NP_001164627.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,486 Da
NCBI Official Full Name
sialic acid-binding Ig-like lectin 10 isoform 2
NCBI Official Synonym Full Names
sialic acid binding Ig-like lectin 10
NCBI Protein Information
sialic acid-binding Ig-like lectin 10; sialic acid binding Ig-like lectin 10 Ig-like lectin 7; siglec-like gene 2; siglec-like protein 2
UniProt Protein Name
Sialic acid-binding Ig-like lectin 10
UniProt Synonym Protein Names
Siglec-like protein 2
UniProt Synonym Gene Names
UniProt Entry Name
SIG10_HUMAN
NCBI Summary for SIGLEC-10
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
UniProt Comments for SIGLEC-10
Siglec-10: a cell surface protein belonging to the immunoglobulin superfamily and the SIGLEC (sialic acid binding Ig-like lectin) family. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Five alternatively spliced isoforms have been described.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: extracellular region; plasma membrane; integral to membrane
Molecular Function: carbohydrate binding
Biological Process: cell adhesion
Research Articles on SIGLEC-10
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Products associated with anti-SIGLEC-10 antibody
Diseases associated with anti-SIGLEC-10 antibody
Organs/Tissues associated with anti-SIGLEC-10 antibody
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