtype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RKIP antibodyPathways associated with anti-RKIP antibody
 Reference Product  PubMed Publications
 ADRBK1 antibody  >6 publications with RKIP and ADRBK1
 MAPK1 antibody  >4 publications with RKIP and MAPK1
 AURKB antibody  >1 publications with RKIP and AURKB
 RAF1 antibody  >1 publications with RKIP and RAF1
 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with anti-RKIP antibodyOrgans/Tissues associated with anti-RKIP antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >53 publications with RKIP and Carcinoma
 Disease Models, Animal Antibodies  >13 publications with RKIP and Disease Models, Animal
 Liver Diseases Antibodies  >10 publications with RKIP and Liver Diseases
 Liver Neoplasms Antibodies  >9 publications with RKIP and Liver Neoplasms
 Nervous System Diseases Antibodies  >9 publications with RKIP and Nervous System Diseases
 Brain Diseases Antibodies  >9 publications with RKIP and Brain Diseases
 Necrosis Antibodies  >8 publications with RKIP and Necrosis
 Carcinoma, Hepatocellular Antibodies  >7 publications with RKIP and Carcinoma, Hepatocellular
 Lung Neoplasms Antibodies  >6 publications with RKIP and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >6 publications with RKIP and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >43 publications with RKIP and Prostate
 Liver Antibodies  >30 publications with RKIP and Liver
 Blood Antibodies  >29 publications with RKIP and Blood
 Brain Antibodies  >28 publications with RKIP and Brain
 Vascular Antibodies  >16 publications with RKIP and Vascular
 Lymph Node Antibodies  >14 publications with RKIP and Lymph Node
 Lymph Antibodies  >14 publications with RKIP and Lymph
 Lung Antibodies  >11 publications with RKIP and Lung
 Stomach Antibodies  >10 publications with RKIP and Stomach
 Muscle Antibodies  >10 publications with RKIP and Muscle
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