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| Product Name
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Retinoid X Receptor, g-Isotype (RXRG), Monoclonal Antibody
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| Also Known As
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Anti-Retinoid X Receptor, gamma-Isotype
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Chromosome Location
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Chromosome: 1; NC_000001.11 (165400922..165445355, complement). Location: 1q22-q23
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| OMIM
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180247
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| 3D Structure
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ModBase 3D Structure for P48443
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| Clonality
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Monoclonal
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| Isotype
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IgG1
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| Clone Number
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1373
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| Host
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Mouse
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| Species Reactivity
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Human, rat
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| Specificity
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Specific for the ~48k RXR-gamma isotype.
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| Purity/Purification
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Protein G purified (Prepared from mouse ascites by ammonium sulfate precipitation followed by affinity purification on a protein G column.)
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| Form/Format
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100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
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| Antigen
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Hinge peptide from human retinoid X receptor, gamma-isotype.
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| Immunogen Information
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Synthetic peptide corresponding to amino acid residues from the hinge region conjugated to KLH
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| Immunogen Species
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Human
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| Reactivity Assumed Based on 100% Sequence Homology
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Bovine, mouse, non-human primate
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| Species Reactivity Note
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The antibody has been directly tested for reactivity in Western blots in rat and human tissues. It is anticipated that the antibody will also work with bovine, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
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| Biological Significance
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Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXRalpha, beta and gamma) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
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| Preparation and Storage
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Store at -20 degree C; stable for at least 1 year
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| Other Notes
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Small volumes of anti-RXRG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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Affinity purified mouse monoclonal antibody
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| Applications Tested/Suitable for anti-RXRG antibody
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Western Blot (WB)
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| Application Notes for anti-RXRG antibody
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Quality Control: Western blots performed on each lot.
WB: 1:1000
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| Testing Data of anti-RXRG antibody
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TOP
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| NCBI/Uniprot data below describe general gene information for RXRG. It may not necessarily be applicable to this product. |
| NCBI GI #
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375151581
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| NCBI GeneID
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6258
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| NCBI Accession #
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NP_001243500.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001256571.1
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[Other Products]
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| UniProt Primary Accession #
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P48443
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[Other Products]
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| UniProt Secondary Accession #
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Q6IBU7; A6NIP1
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[Other Products]
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| UniProt Related Accession #
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P48443
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[Other Products]
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| Molecular Weight
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48
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TOP
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| NCBI Official Full Name
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retinoic acid receptor RXR-gamma isoform c
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| NCBI Official Synonym Full Names
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retinoid X receptor, gamma
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| NCBI Official Symbol
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RXRG
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[Similar Products]
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| NCBI Official Synonym Symbols
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RXRC; NR2B3
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[Similar Products]
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| NCBI Protein Information
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retinoic acid receptor RXR-gamma; nuclear receptor subfamily 2 group B member 3
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| UniProt Protein Name
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Retinoic acid receptor RXR-gamma
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| UniProt Synonym Protein Names
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Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma
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| Protein Family
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Retinoic acid receptor
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| UniProt Gene Name
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RXRG
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[Similar Products]
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| UniProt Synonym Gene Names
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NR2B3
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[Similar Products]
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| UniProt Entry Name
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RXRG_HUMAN
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| NCBI Summary for RXRG
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This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
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| UniProt Comments for RXRG
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Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid
By similarity.
Subunit structure: Homodimer
By similarity. Heterodimer with a RAR molecule
By similarity. Binds DNA preferentially as a RAR/RXR heterodimer
By similarity.
Subcellular location: Nucleus
By similarity.
Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain
By similarity.
Sequence similarities: Belongs to the nuclear hormone receptor family. NR2 subfamily.Contains 1 nuclear receptor DNA-binding domain.
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TOP
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Product References and Citations for anti-RXRG antibody
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• Abu J, Batuwangala M, Herbert K, Symonds P (2005) Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. Lancet Oncol 6:712-720.
• Joshi S, Guleria R, Pan J, Dipette D, Singh US (2005) Retinoic acid receptors and tissue-trans-glutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells. Oncogene advance online publication 12 September 2005; doi: 10.1038/sj.onc.1209027.
• Lane MA, Bailey SJ (2005) Role of retinoid signalling in the adult brain. Prog Neurobiol 75:275-293.
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| Research Articles on RXRG
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1. Genetic variation in RXRgamma gene may contribute to the development of HIVLD in combination antiretroviral therapy treated HIV patients.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with anti-RXRG antibody | Pathways associated with anti-RXRG antibody |
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| Diseases associated with anti-RXRG antibody | Organs/Tissues associated with anti-RXRG antibody |
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Antibody 
