NM_000578
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
SLC11A1 protein
NCBI Official Synonym Full Names
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
NCBI Protein Information
natural resistance-associated macrophage protein 1; NRAMP 1; solute carrier family 11 member 1; solute carrier family 11 (sodium/phosphate symporters), member 1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
UniProt Protein Name
Natural resistance-associated macrophage protein 1
UniProt Synonym Protein Names
Solute carrier family 11 member 1
UniProt Synonym Gene Names
UniProt Entry Name
NRAM1_HUMAN
NCBI Summary for SLC11A1
This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for SLC11A1
SLC11A1: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. Belongs to the NRAMP family.
Protein type: Cell surface; Membrane protein, multi-pass; Vesicle; Transporter; Membrane protein, integral; Transporter, SLC family
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: phagocytic vesicle membrane; integral to plasma membrane; late endosome membrane; lysosome; late endosome; plasma membrane
Molecular Function: transition metal ion transmembrane transporter activity; protein homodimerization activity; manganese ion transmembrane transporter activity; metal ion:hydrogen antiporter activity
Biological Process: respiratory burst; wound healing; positive regulation of T-helper 1 type immune response; cellular iron ion homeostasis; positive regulation of dendritic cell antigen processing and presentation; manganese ion transport; response to lipopolysaccharide; defense response to Gram-negative bacterium; antigen processing and presentation of peptide antigen; vacuolar acidification; nitrite transport; T cell proliferation during immune response; T cell cytokine production; positive regulation of phagocytosis; interleukin-3 production; inflammatory response; transmembrane transport; positive regulation of cytokine production; interaction with host; mRNA stabilization; L-arginine import; defense response to protozoan; interleukin-2 production; iron ion transport; phagocytosis; iron ion homeostasis; MHC class II biosynthetic process; positive regulation of interferon-gamma production; cellular cadmium ion homeostasis; macrophage activation; response to bacterium; protein import into nucleus, translocation; negative regulation of cytokine production; defense response to bacterium; activation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter
Disease: Buruli Ulcer, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To
Research Articles on SLC11A1
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Products associated with anti-SLC11A1 antibody
Pathways associated with anti-SLC11A1 antibody
Diseases associated with anti-SLC11A1 antibody
Disease Name |
Pubmed Publications |
Tuberculosis Antibodies |
>44 publications with SLC11A1 and Tuberculosis |
Inflammation Antibodies |
>24 publications with SLC11A1 and Inflammation |
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO Antibodies |
>19 publications with SLC11A1 and MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO |
Necrosis Antibodies |
>15 publications with SLC11A1 and Necrosis |
Disease Models, Animal Antibodies |
>12 publications with SLC11A1 and Disease Models, Animal |
Diabetes Mellitus, Type 1 Antibodies |
>10 publications with SLC11A1 and Diabetes Mellitus, Type 1 |
Inflammatory Bowel Diseases Antibodies |
>8 publications with SLC11A1 and Inflammatory Bowel Diseases |
HIV Infections Antibodies |
>7 publications with SLC11A1 and HIV Infections |
Arthritis, Rheumatoid Antibodies |
>7 publications with SLC11A1 and Arthritis, Rheumatoid |
Leishmaniasis, Visceral Antibodies |
>6 publications with SLC11A1 and Leishmaniasis, Visceral |
Organs/Tissues associated with anti-SLC11A1 antibody
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