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anti-SAG antibody :: Mouse S-Arrestin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS605379 anti-SAG antibody
Unit / Price
0.1 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

S-Arrestin (SAG), Monoclonal Antibody

 Also Known As   

S-Arrestin (S Arrestin, S-arrestin, 48kD Protein, DKFZp686I1383, Rod Photoreceptor Arrestin, S Antigen, S-antigen Retina and Pineal Gland, S AG, SAG, S-AG)

 Product Synonym Names    Anti -S-Arrestin (S Arrestin, S-arrestin, 48kD Protein, DKFZp686I1383, Rod Photoreceptor Arrestin, S Antigen, S-antigen Retina and Pineal Gland, S AG, SAG, S-AG)
 Product Gene Name   

anti-SAG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (234216309..234255701). Location: 2q37.1
 OMIM    181031
 3D Structure    ModBase 3D Structure for P10523
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    9G8
 Host    Mouse
 Species Reactivity    Bovine, Human, Porcine
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 Specificity    This antibody is specific for arrestin protein. Species Crossreactivity: This antibody reacts with human, bovine, porcine, and rat (weakly).
 Purity/Purification    Purified
Purified
 Form/Format    Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.
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 Immunogen    Porcine retinal S-antigen (arrestin). [Swiss-Prot# P79260].
 Positive Control    Retina lysate
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 3 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-SAG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SAG antibody

   S-antigen, also identified as arrestin, is a protein involved in the regulation of phototransduction.
 Product Categories/Family for anti-SAG antibody    Antibodies; Abs to Arrestin
 Applications Tested/Suitable for anti-SAG antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-SAG antibody    Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry (Fr).
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NCBI/Uniprot data below describe general gene information for SAG. It may not necessarily be applicable to this product.
 NCBI GI #    116008178
 NCBI GeneID    6295
 NCBI Accession #    NP_000532.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000541.4 [Other Products]
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 UniProt Primary Accession #    P10523 [Other Products]
 UniProt Secondary Accession #    Q53SV3; Q99858 [Other Products]
 UniProt Related Accession #    P10523; Q6MZK5; Q7Z3R3; A0FDN6 [Other Products]
 Molecular Weight    45,120 Da [Similar Products]
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 NCBI Official Full Name    S-arrestin
 NCBI Official Synonym Full Names    S-antigen; retina and pineal gland (arrestin)
 NCBI Official Symbol    SAG [Similar Products]
 NCBI Official Synonym Symbols   
RP47; S-AG; DKFZp686D1084; DKFZp686I1383
[Similar Products]
 NCBI Protein Information    S-arrestin; arrestin 1; 48 kDa protein; OTTHUMP00000203381; rod photoreceptor arrestin; retinal S-antigen (48 KDa protein)
 UniProt Protein Name    S-arrestin
 UniProt Synonym Protein Names   
48 kDa protein; Retinal S-antigen; S-AG; Rod photoreceptor arrestin
 Protein Family    S-arrestin
 UniProt Gene Name    SAG [Similar Products]
 UniProt Entry Name    ARRS_HUMAN
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 NCBI Summary for SAG    Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq]
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 UniProt Comments for SAG    SAG: Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated- phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Retina and pineal gland. Belongs to the arrestin family.

Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: photoreceptor inner segment; photoreceptor outer segment; cytosol

Molecular Function: opsin binding; phosphoprotein binding; protein phosphatase inhibitor activity

Biological Process: rhodopsin mediated signaling; phototransduction, visible light; cell surface receptor linked signal transduction; regulation of rhodopsin mediated signaling; visual perception; negative regulation of catalytic activity

Disease: Oguchi Disease 1; Retinitis Pigmentosa 47
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 Research Articles on SAG    1. maintenance of low levels of the active monomer is the biological role of arrestin-1 self-association
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SAG antibodyPathways associated with anti-SAG antibody
 Reference Product  PubMed Publications
 RHO antibody  >6 publications with SAG and RHO
 ADRA1B antibody  >2 publications with SAG and ADRA1B
 Products by Pathway  Pathway Diagram
 Visual Signal Transduction: Rods Pathway antibodies  Visual Signal Transduction: Rods Pathway Diagram
Diseases associated with anti-SAG antibodyOrgans/Tissues associated with anti-SAG antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >53 publications with SAG and Inflammation
 Skin Diseases Antibodies  >43 publications with SAG and Skin Diseases
 Lung Diseases Antibodies  >24 publications with SAG and Lung Diseases
 Lung Neoplasms Antibodies  >14 publications with SAG and Lung Neoplasms
 Poisoning Antibodies  >13 publications with SAG and Poisoning
 Leishmaniasis, Cutaneous Antibodies  >9 publications with SAG and Leishmaniasis, Cutaneous
 Night Blindness Antibodies  >9 publications with SAG and Night Blindness
 Hypotension Antibodies  >8 publications with SAG and Hypotension
 Asthma Antibodies  >8 publications with SAG and Asthma
 OGUCHI DISEASE 1 Antibodies  >5 publications with SAG and OGUCHI DISEASE 1
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >206 publications with SAG and Brain
 Muscle Antibodies  >116 publications with SAG and Muscle
 Eye Antibodies  >64 publications with SAG and Eye
 Connective Tissue Antibodies  >8 publications with SAG and Connective Tissue
 Ovary Antibodies  >6 publications with SAG and Ovary
 Testis Antibodies  >3 publications with SAG and Testis
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