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anti-RBP4 antibody :: anti-Human Retinol Binding Protein 4 (RBP4) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS312623 anti-RBP4 antibody
Unit / Price
1 mg  /  $830 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Retinol Binding Protein 4 (RBP4), Monoclonal Antibody

 Also Known As   

MAb to Retinol Binding Prot. 4

 Product Synonym Names    Monoclonal Antibody to Human Retinol Binding Protein 4 (RBP4)
 Product Gene Name   

anti-RBP4 antibody

[Similar Products]
 Matching Pairs    Capture Antibody: Retinol Binding Protein 4 (RBP4) Clone #B579M (MBS312624)
Detection Antibody: Retinol Binding Protein 4 (RBP4) Clone #B578M (MBS312623)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (95351593..95360993, complement). Location: 10q23-q24
 OMIM    180250
 3D Structure    ModBase 3D Structure for P02753
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    B578M
 Host    Host: Mouse. Hybridization of Sp 2/0 myeloma cells with spleen cells from BALB/c mice.
Source: Ascites
 Species Reactivity    Human
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 Specificity    Retinol Binding Protein 4 (RBP4)
Human plasma RBP4. Recognizes free RBP4 and RBP4 in complex with transthyretin. Reacts with apo-RBP4 and holo-RBP4.
 Purity/Purification    >90% pure (SDS-PAGE). Protein A chromatography
 Form/Format    Purified, Liquid
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 Immunogen    Human recombinant RBP4
 Affinity Constant    Not determined
 Buffer    PBS, pH 7.4
 Preservative    0.1% Sodium azide
 Notes    Some applications in which these products may be used are covered by patents issued and applicable in certain countries. Because purchase of these products does not include a license to perform any patented application, users of these products may
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
 Warnings    This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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 Preparation and Storage    Store at 2 to 8 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-RBP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-RBP4 antibody    Monoclonal Antibodies to Cytokines and Growth Factors
 Applications Tested/Suitable for anti-RBP4 antibody   

EIA/ELISA, Western Blot, Immunoassay Antibody Pairs

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NCBI/Uniprot data below describe general gene information for RBP4. It may not necessarily be applicable to this product.
 NCBI GI #    62298174
 NCBI GeneID    5950
 NCBI Accession #    P02753 [Other Products]
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 UniProt Primary Accession #    P02753 [Other Products]
 UniProt Secondary Accession #    O43478; O43479; Q5VY24; Q8WWA3; Q9P178; D3DR38 [Other Products]
 UniProt Related Accession #    P02753 [Other Products]
 Molecular Weight    23,010 Da [Similar Products]
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 NCBI Official Full Name    Retinol-binding protein 4
 NCBI Official Synonym Full Names    retinol binding protein 4, plasma
 NCBI Official Symbol    RBP4 [Similar Products]
 NCBI Protein Information    retinol-binding protein 4; RBP; PRBP; OTTHUMP00000020114; OTTHUMP00000020115; OTTHUMP00000020116; plasma retinol-binding protein; retinol-binding protein 4, interstitial
 UniProt Protein Name    Retinol-binding protein 4
 UniProt Synonym Protein Names   
Plasma retinol-binding protein
 Protein Family    Retinol-binding protein
 UniProt Gene Name    RBP4 [Similar Products]
 UniProt Entry Name    RET4_HUMAN
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 NCBI Summary for RBP4    This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq]
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 UniProt Comments for RBP4    Function: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

Subcellular location: Secreted.

Involvement in disease: Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency) [

MIM:180250]. This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium.

Sequence similarities: Belongs to the calycin superfamily. Lipocalin family.

Mass spectrometry: Molecular mass is 21063.46±1.88 Da from positions 17 - 199. Determined by ESI. Ref.10Molecular mass is 20534 Da from positions 19 - 197. Determined by MALDI. Ref.12Molecular mass is 20162 Da from positions 19 - 194. Determined by MALDI. Ref.12

Sequence caution: The sequence AAF69622.1 differs from that shown. Reason: Erroneous initiation.
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 Research Articles on RBP4    1. RBP4 has a robust acute effect of enhancement of NO production via stimulation of part of the PI3K/Akt/eNOS pathway and inhibition of ERK1/2 phosphorylation and insulin-induced ET-1 secretion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RBP4 antibodyPathways associated with anti-RBP4 antibody
 Reference Product  PubMed Publications
 TTR antibody  >19 publications with RBP4 and TTR
 ALB antibody  >1 publications with RBP4 and ALB
 Products by Pathway  Pathway Diagram
 Vitamin A And Carotenoid Metabolism Pathway antibodies  Vitamin A And Carotenoid Metabolism Pathway Diagram
Diseases associated with anti-RBP4 antibodyOrgans/Tissues associated with anti-RBP4 antibody
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >239 publications with RBP4 and Insulin Resistance
 Obesity Antibodies  >151 publications with RBP4 and Obesity
 Diabetes Mellitus, Type 2 Antibodies  >93 publications with RBP4 and Diabetes Mellitus, Type 2
 Inflammation Antibodies  >46 publications with RBP4 and Inflammation
 Female Urogenital Diseases Antibodies  >38 publications with RBP4 and Female Urogenital Diseases
 Cardiovascular Diseases Antibodies  >36 publications with RBP4 and Cardiovascular Diseases
 Liver Diseases Antibodies  >32 publications with RBP4 and Liver Diseases
 Fatty Liver Antibodies  >27 publications with RBP4 and Fatty Liver
 Kidney Diseases Antibodies  >21 publications with RBP4 and Kidney Diseases
 Body Weight Changes Antibodies  >21 publications with RBP4 and Body Weight Changes
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >77 publications with RBP4 and Liver
 Connective Tissue Antibodies  >65 publications with RBP4 and Connective Tissue
 Muscle Antibodies  >34 publications with RBP4 and Muscle
 Kidney Antibodies  >18 publications with RBP4 and Kidney
 Heart Antibodies  >9 publications with RBP4 and Heart
 Brain Antibodies  >7 publications with RBP4 and Brain
 Bone Antibodies  >7 publications with RBP4 and Bone
 Pancreas Antibodies  >6 publications with RBP4 and Pancreas
 Embryonic Tissue Antibodies  >5 publications with RBP4 and Embryonic Tissue
 Lung Antibodies  >3 publications with RBP4 and Lung
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