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anti-SIRT6 antibody :: Mouse SIRT6 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS475406
Unit / Price
0.1 mL  /  $335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SIRT6, Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-SIRT6 Mouse mAb

 Product Synonym Names    2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent protein deacetylase sirtuin-6; Regulatory protein SIR2 homolog 6; Regulatory protein SIR2 homolog; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2
 Product Gene Name   

anti-SIRT6 antibody

[Similar Products]
 Product Synonym Gene Name    SIR2L6. [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF233396 mRNA
 3D Structure    ModBase 3D Structure for Q8N6T7
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    6C9-D10-D3
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat, Monkey
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 Purity/Purification    Affinity Purified
 Form/Format    PBS (pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
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 Immunogen    Purified recombinant human SIRT6 protein expressed in E Coli.
 Sensitivity    This antibody detects endogenous levels of SIRT6 and does not cross-react with related proteins.
 Sequence Similarities    Belongs to the sirtuin family. Class IV subfamily.Contains 1 deacetylase sirtuin-type domain.
 Subcellular Location    Nucleus
 Antibody Diluents    5% w/v nonfat dry milk, 1 x PBS, 0.1%Tween-20
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 Preparation and Storage    Aliquot and store at -20C. Avoid repeated freeze/thaw cycles
 Other Notes    Small volumes of anti-SIRT6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SIRT6 antibody

   Entrez Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been det
 Product Categories/Family for anti-SIRT6 antibody    Epigenetics and Nuclear Signaling; Nuclear Signaling Pathways; NFkB pathway; Epigenetics and Nuclear Signaling; Chromatin Modifying Enzymes; Acetylation; HDACs; Class III / Sir2 class
 Applications Tested/Suitable for anti-SIRT6 antibody   

Western Blot (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

 Application Notes for anti-SIRT6 antibody    WB: 1:500
ICC: 1:100
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 Western Blot (WB) of anti-SIRT6 antibody    Western blot analysis of extracts from Jurkat, MCF7, HCT116, K562, COS7, C2C12, 3T3 and Hela cell lysates using SIRT6 mouse mAb (1:500 diluted).Predicted band size:42, 36KDa.Observed band size:42, 36KDa.
anti-SIRT6 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-SIRT6 antibody    Immunofluorescent analysis of Hela cells fixed fixed by 4% paraformaldehyde and using SIRT6 mouse mAb (dilution 1:100).
anti-SIRT6 antibody Immunofluorescence (IF) image
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 Immunoprecipitation (IP) of anti-SIRT6 antibody    Immunoprecipitation analysis of Hela cell lysates using SIRT6 mouse mAb.
anti-SIRT6 antibody Immunoprecipitation (IP) (IP) image
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NCBI/Uniprot data below describe general gene information for SIRT6. It may not necessarily be applicable to this product.
 NCBI GI #    300797597
 NCBI GeneID    51548
 NCBI Accession #    NP_001180214.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_016539 [Other Products]
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 UniProt Primary Accession #    Q8N6T7 [Other Products]
 UniProt Secondary Accession #    O75291; Q6IAF5; Q6PK99; Q8NCD2; Q9BSI5; Q9BWP3; Q9NRC7; Q9UQD1; B2RCD0 [Other Products]
 UniProt Related Accession #    Q8N6T7 [Other Products]
 Molecular Weight    42
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 NCBI Official Full Name    NAD-dependent protein deacetylase sirtuin-6 isoform 2
 NCBI Official Synonym Full Names    sirtuin 6
 NCBI Official Symbol    SIRT6 [Similar Products]
 NCBI Official Synonym Symbols   
SIR2L6
[Similar Products]
 NCBI Protein Information    NAD-dependent protein deacetylase sirtuin-6
 UniProt Protein Name    NAD-dependent protein deacetylase sirtuin-6
 UniProt Synonym Protein Names   
Regulatory protein SIR2 homolog 6; SIR2-like protein 6
 Protein Family    NAD-dependent protein deacetylase
 UniProt Gene Name    SIRT6 [Similar Products]
 UniProt Synonym Gene Names    SIR2L6 [Similar Products]
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 NCBI Summary for SIRT6    This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
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 UniProt Comments for SIRT6    SIRT6: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8. Belongs to the sirtuin family. Class IV subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nuclear telomeric heterochromatin; nucleolus; nucleoplasm; nucleus

Molecular Function: NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; zinc ion binding

Biological Process: positive regulation of chromatin silencing at telomere; positive regulation of telomere maintenance; protein amino acid ADP-ribosylation
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 Research Articles on SIRT6    1. this study shoes that through the antiglycolytic activity of SIRT6, the autophagy is suppressed, which is beneficial to nasal polyp formation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SIRT6 antibodyDiseases associated with anti-SIRT6 antibody
 Products by Pathway  Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 SREBF And MiR33 In Cholesterol And Lipid Homeostasis Pathway antibodies  SREBF And MiR33 In Cholesterol And Lipid Homeostasis Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >32 publications with SIRT6 and Inflammation
 Liver Diseases Antibodies  >16 publications with SIRT6 and Liver Diseases
 Necrosis Antibodies  >12 publications with SIRT6 and Necrosis
 Hypertrophy Antibodies  >8 publications with SIRT6 and Hypertrophy
 Fatty Liver Antibodies  >7 publications with SIRT6 and Fatty Liver
 Liver Neoplasms Antibodies  >6 publications with SIRT6 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >6 publications with SIRT6 and Carcinoma, Hepatocellular
 Cardiomegaly Antibodies  >6 publications with SIRT6 and Cardiomegaly
 Atherosclerosis Antibodies  >4 publications with SIRT6 and Atherosclerosis
 Breast Neoplasms Antibodies  >4 publications with SIRT6 and Breast Neoplasms
Organs/Tissues associated with anti-SIRT6 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >28 publications with SIRT6 and Liver
 Blood Antibodies  >21 publications with SIRT6 and Blood
 Muscle Antibodies  >19 publications with SIRT6 and Muscle
 Brain Antibodies  >18 publications with SIRT6 and Brain
 Heart Antibodies  >17 publications with SIRT6 and Heart
 Lung Antibodies  >8 publications with SIRT6 and Lung
 Skin Antibodies  >6 publications with SIRT6 and Skin
 Kidney Antibodies  >5 publications with SIRT6 and Kidney
 Bone Antibodies  >5 publications with SIRT6 and Bone
 Ovary Antibodies  >4 publications with SIRT6 and Ovary
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