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anti-SAA1 antibody :: Mouse anti-Human SAA1 / SAA / Serum Amyloid A Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245209
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SAA1 / SAA / Serum Amyloid A, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal (IgG1,k) to Human SAA1 / SAA / Serum Amyloid A

 Product Synonym Names    Anti-SAA1 / SAA / Serum Amyloid A Antibody IHC-plus; SAA1; Serum amyloid A protein; Serum Amyloid A; Serum amyloid A-1 protein; TP53I4; SAA; Serum amyloid A1; PIG4; Human SAA1; SAA; Serum Amyloid A
 Product Gene Name   

anti-SAA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    104750
 3D Structure    ModBase 3D Structure for P02735
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes natural and recombinant human SAA. Does not show any cross-reactivity with other human cytokines or growth factors tested such as IL-1b, IL-8, MCAF, TGF-b and EGF.
 Purity/Purification    Protein G Purified
 Form/Format    PBS, pH 7.2
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Highly purified recombinant human SAA, 12kD.
 Immunogen    SAA1 / SAA / Serum Amyloid A antibody was raised against highly purified recombinant human SAA, 12kD.
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-SAA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SAA1 antibody

   Serum Amyloid A1 (SAA1), a member of the serum amyloid A family of apolipoproteins, is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. It also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of SAA1 are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn s disease. SAA1 may also be a potential biomarker for certain tumors.
 Applications Tested/Suitable for anti-SAA1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-SAA1 antibody    ELISA (0.3 ug/ml), IHC-P (5 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-SAA1 antibody    Anti-SAA1 / Serum Amyloid A antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-SAA1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SAA1. It may not necessarily be applicable to this product.
 NCBI GI #    40316912
 NCBI GeneID    6288
 NCBI Accession #    NP_000322.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000331.4 [Other Products]
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 UniProt Primary Accession #    P02735 [Other Products]
 UniProt Secondary Accession #    P02735; P02736; P02737; Q16730; Q16834; Q16835; Q16879; Q3KRB3; Q6FG67; Q96QN0; Q9UCK9 [Other Products]
 UniProt Related Accession #    P0DJI8 [Other Products]
 Molecular Weight    13,532 Da
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 NCBI Official Full Name    serum amyloid A-1 protein preproprotein
 NCBI Official Synonym Full Names    serum amyloid A1
 NCBI Official Symbol    SAA1 [Similar Products]
 NCBI Official Synonym Symbols   
SAA; PIG4; SAA2; TP53I4
[Similar Products]
 NCBI Protein Information    serum amyloid A-1 protein; serum amyloid A protein; tumor protein p53 inducible protein 4
 UniProt Protein Name    Serum amyloid A-1 protein
 UniProt Synonym Protein Names   
Amyloid fibril protein AA
 Protein Family    Serum amyloid A-1 protein
 UniProt Gene Name    SAA1 [Similar Products]
 UniProt Synonym Gene Names    SAA [Similar Products]
 UniProt Entry Name    SAA1_HUMAN
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 NCBI Summary for SAA1    This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]
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 UniProt Comments for SAA1    SAA1: Major acute phase reactant. Apolipoprotein of the HDL complex. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. Belongs to the SAA family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: extracellular region

Molecular Function: heparin binding; G-protein-coupled receptor binding

Biological Process: receptor-mediated endocytosis; platelet activation; neutrophil chemotaxis; positive regulation of cell adhesion; macrophage chemotaxis; positive regulation of interleukin-1 secretion; elevation of cytosolic calcium ion concentration; regulation of protein secretion; negative regulation of inflammatory response; acute-phase response; innate immune response; lymphocyte chemotaxis; positive regulation of cytokine secretion
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 Research Articles on SAA1    1. we concluded that genetic polymorphisms of SAA1 may be a genetic marker of MI in the Chinese population
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SAA1 antibody
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies  Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies  DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
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