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anti-SHIP antibody :: Rabbit anti-Human SHIP Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8533733 anti-SHIP antibody
Unit / Price
0.1 mL  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SHIP, Monoclonal Antibody

 Also Known As   

SHIP

 Product Synonym Names    SIP-145; SH2 domain-containing inositol phosphatase 1; SHIP-1; hp51CN; INPP5D; SHIP; SHIP1; Phosphatidylinositol 3; 4; 5-trisphosphate 5-phosphatase 1; Inositol polyphosphate-5-phosphatase of 145 kDa; SH2 domain-containing inositol 5'-phosphatase 1; p150Ship
 Product Gene Name   

anti-SHIP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601582
 3D Structure    ModBase 3D Structure for Q92835
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 Clonality    Monoclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    ProA affinity purified
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 Immunogen    Recombinant Protein
 Storage Buffer    1*TBS (pH7.4), 1% BSA, 40% Glycerol.
 Preservative    0.05% Sodium Azide.
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 Preparation and Storage    Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-SHIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SHIP antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)

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NCBI/Uniprot data below describe general gene information for SHIP. It may not necessarily be applicable to this product.
 NCBI GI #    64085167
 NCBI GeneID    3635
 NCBI Accession #    NP_001017915.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001017915.2 [Other Products]
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 UniProt Primary Accession #    Q92835 [Other Products]
 UniProt Secondary Accession #    O00145; Q13544; Q13545; Q6P5A4; Q92656; Q9UE80 [Other Products]
 UniProt Related Accession #    Q92835 [Other Products]
 Molecular Weight    109,294 Da
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 NCBI Official Full Name    phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform a
 NCBI Official Synonym Full Names    inositol polyphosphate-5-phosphatase D
 NCBI Official Symbol    INPP5D [Similar Products]
 NCBI Official Synonym Symbols   
SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship
[Similar Products]
 NCBI Protein Information    phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
 UniProt Protein Name    Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
 UniProt Synonym Protein Names   
Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1; p150Ship; hp51CN
 UniProt Gene Name    INPP5D [Similar Products]
 UniProt Synonym Gene Names    SHIP; SHIP1; SIP-145; SH2 domain-containing inositol phosphatase 1; SHIP-1; hp51CN [Similar Products]
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 NCBI Summary for SHIP    This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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 UniProt Comments for SHIP    Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.
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 Research Articles on SHIP    1. Overall evidence did not indicate that inositol polyphosphate-5-phosphatase (INPP5D) rs35349669 single nucleotide polymorphism play a role in the genetic predisposition to late-onset Alzheimer's disease (LOAD) in Chinese population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SHIP antibodyPathways associated with anti-SHIP antibody
 Reference Product  PubMed Publications
 PLCG1 antibody  >1 publications with SHIP and PLCG1
 GRB2 antibody  >1 publications with SHIP and GRB2
 Products by Pathway  Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
Diseases associated with anti-SHIP antibodyOrgans/Tissues associated with anti-SHIP antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with SHIP and Neoplasms
 Fibrosis Antibodies  >1 publications with SHIP and Fibrosis
 Carcinoma Antibodies  >1 publications with SHIP and Carcinoma
 Liver Cirrhosis Antibodies  >1 publications with SHIP and Liver Cirrhosis
 Liver Diseases Antibodies  >1 publications with SHIP and Liver Diseases
 Death Antibodies  >1 publications with SHIP and Death
 Inflammation Antibodies  >1 publications with SHIP and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with SHIP and Blood
 Brain Antibodies  >1 publications with SHIP and Brain
 Lymph Antibodies  >1 publications with SHIP and Lymph
 Spleen Antibodies  >1 publications with SHIP and Spleen
 Lymph Node Antibodies  >1 publications with SHIP and Lymph Node
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