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anti-SIRT5 antibody :: Mouse anti-Human SIRT5 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS832681
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SIRT5, Monoclonal Antibody

 Also Known As   

SIRT5 antibody

 Product Synonym Names    Monoclonal SIRT5; Anti-SIRT5; Sirtuin; Silent Mating Type Information Regulation 2 homolog 5; SIR2L5; SIRT5; SIRT 5; SIRT-5
 Product Gene Name   

anti-SIRT5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604483
 3D Structure    ModBase 3D Structure for Q9NXA8
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    2 E10
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    SIRT5 antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    SIRT5 is included in class III of the sirtuin family which ischaracterized by a sirtuin core domain. Human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing. and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
 Immunogen    SIRT5 antibody was raised in mouse using a full length recombinant protein of human SIRT5 (NP_036373) produced in HEK293T cells, as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-SIRT5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SIRT5 antibody

   Mouse monoclonal SIRT5 antibody
 Product Categories/Family for anti-SIRT5 antibody    Cell Biology
 Applications Tested/Suitable for anti-SIRT5 antibody   

Flow Cytometry (FC/FACS), Western Blot (WB)

 Application Notes for anti-SIRT5 antibody    FC: 1:100
WB: 1:2000
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 Flow Cytometry (FC/FACS) of anti-SIRT5 antibody    Flow Cytometric analysis of HEK293T cells transfected with either recombinant SIRT5 protein (red) or empty vector (blue) stained using SIRT5 antibody
anti-SIRT5 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Western Blot (WB) of anti-SIRT5 antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant SIRT5 protein (Right) or empty vector (Left) detected with SIRT5 antibody
anti-SIRT5 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SIRT5. It may not necessarily be applicable to this product.
 NCBI GI #    6912664
 NCBI GeneID    23408
 NCBI Accession #    NP_036373 [Other Products]
 NCBI GenBank Nucleotide #    NM_012241.4 [Other Products]
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 UniProt Primary Accession #    Q9NXA8 [Other Products]
 UniProt Secondary Accession #    Q5T294; Q5T295; Q9Y6E6; B4DFM4; B4DYJ5; F5H5Z9 [Other Products]
 UniProt Related Accession #    Q9NXA8 [Other Products]
 Molecular Weight    21,689 Da
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 NCBI Official Full Name    NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1
 NCBI Official Synonym Full Names    sirtuin 5
 NCBI Official Symbol    SIRT5 [Similar Products]
 NCBI Official Synonym Symbols   
SIR2L5
[Similar Products]
 NCBI Protein Information    NAD-dependent protein deacylase sirtuin-5, mitochondrial
 UniProt Protein Name    NAD-dependent protein deacylase sirtuin-5, mitochondrial
 UniProt Synonym Protein Names   
Regulatory protein SIR2 homolog 5
 Protein Family    NAD-dependent protein deacylase sirtuin
 UniProt Gene Name    SIRT5 [Similar Products]
 UniProt Entry Name    SIR5_HUMAN
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 NCBI Summary for SIRT5    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]
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 UniProt Comments for SIRT5    SIRT5: NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD- dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. Belongs to the sirtuin family. Class III subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Deacetylase; EC 3.5.1.-

Chromosomal Location of Human Ortholog: 6p23

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial intermembrane space; cytosol; nucleus

Molecular Function: zinc ion binding; NAD+ ADP-ribosyltransferase activity

Biological Process: protein amino acid ADP-ribosylation; protein amino acid deacetylation; chromatin silencing
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 Research Articles on SIRT5    1. This study demonstrated that SIRT15 downregulation in the liver of non-alcoholic fatty liver disease patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SIRT5 antibodyPathways associated with anti-SIRT5 antibody
 Reference Product  PubMed Publications
 SIRT3 antibody  >62 publications with SIRT5 and SIRT3
 HDAC10 antibody  >2 publications with SIRT5 and HDAC10
 HDAC6 antibody  >2 publications with SIRT5 and HDAC6
 HDAC9 antibody  >2 publications with SIRT5 and HDAC9
 HDAC7 antibody  >1 publications with SIRT5 and HDAC7
 HDAC3 antibody  >1 publications with SIRT5 and HDAC3
 Products by Pathway  Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram
Diseases associated with anti-SIRT5 antibodyOrgans/Tissues associated with anti-SIRT5 antibody
 Disease Name  Pubmed Publications
 Death Antibodies  >10 publications with SIRT5 and Death
 Nervous System Diseases Antibodies  >5 publications with SIRT5 and Nervous System Diseases
 Fatty Liver Antibodies  >4 publications with SIRT5 and Fatty Liver
 Liver Diseases Antibodies  >4 publications with SIRT5 and Liver Diseases
 Inflammation Antibodies  >3 publications with SIRT5 and Inflammation
 Adenocarcinoma Antibodies  >3 publications with SIRT5 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >3 publications with SIRT5 and Cardiovascular Diseases
 Lung Diseases Antibodies  >2 publications with SIRT5 and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with SIRT5 and Carcinoma, Hepatocellular
 Hyperglycemia Antibodies  >2 publications with SIRT5 and Hyperglycemia
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >18 publications with SIRT5 and Liver
 Brain Antibodies  >9 publications with SIRT5 and Brain
 Heart Antibodies  >6 publications with SIRT5 and Heart
 Blood Antibodies  >5 publications with SIRT5 and Blood
 Lung Antibodies  >4 publications with SIRT5 and Lung
 Connective Tissue Antibodies  >3 publications with SIRT5 and Connective Tissue
 Adipose Tissue Antibodies  >3 publications with SIRT5 and Adipose Tissue
 Pancreas Antibodies  >3 publications with SIRT5 and Pancreas
 Intestine Antibodies  >1 publications with SIRT5 and Intestine
 Eye Antibodies  >1 publications with SIRT5 and Eye
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