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anti-REN antibody :: Mouse Renin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS838098 anti-REN antibody
Unit / Price
0.25 mg  /  $410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Renin, Monoclonal Antibody

★Popular Item★
 Also Known As   

Renin antibody

 Product Synonym Names    Monoclonal Renin; Anti-Renin; FLJ10761; HNFJ2; REN; RENI; Renin; renin precursor renal; angiotensin-forming enzyme; Angiotensinogenase
 Product Gene Name   

anti-REN antibody

[Similar Products]
 Matching Pairs    Capture Antibody: Renin Clone #M83161 (MBS838098)
Detection Antibody: Renin Clone #M83118 (MBS838113)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    179820
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 Clonality    Monoclonal
 Isotype    IgG1 kappa
 Clone Number    M83161
 Host    Mouse
 Species Reactivity    100% for active renin, <4% for Prorenin
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 Specificity    Recognizes human Renin and Prorenin
 Purity/Purification    Renin antibody was purified by urified by Protein A affinity chromatography
 Form/Format    Purified unconjugated liquid in 0.1M BBS, pH 8.0, with no preservative
 Concentration    2.8 mg/ml (lot specific)
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 Immunogen    Human Recombinant renin
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 Preparation and Storage    Store at 4C
 Other Notes    Small volumes of anti-REN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-REN antibody

   Renin is an enzyme that participates in the body's renin-angiotensin system (RAS)-also known as the renin-angiotensin-aldosterone axis-that mediates extracellular volume (i.e., that the blood plasma, lymph and interstitial fluid), and arterial vasocontriction. Thus, it regulates the body's mean arterial blood pressure.
 Product Categories/Family for anti-REN antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-REN antibody   

ELISA (EIA), Radioimmunoassay (RIA), Lateral Flow

 Application Notes for anti-REN antibody    MBS838098 can be used as the capture antibody in a matched pair immunoassay inconjunction with MBS838113 as the detection antibody
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NCBI/Uniprot data below describe general gene information for REN. It may not necessarily be applicable to this product.
 NCBI GI #    4506475
 NCBI GeneID    5972
 NCBI Accession #    NP_000528.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000537.3 [Other Products]
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 UniProt Secondary Accession #    Q6FI38; Q6T5C2 [Other Products]
 UniProt Related Accession #    P00797 [Other Products]
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 NCBI Official Full Name    renin preproprotein
 NCBI Official Synonym Full Names    renin
 NCBI Official Symbol    REN [Similar Products]
 NCBI Official Synonym Symbols   
HNFJ2
[Similar Products]
 NCBI Protein Information    renin
 UniProt Protein Name    Renin
 UniProt Synonym Protein Names   
Angiotensinogenase
 Protein Family    Renin
 UniProt Gene Name    REN [Similar Products]
 UniProt Entry Name    RENI_HUMAN
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 NCBI Summary for REN    Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for REN    REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; EC 3.4.23.15; Secreted; Protease

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space; cytoplasm; plasma membrane; extracellular region

Molecular Function: peptidase activity; insulin-like growth factor receptor binding; aspartic-type endopeptidase activity; receptor binding

Biological Process: response to cAMP; hormone-mediated signaling; male gonad development; renin-angiotensin regulation of aldosterone production; drinking behavior; cell maturation; response to lipopolysaccharide; proteolysis; angiotensin maturation; cellular protein metabolic process; regulation of MAPKKK cascade; regulation of blood pressure; beta-amyloid metabolic process; mesonephros development; kidney development

Disease: Renal Tubular Dysgenesis; Hyperuricemic Nephropathy, Familial Juvenile, 2
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 Research Articles on REN    1. the A allele of rs6682082 of renin is a positive genetic marker for predisposition to essential hypertension and high blood pressure in Korean women.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-REN antibodyPathways associated with anti-REN antibody
 Reference Product  PubMed Publications
 ACE antibody  >152 publications with REN and ACE
 AGT antibody  >63 publications with REN and AGT
 INS antibody  >35 publications with REN and INS
 ACE2 antibody  >22 publications with REN and ACE2
 MME antibody  >7 publications with REN and MME
 ATP6AP2 antibody  >4 publications with REN and ATP6AP2
 CMA1 antibody  >2 publications with REN and CMA1
 KNG1 antibody  >2 publications with REN and KNG1
 CTSG antibody  >1 publications with REN and CTSG
 EDN1 antibody  >1 publications with REN and EDN1
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
Diseases associated with anti-REN antibodyOrgans/Tissues associated with anti-REN antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >4579 publications with REN and Kidney Diseases
 Renal Insufficiency Antibodies  >3077 publications with REN and Renal Insufficiency
 Hypertension Antibodies  >1314 publications with REN and Hypertension
 Heart Diseases Antibodies  >1215 publications with REN and Heart Diseases
 Necrosis Antibodies  >1005 publications with REN and Necrosis
 Acute Kidney Injury Antibodies  >931 publications with REN and Acute Kidney Injury
 Ischemia Antibodies  >685 publications with REN and Ischemia
 Fibrosis Antibodies  >564 publications with REN and Fibrosis
 Myocardial Ischemia Antibodies  >562 publications with REN and Myocardial Ischemia
 Proteinuria Antibodies  >536 publications with REN and Proteinuria
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >5800 publications with REN and Kidney
 Lung Antibodies  >1240 publications with REN and Lung
 Skin Antibodies  >574 publications with REN and Skin
 Intestine Antibodies  >421 publications with REN and Intestine
 Embryonic Tissue Antibodies  >258 publications with REN and Embryonic Tissue
 Pancreas Antibodies  >170 publications with REN and Pancreas
 Bladder Antibodies  >158 publications with REN and Bladder
 Testis Antibodies  >138 publications with REN and Testis
 Ovary Antibodies  >131 publications with REN and Ovary
 Placenta Antibodies  >96 publications with REN and Placenta
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