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anti-SCF antibody :: Mouse anti-Human SCF SCF Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS532166 anti-SCF antibody
Unit / Price
0.5 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SCF, Monoclonal Antibody

 Also Known As   

SCF antibody

 Product Synonym Names    Monoclonal SCF; Anti-SCF; Mast Cell Growth Factor; Stem Cell Factor; Steel Factor; MGF; c-Kit Ligand; SCF; Anti SCF
 Product Gene Name   

anti-SCF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    145250
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 Clonality    Monoclonal
 Isotype    IgG1 kappa
 Clone Number    M912288
 Host    Mouse
 Species Reactivity    Human SCF
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 Form/Format    Lyophilized from PBS.
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 Biological Significance    Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on Mouse cells, while Mouse and rat SCF are fully active on human cells.
 Immunogen    SCF antibody was raised in mouse using highly pure recombinant human SCF as the immunogen.
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 Preparation and Storage    Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-SCF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SCF antibody

   Mouse monoclonal SCF antibody
 Product Categories/Family for anti-SCF antibody    Cytokines & Growth Factors
 Applications Tested/Suitable for anti-SCF antibody   

ELISA (EIA), Inhibition, Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for SCF. It may not necessarily be applicable to this product.
 NCBI GI #    1246100
 NCBI GeneID    4254
 NCBI Accession #    AAB35922.1 [Other Products]
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 UniProt Secondary Accession #    Q16487; Q68DZ2; Q7M4N8; Q9UQK7; A0AV09; A8K2Q4; B7ZLM4 [Other Products]
 UniProt Related Accession #    P21583 [Other Products]
 Molecular Weight    18.4 kDa (predicted detection band MW)
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 NCBI Official Full Name    stem cell factor, partial
 NCBI Official Synonym Full Names    KIT ligand
 NCBI Official Symbol    KITLG [Similar Products]
 NCBI Official Synonym Symbols   
SF; MGF; SCF; FPH2; FPHH; KL-1; Kitl; SHEP7
[Similar Products]
 NCBI Protein Information    kit ligand
 UniProt Protein Name    Kit ligand
 UniProt Synonym Protein Names   
Mast cell growth factor; MGF
 Protein Family    SCF-associated factor
 UniProt Gene Name    KITLG [Similar Products]
 UniProt Synonym Gene Names    MGF; SCF; MGF; SCF; sKITLG [Similar Products]
 UniProt Entry Name    SCF_HUMAN
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 NCBI Summary for SCF    This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SCF    SCF: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. Belongs to the SCF family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: extracellular space; cytoskeleton; cytoplasm; integral to membrane; extracellular region; plasma membrane

Molecular Function: protein binding; growth factor activity; cytokine activity; stem cell factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; embryonic hemopoiesis; germ cell programmed cell death; male gonad development; signal transduction; positive regulation of MAP kinase activity; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mast cell apoptosis; positive regulation of melanocyte differentiation; innate immune response; positive regulation of myeloid leukocyte differentiation; positive regulation of Ras protein signal transduction; cell adhesion; neural crest cell migration; positive regulation of DNA replication

Disease: Hyperpigmentation, Familial Progressive, 2; Skin/hair/eye Pigmentation, Variation In, 7
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 Research Articles on SCF    1. Paraffin-embedded, formalin-fixed tissue from 100 consecutive patients with invasive breast cancer was immunohistochemically stained for Ki-67 and Ki-67/KL1. Ki-67 was manually scored in different regions by 2 observers and automated image analysis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SCF antibodyPathways associated with anti-SCF antibody
 Reference Product  PubMed Publications
 KIT antibody  >3832 publications with SCF and KIT
 STAT3 antibody  >973 publications with SCF and STAT3
 JAK2 antibody  >292 publications with SCF and JAK2
 MYB antibody  >205 publications with SCF and MYB
 EPOR antibody  >110 publications with SCF and EPOR
 GRB2 antibody  >86 publications with SCF and GRB2
 GDF9 antibody  >38 publications with SCF and GDF9
 SHC1 antibody  >25 publications with SCF and SHC1
 MATK antibody  >3 publications with SCF and MATK
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
Diseases associated with anti-SCF antibodyOrgans/Tissues associated with anti-SCF antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >3812 publications with SCF and Necrosis
 Bone Marrow Diseases Antibodies  >3289 publications with SCF and Bone Marrow Diseases
 Carcinoma Antibodies  >2633 publications with SCF and Carcinoma
 Inflammation Antibodies  >2222 publications with SCF and Inflammation
 Neoplasms, Germ Cell and Embryonal Antibodies  >1864 publications with SCF and Neoplasms, Germ Cell and Embryonal
 Heart Diseases Antibodies  >1543 publications with SCF and Heart Diseases
 Breast Neoplasms Antibodies  >1442 publications with SCF and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1348 publications with SCF and Cell Transformation, Neoplastic
 Myocardial Ischemia Antibodies  >1138 publications with SCF and Myocardial Ischemia
 Anemia Antibodies  >1115 publications with SCF and Anemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19446 publications with SCF and Blood
 Bone Antibodies  >18021 publications with SCF and Bone
 Vascular Antibodies  >6758 publications with SCF and Vascular
 Brain Antibodies  >6002 publications with SCF and Brain
 Embryonic Tissue Antibodies  >5374 publications with SCF and Embryonic Tissue
 Muscle Antibodies  >4002 publications with SCF and Muscle
 Nerve Antibodies  >3695 publications with SCF and Nerve
 Liver Antibodies  >2807 publications with SCF and Liver
 Connective Tissue Antibodies  >2238 publications with SCF and Connective Tissue
 Lung Antibodies  >2009 publications with SCF and Lung
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