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anti-SHH antibody :: Mouse anti-Human SHH Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850560
Testing Data
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SHH, Monoclonal Antibody

 Also Known As   

SHH Antibody

 Product Synonym Names    TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5; SHH
 Product Gene Name   

anti-SHH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 611638
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 Clonality    Monoclonal
 Clone Number    8G3
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    Purified recombinant fragment of human SHH expressed in E. Coli.
 Species    Mouse IgG1
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at -20 degree C.
 Other Notes    Small volumes of anti-SHH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SHH antibody

   Background: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities.
 Product Categories/Family for anti-SHH antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-SHH antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-SHH antibody    WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000
Not yet tested in other applications.
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 Testing Data of anti-SHH antibody    Figure 1: Western blot analysis using SHH mAb against SHH-hIgGFc transfected HEK293 cell lysate.
anti-SHH antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for SHH. It may not necessarily be applicable to this product.
 NCBI GI #    4506939
 NCBI GeneID    6469
 NCBI Accession #    NP_000184.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000193.2 [Other Products]
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 UniProt Secondary Accession #    Q75MC9; A4D247 [Other Products]
 UniProt Related Accession #    Q15465 [Other Products]
 Molecular Weight    49.6kDa
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 NCBI Official Full Name    sonic hedgehog protein preproprotein
 NCBI Official Synonym Full Names    sonic hedgehog
 NCBI Official Symbol    SHH [Similar Products]
 NCBI Official Synonym Symbols   
TPT; HHG1; HLP3; HPE3; SMMCI; TPTPS; MCOPCB5
[Similar Products]
 NCBI Protein Information    sonic hedgehog protein; sonic hedgehog homolog
 UniProt Protein Name    Sonic hedgehog protein
 UniProt Synonym Protein Names   
HHG-1Cleaved into the following 2 chains:Sonic hedgehog protein N-product; Sonic hedgehog protein C-product
 Protein Family    Sonic hedgehog protein
 UniProt Gene Name    SHH [Similar Products]
 UniProt Synonym Gene Names    SHH [Similar Products]
 UniProt Entry Name    SHH_HUMAN
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 NCBI Summary for SHH    This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SHH    SHH: Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Interacts with HHATL/GUP1 which negatively regulates HHAT-mediated palmitoylation of the SHH N-terminus. N-product is active as a multimer. Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues. Belongs to the hedgehog family.

Protein type: Cell development/differentiation; Oncoprotein; Motility/polarity/chemotaxis; Cell cycle regulation

Chromosomal Location of Human Ortholog: 7q36

Cellular Component: extracellular matrix; extracellular space; cell surface; endoplasmic reticulum lumen; plasma membrane; extracellular region; nucleus; cytosol; lipid raft

Molecular Function: peptidase activity; laminin-1 binding; morphogen activity; protein binding; glycosaminoglycan binding; zinc ion binding; patched binding; calcium ion binding; glycoprotein binding

Biological Process: prostate gland development; central nervous system development; positive regulation of transcription, DNA-dependent; embryonic skeletal development; telencephalon regionalization; embryonic foregut morphogenesis; male genitalia development; inner ear development; neural crest cell migration; hindbrain development; embryonic limb morphogenesis; positive regulation of neuroblast proliferation; camera-type eye development; myotube differentiation; neuron fate commitment; intermediate filament organization; osteoblast development; positive regulation of skeletal muscle cell proliferation; positive regulation of cell division; regulation of proteolysis; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of apoptosis; embryonic forelimb morphogenesis; axon guidance; granule cell precursor proliferation; ventral midline development; spinal cord dorsal/ventral patterning; palate development; positive regulation of striated muscle cell differentiation; thalamus development; negative regulation of transcription from RNA polymerase II promoter; Bergmann glial cell differentiation; negative regulation of T cell proliferation; pancreas development; positive regulation of cell proliferation; forebrain development; thyroid gland development; heart looping; vasculogenesis; negative regulation of cell migration; positive thymic T cell selection; intein-mediated protein splicing; regulation of odontogenesis; androgen metabolic process; spinal cord motor neuron differentiation; pattern specification process; regulation of cell proliferation; odontogenesis of dentine-containing teeth; negative regulation of cell differentiation; embryonic development; stem cell development; positive regulation of protein import into nucleus; dorsal/ventral pattern formation; ureteric bud branching; hindgut morphogenesis; negative regulation of alpha-beta T cell differentiation; lung development; heart development; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; T cell differentiation in the thymus; lymphoid progenitor cell differentiation; Wnt receptor signaling pathway through beta-catenin; proteolysis; embryonic pattern specification; positive regulation of T cell differentiation in the thymus; cell-cell signaling; embryonic digestive tract morphogenesis; midbrain development; ectoderm development; positive regulation of smoothened signaling pathway; positive regulation of oligodendrocyte differentiation; oligodendrocyte development; activation of hh target transcription factor; striated muscle development; endocytosis; positive regulation of skeletal muscle development; negative thymic T cell selection; patterning of blood vessels; branching morphogenesis of a tube; polarity specification of anterior/posterior axis; metanephros development; cell fate specification; embryonic hindlimb morphogenesis; positive regulation of Wnt receptor signaling pathway; dorsoventral neural tube patterning; organ formation; smoothened signaling pathway; hair follicle morphogenesis; thymus development; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; positive regulation of immature T cell proliferation in the thymus; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; formation of anatomical boundary; myoblast differentiation; limb bud formation; establishment of cell polarity; neuroblast proliferation; blood coagulation; cell development; positive regulation of alpha-beta T cell differentiation

Disease: Solitary Median Maxillary Central Incisor; Schizencephaly; Microphthalmia, Isolated, With Coloboma 5; Holoprosencephaly 3
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 Research Articles on SHH    1. Expression of Shh was correlated with the speed of gastric ulcer healing, promoting the regeneration of gastric mucosa
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SHH antibodyPathways associated with anti-SHH antibody
 Reference Product  PubMed Publications
 GLI1 antibody  >541 publications with SHH and GLI1
 GLI3 antibody  >300 publications with SHH and GLI3
 GLI2 antibody  >293 publications with SHH and GLI2
 BMP4 antibody  >244 publications with SHH and BMP4
 PTCH1 antibody  >204 publications with SHH and PTCH1
 HHIP antibody  >43 publications with SHH and HHIP
 GAS1 antibody  >27 publications with SHH and GAS1
 PTCH2 antibody  >24 publications with SHH and PTCH2
 GPC3 antibody  >7 publications with SHH and GPC3
 LRP2 antibody  >4 publications with SHH and LRP2
 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Glypican 3 Network Pathway antibodies  Glypican 3 Network Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Ligand Biogenesis Pathway antibodies  Hedgehog Ligand Biogenesis Pathway Diagram
Diseases associated with anti-SHH antibodyOrgans/Tissues associated with anti-SHH antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >564 publications with SHH and Nervous System Diseases
 Brain Diseases Antibodies  >313 publications with SHH and Brain Diseases
 Abnormalities, Multiple Antibodies  >302 publications with SHH and Abnormalities, Multiple
 Craniofacial Abnormalities Antibodies  >229 publications with SHH and Craniofacial Abnormalities
 Disease Models, Animal Antibodies  >213 publications with SHH and Disease Models, Animal
 Holoprosencephaly Antibodies  >197 publications with SHH and Holoprosencephaly
 Adenocarcinoma Antibodies  >129 publications with SHH and Adenocarcinoma
 Skin Diseases Antibodies  >115 publications with SHH and Skin Diseases
 Neural Tube Defects Antibodies  >105 publications with SHH and Neural Tube Defects
 Holoprosencephaly 3 Antibodies  >80 publications with SHH and Holoprosencephaly 3
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1034 publications with SHH and Brain
 Lung Antibodies  >186 publications with SHH and Lung
 Liver Antibodies  >99 publications with SHH and Liver
 Intestine Antibodies  >80 publications with SHH and Intestine
 Uncharacterized Tissue Antibodies  >2 publications with SHH and Uncharacterized Tissue
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