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anti-RUVBL1 antibody :: Mouse anti-Human RuvB-Like 1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS603855 anti-RUVBL1 antibody
Unit / Price
0.1 mg  /  $565 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RuvB-Like 1 (RUVBL1), Monoclonal Antibody

 Also Known As   

RuvB-Like 1 (RUVBL1, ECP54, NMP238, RVB1, TIP49, TIP49A)

 Product Synonym Names    Anti -RuvB-Like 1 (RUVBL1, ECP54, NMP238, RVB1, TIP49, TIP49A)
 Product Gene Name   

anti-RUVBL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (127799800..127842671, complement). Location: 3q21
 OMIM    603449
 3D Structure    ModBase 3D Structure for Q9Y265
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    8C296
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human RuvB-Like 1.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
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 Immunogen    Partial sequence of recombinant full-length protein to human RuvB-Like 1
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-RUVBL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-RUVBL1 antibody

   Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
 Product Categories/Family for anti-RUVBL1 antibody    Antibodies; Abs to Enzymes
 Applications Tested/Suitable for anti-RUVBL1 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

 Application Notes for anti-RUVBL1 antibody    Suitable for use in Western Blot, Immunocytochemistry and Flow Cytometry.
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NCBI/Uniprot data below describe general gene information for RUVBL1. It may not necessarily be applicable to this product.
 NCBI GI #    4506753
 NCBI GeneID    8607
 NCBI Accession #    NP_003698.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003707.2 [Other Products]
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 UniProt Primary Accession #    Q9Y265 [Other Products]
 UniProt Secondary Accession #    P82276; Q1KMR0; Q53HK5; Q53HL7; Q53Y27; Q9BSX9; B2R5S0 [Other Products]
 UniProt Related Accession #    Q9Y265 [Other Products]
 Molecular Weight    50,228 Da [Similar Products]
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 NCBI Official Full Name    ruvB-like 1
 NCBI Official Synonym Full Names    RuvB-like 1 (E. coli)
 NCBI Official Symbol    RUVBL1 [Similar Products]
 NCBI Official Synonym Symbols   
RVB1; TIH1; ECP54; TIP49; INO80H; NMP238; PONTIN; TIP49A; Pontin52
[Similar Products]
 NCBI Protein Information    ruvB-like 1; ECP-54; NMP 238; pontin 52; TAP54-alpha; OTTHUMP00000216127; OTTHUMP00000216128; INO80 complex subunit H; nuclear matrix protein 238; RuvB (E coli homolog)-like 1; 49 kDa TBP-interacting protein; TIP60-associated protein 54-alpha; 54 kDa erythrocyte cytosolic protein; TATA binding protein interacting protein 49 kDa; 49 kDa TATA box-binding protein-interacting protein
 UniProt Protein Name    RuvB-like 1
 UniProt Synonym Protein Names   
49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP-interacting protein; 54 kDa erythrocyte cytosolic protein; ECP-54; INO80 complex subunit H; Nuclear matrix protein 238; NMP 238; Pontin 52; TIP49a; TIP60-associated protein 54-alpha
 Protein Family    RuvB
 UniProt Gene Name    RUVBL1 [Similar Products]
 UniProt Synonym Gene Names    INO80H; NMP238; TIP49; TIP49A [Similar Products]
 UniProt Entry Name    RUVB1_HUMAN
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 UniProt Comments for RUVBL1    RUVBL1: Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1- CTNNB1 complex. Belongs to the ruvB family. Forms homotypic and heterotypic interactions. Forms a multimeric complex with RUVBL2. Interacts with the transcriptional activation domain of MYC. Component of the RNA polymerase II holoenzyme complex. May also act to bridge the LEF1/TCF1-CTNNB1 complex and TBP. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. RUVBL1 interacts with EP400. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Component of the BAF53 complex, at least composed of ACTL6A/BAF53A, RUVBL1/TIP49, SMARCA2/BRM, and TRRAP/PAF400. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Associates with alpha and gamma tubulins, particularly during metaphase and early anaphase. Interacts with NPAT. Component of the chromatin-remodeling INO80 complex, at least composed of ACTL6A, ACTR5, ACTR8, RVBL1, RVBL2, INO80, INO80B, INO80C, INO80D and INO80E. Interacts with IGHMBP2. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC 3.6.4.12; Helicase

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: nucleoplasm; Golgi apparatus; NuA4 histone acetyltransferase complex; nuclear matrix; intracellular membrane-bound organelle; membrane; cytoplasm; microtubule organizing center; nucleus

Molecular Function: protein binding; DNA helicase activity; ATPase activity; ATP binding

Biological Process: regulation of transcription from RNA polymerase II promoter; nucleosome assembly; mitosis; establishment and/or maintenance of chromatin architecture; DNA replication-independent nucleosome assembly at centromere; transcription, DNA-dependent; cell division; regulation of growth; spermatogenesis; DNA repair; DNA duplex unwinding; DNA recombination
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 Research Articles on RUVBL1    1. S100A9 and NMP238 expression is associated with concurrent chemoradiotherapy sensitivity in cervical carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RUVBL1 antibodyPathways associated with anti-RUVBL1 antibody
 Reference Product  PubMed Publications
 RUVBL2 antibody  >38 publications with RUVBL1 and RUVBL2
 CTNNB1 antibody  >8 publications with RUVBL1 and CTNNB1
 TBP antibody  >3 publications with RUVBL1 and TBP
 CD82 antibody  >1 publications with RUVBL1 and CD82
 Products by Pathway  Pathway Diagram
 C-MYC Pathway antibodies  C-MYC Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway antibodies  Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway Diagram
 Extension Of Telomeres Pathway antibodies  Extension Of Telomeres Pathway Diagram
 Nucleosome Assembly Pathway antibodies  Nucleosome Assembly Pathway Diagram
 Telomere Extension By Telomerase Pathway antibodies  Telomere Extension By Telomerase Pathway Diagram
 Telomere Maintenance Pathway antibodies  Telomere Maintenance Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
Diseases associated with anti-RUVBL1 antibodyOrgans/Tissues associated with anti-RUVBL1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >19 publications with RUVBL1 and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >7 publications with RUVBL1 and Cell Transformation, Neoplastic
 Carcinoma, Hepatocellular Antibodies  >4 publications with RUVBL1 and Carcinoma, Hepatocellular
 Adenocarcinoma Antibodies  >3 publications with RUVBL1 and Adenocarcinoma
 Liver Diseases Antibodies  >3 publications with RUVBL1 and Liver Diseases
 Colorectal Neoplasms Antibodies  >3 publications with RUVBL1 and Colorectal Neoplasms
 Carcinoma, Small Cell Antibodies  >3 publications with RUVBL1 and Carcinoma, Small Cell
 Leukemia Antibodies  >2 publications with RUVBL1 and Leukemia
 Liver Neoplasms Antibodies  >2 publications with RUVBL1 and Liver Neoplasms
 Prostatic Neoplasms Antibodies  >2 publications with RUVBL1 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with RUVBL1 and Liver
 Blood Antibodies  >3 publications with RUVBL1 and Blood
 Prostate Antibodies  >3 publications with RUVBL1 and Prostate
 Thymus Antibodies  >2 publications with RUVBL1 and Thymus
 Vascular Antibodies  >2 publications with RUVBL1 and Vascular
 Testis Antibodies  >2 publications with RUVBL1 and Testis
 Lung Antibodies  >2 publications with RUVBL1 and Lung
 Spleen Antibodies  >1 publications with RUVBL1 and Spleen
 Kidney Antibodies  >1 publications with RUVBL1 and Kidney
 Ovary Antibodies  >1 publications with RUVBL1 and Ovary
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