AAH30593.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,980 Da
NCBI Official Full Name
SLC18A2 protein
NCBI Official Synonym Full Names
solute carrier family 18 (vesicular monoamine transporter), member 2
NCBI Protein Information
synaptic vesicular amine transporter
UniProt Protein Name
Synaptic vesicular amine transporter
UniProt Synonym Protein Names
Monoamine transporter; Solute carrier family 18 member 2; Vesicular amine transporter 2; VAT2
UniProt Synonym Gene Names
UniProt Entry Name
VMAT2_HUMAN
NCBI Summary for SLC18A2
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]
UniProt Comments for SLC18A2
SLC18A2: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. Belongs to the major facilitator superfamily. Vesicular transporter family.
Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 10q25
Cellular Component: synaptic vesicle; cell soma; synaptic vesicle membrane; membrane; integral to plasma membrane; plasma membrane; terminal button
Molecular Function: serotonin transmembrane transporter activity; enzyme binding; amine transmembrane transporter activity; heat shock protein binding; monoamine transmembrane transporter activity; drug binding
Biological Process: dopamine transport; amine transport; death; neurotransmitter secretion; response to amphetamine; monoamine transport; locomotory behavior; response to herbicide; sequestering of neurotransmitter; glucose homeostasis; endocytic recycling; response to cocaine; post-embryonic development; response to starvation; synaptic transmission; insulin secretion; response to zinc ion; serotonin transport; transmembrane transport; negative regulation of neurotransmitter transport; response to corticosterone stimulus; aging
Research Articles on SLC18A2
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Products associated with anti-SLC18A2 antibody
Pathways associated with anti-SLC18A2 antibody
Diseases associated with anti-SLC18A2 antibody
Organs/Tissues associated with anti-SLC18A2 antibody
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