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anti-RXRG antibody :: Mouse anti-Human, rat Retinoid X Receptor, g-Isotype Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS500016
Testing Data
Unit / Price
0.1 mL  /  $360 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Retinoid X Receptor, g-Isotype (RXRG), Monoclonal Antibody

 Also Known As   

Anti-Retinoid X Receptor, gamma-Isotype

 Product Gene Name   

anti-RXRG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.11 (165400922..165445355, complement). Location: 1q22-q23
 OMIM    180247
 3D Structure    ModBase 3D Structure for P48443
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1373
 Host    Mouse
 Species Reactivity    Human, rat
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 Specificity    Specific for the ~48k RXR-gamma isotype.
 Purity/Purification    Protein G purified (Prepared from mouse ascites by ammonium sulfate precipitation followed by affinity purification on a protein G column.)
 Form/Format    100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
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 Antigen    Hinge peptide from human retinoid X receptor, gamma-isotype.
 Immunogen Information    Synthetic peptide corresponding to amino acid residues from the hinge region conjugated to KLH
 Immunogen Species    Human
 Reactivity Assumed Based on 100% Sequence Homology    Bovine, mouse, non-human primate
 Species Reactivity Note    The antibody has been directly tested for reactivity in Western blots in rat and human tissues. It is anticipated that the antibody will also work with bovine, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
 Biological Significance    Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXRalpha, beta and gamma) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
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 Preparation and Storage    Store at -20 degree C; stable for at least 1 year
 Other Notes    Small volumes of anti-RXRG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RXRG antibody

   Affinity purified mouse monoclonal antibody
 Applications Tested/Suitable for anti-RXRG antibody   

Western Blot (WB)

 Application Notes for anti-RXRG antibody    Quality Control: Western blots performed on each lot.
WB: 1:1000
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 Testing Data of anti-RXRG antibody    anti-RXRG antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for RXRG. It may not necessarily be applicable to this product.
 NCBI GI #    375151581
 NCBI GeneID    6258
 NCBI Accession #    NP_001243500.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256571.1 [Other Products]
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 UniProt Primary Accession #    P48443 [Other Products]
 UniProt Secondary Accession #    Q6IBU7; A6NIP1 [Other Products]
 UniProt Related Accession #    P48443 [Other Products]
 Molecular Weight    48
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 NCBI Official Full Name    retinoic acid receptor RXR-gamma isoform c
 NCBI Official Synonym Full Names    retinoid X receptor, gamma
 NCBI Official Symbol    RXRG [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    retinoic acid receptor RXR-gamma; nuclear receptor subfamily 2 group B member 3
 UniProt Protein Name    Retinoic acid receptor RXR-gamma
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma
 Protein Family    Retinoic acid receptor
 UniProt Gene Name    RXRG [Similar Products]
 UniProt Synonym Gene Names    NR2B3 [Similar Products]
 UniProt Entry Name    RXRG_HUMAN
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 NCBI Summary for RXRG    This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
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 UniProt Comments for RXRG    Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid

By similarity.

Subunit structure: Homodimer

By similarity. Heterodimer with a RAR molecule

By similarity. Binds DNA preferentially as a RAR/RXR heterodimer

By similarity.

Subcellular location: Nucleus

By similarity.

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain

By similarity.

Sequence similarities: Belongs to the nuclear hormone receptor family. NR2 subfamily.Contains 1 nuclear receptor DNA-binding domain.
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Product References and Citations for anti-RXRG antibody

   • Abu J, Batuwangala M, Herbert K, Symonds P (2005) Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. Lancet Oncol 6:712-720.
• Joshi S, Guleria R, Pan J, Dipette D, Singh US (2005) Retinoic acid receptors and tissue-trans-glutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells. Oncogene advance online publication 12 September 2005; doi: 10.1038/sj.onc.1209027.
• Lane MA, Bailey SJ (2005) Role of retinoid signalling in the adult brain. Prog Neurobiol 75:275-293.
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 Research Articles on RXRG    1. Genetic variation in RXRgamma gene may contribute to the development of HIVLD in combination antiretroviral therapy treated HIV patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RXRG antibodyPathways associated with anti-RXRG antibody
 Reference Product  PubMed Publications
 VDR antibody  >3 publications with RXRG and VDR
 PPARG antibody  >3 publications with RXRG and PPARG
 RARB antibody  >2 publications with RXRG and RARB
 PPARA antibody  >1 publications with RXRG and PPARA
 RARA antibody  >1 publications with RXRG and RARA
 THRB antibody  >1 publications with RXRG and THRB
 THRA antibody  >1 publications with RXRG and THRA
 RARG antibody  >1 publications with RXRG and RARG
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
Diseases associated with anti-RXRG antibodyOrgans/Tissues associated with anti-RXRG antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with RXRG and Inflammation
 Neoplasms Antibodies  >5 publications with RXRG and Neoplasms
 Disease Models, Animal Antibodies  >2 publications with RXRG and Disease Models, Animal
 Lung Neoplasms Antibodies  >1 publications with RXRG and Lung Neoplasms
 Kidney Diseases Antibodies  >1 publications with RXRG and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with RXRG and Liver Neoplasms
 Fatty Liver Antibodies  >1 publications with RXRG and Fatty Liver
 Liver Diseases Antibodies  >1 publications with RXRG and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >7 publications with RXRG and Thyroid
 Muscle Antibodies  >3 publications with RXRG and Muscle
 Brain Antibodies  >3 publications with RXRG and Brain
 Heart Antibodies  >2 publications with RXRG and Heart
 Embryonic Tissue Antibodies  >1 publications with RXRG and Embryonic Tissue
 Uterus Antibodies  >1 publications with RXRG and Uterus
 Skin Antibodies  >1 publications with RXRG and Skin
 Lung Antibodies  >1 publications with RXRG and Lung
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