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anti-RNASEH2A antibody :: Mouse anti-Human RNASEH2A Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6010485 anti-RNASEH2A antibody
Unit / Price
0.1 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RNASEH2A, Monoclonal Antibody

 Also Known As   

RNASEH2A (Ribonuclease H2 Subunit A, RNase H2 Subunit A, Ribonuclease HI Subunit A, Ribonuclease HI Large Subunit, RNase HI Large Subunit, RNase H(35), Aicardi-Goutieres Syndrome 4 Protein, AGS4, RNASEHI, RNHIA)

 Product Synonym Names    Anti -RNASEH2A (Ribonuclease H2 Subunit A, RNase H2 Subunit A, Ribonuclease HI Subunit A, Ribonuclease HI Large Subunit, RNase HI Large Subunit, RNase H(35), Aicardi-Goutieres Syndrome 4 Protein, AGS4, RNASEHI, RNHIA)
 Product Gene Name   

anti-RNASEH2A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    MDLSELERDN TGRCRLSSPV PAVCRKEPCV LGVDEAGRGP VLGPMVYAIC YCPLPRLADL EALKVADSKT LLESERERLF AKMEDTDFVG WALDVLSPNL ISTSMLGRVK YNLNSLSHDT ATGLIQYALD QGVNVTQVFV DTVGMPETYQ ARLQQSFPGI EVTVKAKADA LYPVVSAASI CAKVARDQAV KKWQFVEKLQ DLDTDYGSGY PNDPKTKAWL KEHVEPVFGF PQFVRFSWRT AQTILEKEAE DVIWEDSASE NQEGLRKITS YFLNEGSQAR PRSSHRYFLE RGLESATSL
 Chromosome Location    Chromosome: 19; NC_000019.9 (12912863..12924462). Location: 19p13.2
 OMIM    606034
 3D Structure    ModBase 3D Structure for O75792
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    3G5-F5
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human RNASEH2A.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2.
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 Immunogen    Full length recombinant corresponding to aa1-299 from RNASEH2A (AAH11748) with GST tag. MW of the GST tag alone is 26kD.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-RNASEH2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-RNASEH2A antibody    Antibodies; Abs to Disease Markers
 Applications Tested/Suitable for anti-RNASEH2A antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-RNASEH2A antibody    Suitable for use in ELISA and Western Blot.
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NCBI/Uniprot data below describe general gene information for RNASEH2A. It may not necessarily be applicable to this product.
 NCBI GI #    38455391
 NCBI GeneID    10535
 NCBI Accession #    NP_006388.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006397.2 [Other Products]
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 UniProt Primary Accession #    O75792 [Other Products]
 UniProt Secondary Accession #    Q96F11; B2RCY1 [Other Products]
 UniProt Related Accession #    O75792 [Other Products]
 Molecular Weight    33,395 Da [Similar Products]
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 NCBI Official Full Name    ribonuclease H2 subunit A
 NCBI Official Synonym Full Names    ribonuclease H2, subunit A
 NCBI Official Symbol    RNASEH2A [Similar Products]
 NCBI Official Synonym Symbols   
AGS4; JUNB; RNHL; RNHIA; RNASEHI
[Similar Products]
 NCBI Protein Information    ribonuclease H2 subunit A; RNase H(35); RNase H2 subunit A; RNase HI large subunit; ribonuclease HI subunit A; ribonuclease HI large subunit; ribonuclease H2, large subunit; ribonuclease HI, large subunit; aicardi-Goutieres syndrome 4 protein
 UniProt Protein Name    Ribonuclease H2 subunit A
 UniProt Synonym Protein Names   
Aicardi-Goutieres syndrome 4 protein; AGS4; RNase H(35); Ribonuclease HI large subunit; RNase HI large subunit; Ribonuclease HI subunit A
 Protein Family    Ribonuclease
 UniProt Gene Name    RNASEH2A [Similar Products]
 UniProt Synonym Gene Names    RNASEHI; RNHIA; RNase H2 subunit A; AGS4 [Similar Products]
 UniProt Entry Name    RNH2A_HUMAN
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 NCBI Summary for RNASEH2A    The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]
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 UniProt Comments for RNASEH2A    RNASEH2A: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2A are the cause of Aicardi-Goutieres syndrome type 4 (AGS4). A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. Belongs to the RNase HII family. Eukaryotic subfamily.

Protein type: DNA replication; EC 3.1.26.4; Ribonuclease

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: nucleus

Molecular Function: RNA binding; metal ion binding; ribonuclease H activity; ribonuclease activity

Biological Process: mismatch repair; RNA catabolic process; DNA replication

Disease: Aicardi-goutieres Syndrome 4
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 Research Articles on RNASEH2A    1. analysis of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RNASEH2A antibodyPathways associated with anti-RNASEH2A antibody
 Reference Product  PubMed Publications
 RNASEH2C antibody  >4 publications with RNASEH2A and RNASEH2C
 RNASEH2B antibody  >3 publications with RNASEH2A and RNASEH2B
 PCNA antibody  >1 publications with RNASEH2A and PCNA
 Products by Pathway  Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
Diseases associated with anti-RNASEH2A antibodyOrgans/Tissues associated with anti-RNASEH2A antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with RNASEH2A and Neoplasms
 Nervous System Malformations Antibodies  >1 publications with RNASEH2A and Nervous System Malformations
 Neoplasm Metastasis Antibodies  >1 publications with RNASEH2A and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >1 publications with RNASEH2A and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with RNASEH2A and Cell Transformation, Neoplastic
 Aicardi-Goutieres Syndrome 4 Antibodies  >1 publications with RNASEH2A and Aicardi-Goutieres Syndrome 4
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with RNASEH2A and Brain
 Liver Antibodies  >1 publications with RNASEH2A and Liver
 Muscle Antibodies  >1 publications with RNASEH2A and Muscle
 Skin Antibodies  >1 publications with RNASEH2A and Skin
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