NP_001139328.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
SH3 domain-binding protein 2 isoform b
NCBI Official Synonym Full Names
SH3-domain binding protein 2
NCBI Official Synonym Symbols
3BP2; CRBM; CRPM; 3BP-2; RES4-23 [Similar Products]
NCBI Protein Information
SH3 domain-binding protein 2; Abl-SH3 binding protein 2; TNFAIP3 interacting protein 2
UniProt Protein Name
SH3 domain-binding protein 2
UniProt Synonym Gene Names
UniProt Entry Name
3BP2_HUMAN
NCBI Summary for SH3BP2
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Comments for SH3BP2
SH3BP2: an adaptor protein that binds differentially to the SH3 domains of certain proteins. Links the hemopoietic tyrosine kinase Fes to the cytoplasmic membrane in a phosphorylation dependent manner. Regulates FC-epsilon RI -mediated degranulation in rat basophilic leukemia RBL-2H3 cells. Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas. Defects in 3BP2 are the cause of cherubism, an autosomal dominant inherited syndrome. Two differentially spliced isoforms have been described.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4p16.3
Molecular Function: protein binding; SH3/SH2 adaptor activity; SH3 domain binding
Biological Process: positive regulation of signal transduction; signal transduction
Disease: Cherubism
Research Articles on SH3BP2
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Products associated with anti-SH3BP2 antibody
Pathways associated with anti-SH3BP2 antibody
Diseases associated with anti-SH3BP2 antibody
Organs/Tissues associated with anti-SH3BP2 antibody
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